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Lockdown, Bottoms Up? Changes In Adolescent Substance Use Across The Covid-19 Pandemic, Tara M. Dumas, Wendy E. Ellis, Stephen Van Hedger, Dana M. Litt, Madeleine Macdonald
Lockdown, Bottoms Up? Changes In Adolescent Substance Use Across The Covid-19 Pandemic, Tara M. Dumas, Wendy E. Ellis, Stephen Van Hedger, Dana M. Litt, Madeleine Macdonald
Neuroscience Institute Publications
The COVID-19 pandemic notably altered adolescent substance use during the initial stage (Spring 2020) of the pandemic. The purpose of this longitudinal study is to examine trajectories of adolescent substance use across the pandemic and subsequent periods of stay-at-home orders and re-opening efforts. We further examined differences as a function of current high school student versus graduate status. Adolescents (n = 1068, 14–18 years, Mage = 16.95 years and 76.7% female at T1) completed 4 different self-report surveys, starting during the first stay-at-home order and ending approximately 14 months later. Negative binomial hurdle models predicted: (1) the likelihood of no …
The Hospitalization Rate Of Cerebral Venous Sinus Thrombosis Before And During Covid-19 Pandemic Era: A Single-Center Retrospective Cohort Study, Maryam Vasaghi Gharamaleki, Maryam Habibagahi, Etrat Hooshmandi, Reza Tabrizi, Shahram Arsang-Jang, Zohreh Barzegar, Nima Fadakar, Vahid Reza Ostovan, Abbas Rahimi-Jaberi, Nahid Ashjazadeh, Peyman Petramfar, Maryam Poursadeghfard, Sadegh Izadi, Masoumeh Nazeri, Hanieh Bazrafshan, Zahra Bahrami, Sedigheh Karimlu, Seyedeh Shaghayegh Zafarmand, Mahnaz Bayat, Mohammad Saied Salehi, Maryam Owjfard, Saeideh Karimi-Haghighi, Anahid Safari, Banafsheh Shakibajahromi, Beng Lim Alvin Chew, Bradford B.G. Worral, Jonathan M. Coutinho, Carlos Garcia-Esperon, Neil Spratt, M Reza Azarpazhooh
The Hospitalization Rate Of Cerebral Venous Sinus Thrombosis Before And During Covid-19 Pandemic Era: A Single-Center Retrospective Cohort Study, Maryam Vasaghi Gharamaleki, Maryam Habibagahi, Etrat Hooshmandi, Reza Tabrizi, Shahram Arsang-Jang, Zohreh Barzegar, Nima Fadakar, Vahid Reza Ostovan, Abbas Rahimi-Jaberi, Nahid Ashjazadeh, Peyman Petramfar, Maryam Poursadeghfard, Sadegh Izadi, Masoumeh Nazeri, Hanieh Bazrafshan, Zahra Bahrami, Sedigheh Karimlu, Seyedeh Shaghayegh Zafarmand, Mahnaz Bayat, Mohammad Saied Salehi, Maryam Owjfard, Saeideh Karimi-Haghighi, Anahid Safari, Banafsheh Shakibajahromi, Beng Lim Alvin Chew, Bradford B.G. Worral, Jonathan M. Coutinho, Carlos Garcia-Esperon, Neil Spratt, M Reza Azarpazhooh
Neuroscience Institute Publications
Objectives: There are several reports of the association between SARS-CoV-2 infection (COVID-19) and cerebral venous sinus thrombosis (CVST). In this study, we aimed to compare the hospitalization rate of CVST before and during the COVID-19 pandemic (before vaccination program). Materials and methods: In this retrospective cohort study, the hospitalization rate of adult CVST patients in Namazi hospital, a tertiary referral center in the south of Iran, was compared in two periods of time. We defined March 2018 to March 2019 as the pre-COVID-19 period and March 2020 to March 2021 as the COVID-19 period. Results: 50 and 77 adult CVST …
Evidence-Based Considerations For The Design Of An Open-Source Ventilator: A Systematic Review, Chintan Dave, Asaanth Sivajohan, John Basmaji, Marat Slessarev
Evidence-Based Considerations For The Design Of An Open-Source Ventilator: A Systematic Review, Chintan Dave, Asaanth Sivajohan, John Basmaji, Marat Slessarev
Neuroscience Institute Publications
