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Western University

Series

2010

Genetics

Articles 1 - 2 of 2

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The Role Of Brain-Derived Neurotrophic Factor Genotype, Parental Depression, And Relationship Discord In Predicting Early-Emerging Negative Emotionality, Elizabeth P. Hayden, Daniel N. Klein, Lea R. Dougherty, Thomas M. Olino, Margaret W. Dyson, C. Durbin, Haroon I. Sheikh, Shiva M. Singh Nov 2010

The Role Of Brain-Derived Neurotrophic Factor Genotype, Parental Depression, And Relationship Discord In Predicting Early-Emerging Negative Emotionality, Elizabeth P. Hayden, Daniel N. Klein, Lea R. Dougherty, Thomas M. Olino, Margaret W. Dyson, C. Durbin, Haroon I. Sheikh, Shiva M. Singh

Paediatrics Publications

The brain-derived neurotrophic factor (BDNF) gene is a plausible candidate for early-emerging negative emotionality (NE), and evidence suggests that the effects of this gene may be especially salient in the context of familial risk for child maladjustment. We therefore examined whether the single-nucleotide polymorphism producing a valine-to-methionine substitution at codon 66 (val66met) of the BDNF gene was associated with childhood NE, in the context of parental depression and relationship discord. A sample of 413 three-year-old children was assessed for NE using standardized laboratory measures. The children's parents completed clinical interviews as well as a measure of marital satisfaction. Children with …


Morally Justifying Oncofertility Science, Carolyn Mcleod Jan 2010

Morally Justifying Oncofertility Science, Carolyn Mcleod

Philosophy Publications

Is research aimed at preserving the fertility of cancer patients morally justified? A satisfying answer to this question is missing from the literature on oncofertility. Rather than provide an answer, which is impossible to do in a short space, this paper explains what it would take to provide such justification.