OBJECTIVE: To inform the design of open-source ventilators, we performed a systematic review of clinical practice guidelines (CPGs) to consolidate the evidence on mechanical ventilation strategies that result in improved patient-important outcomes for acute hypoxic respiratory failure. DATA SOURCES: We developed a search strategy to identify relevant CPGs from Ovid Medline, Ovid Medline In-Process & Other Non-Indexed Citations, Embase, the Cochrane Library, Mendeley, and Google scholar from 2010 to February 17, 2022. STUDY SELECTION: Using a two-step screening process with two independent reviewers, we included CPGs that made recommendations on mechanical ventilation strategies of interest. Guidelines that reported at least …
Potential Circumstances Associated With Moral Injury And Moral Distress In Healthcare Workers And Public Safety Personnel Across The Globe During Covid-19: A Scoping Review, Yuanxin Xue, Jillian Lopes, Kimberly Ritchie, Andrea M. D’Alessandro, Laura Banfield, Randi E. Mccabe, Alexandra Heber, Ruth A. Lanius, Margaret C. Mckinnon
Potential Circumstances Associated With Moral Injury And Moral Distress In Healthcare Workers And Public Safety Personnel Across The Globe During Covid-19: A Scoping Review, Yuanxin Xue, Jillian Lopes, Kimberly Ritchie, Andrea M. D’Alessandro, Laura Banfield, Randi E. Mccabe, Alexandra Heber, Ruth A. Lanius, Margaret C. Mckinnon
Neuroscience Institute Publications
Healthcare workers (HCWs) and public safety personnel (PSP) across the globe have continued to face ethically and morally challenging situations during the COVID-19 pandemic that increase their risk for the development of moral distress (MD) and moral injury (MI). To date, however, the global circumstances that confer risk for MD and MI in these cohorts have not been systematically explored, nor have the unique circumstances that may exist across countries been explored. Here, we sought to identify and compare, across the globe, potentially morally injurious or distressful events (PMIDEs) in HCWs and PSP during the COVID-19 pandemic. A scoping review …
Acute Ischaemic Stroke Associated With Sars-Cov-2 Infection In North America, Adam A. Dmytriw, Mahmoud Dibas, Kevin Phan, Aslan Efendizade, Johanna Ospel, Clemens Schirmer, Fabio Settecase, Manraj K.S. Heran, Anna Luisa Kühn, Ajit S. Puri, Bijoy K. Menon, Sanjeev Sivakumar, Askan Mowla, Daniel Vela-Duarte, Italo Linfante, Guilherme C. Dabus, Robert W. Regenhardt, Salvatore D'Amato, Joseph A. Rosenthal, Alicia Zha, Nafee Talukder, Sunil A. Sheth, Ameer E. Hassan, Daniel L. Cooke, Lester Y. Leung, Adel M. Malek, Barbara Voetsch, Siddharth Sehgal, Ajay K. Wakhloo, Mayank Goyal
Acute Ischaemic Stroke Associated With Sars-Cov-2 Infection In North America, Adam A. Dmytriw, Mahmoud Dibas, Kevin Phan, Aslan Efendizade, Johanna Ospel, Clemens Schirmer, Fabio Settecase, Manraj K.S. Heran, Anna Luisa Kühn, Ajit S. Puri, Bijoy K. Menon, Sanjeev Sivakumar, Askan Mowla, Daniel Vela-Duarte, Italo Linfante, Guilherme C. Dabus, Robert W. Regenhardt, Salvatore D'Amato, Joseph A. Rosenthal, Alicia Zha, Nafee Talukder, Sunil A. Sheth, Ameer E. Hassan, Daniel L. Cooke, Lester Y. Leung, Adel M. Malek, Barbara Voetsch, Siddharth Sehgal, Ajay K. Wakhloo, Mayank Goyal
Neuroscience Institute Publications
BACKGROUND: To analyse the clinical characteristics of COVID-19 with acute ischaemic stroke (AIS) and identify factors predicting functional outcome. METHODS: Multicentre retrospective cohort study of COVID-19 patients with AIS who presented to 30 stroke centres in the USA and Canada between 14 March and 30 August 2020. The primary endpoint was poor functional outcome, defined as a modified Rankin Scale (mRS) of 5 or 6 at discharge. Secondary endpoints include favourable outcome (mRS ≤2) and mortality at discharge, ordinal mRS (shift analysis), symptomatic intracranial haemorrhage (sICH) and occurrence of in-hospital complications. RESULTS: A total of 216 COVID-19 patients with AIS …
Healthcare Workers And Covid-19-Related Moral Injury: An Interpersonally-Focused Approach Informed By Ptsd, Andrea M. D'Alessandro, Kimberly Ritchie, Randi E. Mccabe, Ruth A. Lanius, Alexandra Heber, Patrick Smith, Ann Malain, Hugo Schielke, Charlene O'Connor, Fardous Hosseiny, Sara Rodrigues, Margaret C. Mckinnon
Healthcare Workers And Covid-19-Related Moral Injury: An Interpersonally-Focused Approach Informed By Ptsd, Andrea M. D'Alessandro, Kimberly Ritchie, Randi E. Mccabe, Ruth A. Lanius, Alexandra Heber, Patrick Smith, Ann Malain, Hugo Schielke, Charlene O'Connor, Fardous Hosseiny, Sara Rodrigues, Margaret C. Mckinnon
Neuroscience Institute Publications
The COVID-19 pandemic has resulted in a still-unfolding series of novel, potentially traumatic moral and ethical challenges that place many healthcare workers at risk of developing moral injury. Moral injury is a type of psychological response that may arise when one transgresses or witnesses another transgress deeply held moral values, or when one feels that an individual or institution that has a duty to provide care has failed to do so. Despite knowledge of this widespread exposure, to date, empirical data are scarce as to how to prevent and, where necessary, treat COVID-19-related moral injury in healthcare workers. Given the …
Effect Of Sedation With Inhaled Anaesthetics On Cognitive And Psychiatric Outcomes In Critically Ill Adults: A Systematic Review Protocol, Sean Cuninghame, Kevin Gorsky, Conall Francoeur, Davinia Withington, Lisa Burry, Angela Jerath, Marat Slessarev
Effect Of Sedation With Inhaled Anaesthetics On Cognitive And Psychiatric Outcomes In Critically Ill Adults: A Systematic Review Protocol, Sean Cuninghame, Kevin Gorsky, Conall Francoeur, Davinia Withington, Lisa Burry, Angela Jerath, Marat Slessarev
Neuroscience Institute Publications
Introduction The COVID-19 pandemic has renewed interest in the use of inhaled anaesthetics for sedation of ventilated critically ill patients. Preliminary data show that inhaled anaesthetics reduce lung inflammation, time to extubation and intensive care unit length of stay compared with intravenous sedatives. However, the impact of inhaled anaesthetics on cognitive and psychiatric outcomes is not well described in this setting. Randomised controlled trials are underway to establish if inhaled anaesthetics affect these and other patient and health system outcomes. Our aim is to summarise the known effects of inhaled sedatives on cognitive and psychiatric outcomes. Methods and analysis In …
The Use Of Cremation Data For Timely Mortality Surveillance During The Covid-19 Pandemic In Ontario, Canada: Validation Study, Gemma Postill, Regan Murray, Andrew S. Wilton, Richard A. Wells, Renee Sirbu, Mark J. Daley, Laura Rosella
The Use Of Cremation Data For Timely Mortality Surveillance During The Covid-19 Pandemic In Ontario, Canada: Validation Study, Gemma Postill, Regan Murray, Andrew S. Wilton, Richard A. Wells, Renee Sirbu, Mark J. Daley, Laura Rosella
Neuroscience Institute Publications
Background: Early estimates of excess mortality are crucial for understanding the impact of COVID-19. However, there is a lag of several months in the reporting of vital statistics mortality data for many jurisdictions, including across Canada. In Ontario, a Canadian province, certification by a coroner is required before cremation can occur, creating real-time mortality data that encompasses the majority of deaths within the province. Objective: This study aimed to validate the use of cremation data as a timely surveillance tool for all-cause mortality during a public health emergency in a jurisdiction with delays in vital statistics data. Specifically, this study …
Well-Being Of Canadian Veterans During The Covid-19 Pandemic: Cross-Sectional Results From The Covid-19 Veteran Well-Being Study, J. Don Richardson, Kate St Cyr, Callista Forchuk, Jenny J.W. Liu, Rachel A. Plouffe, Tri Le, Dominic Gargala, Erisa Deda, Vanessa Soares, Fardous Hosseiny, Patrick Smith, Gabrielle Dupuis, Maya Roth, Andrew Bridgen, Michelle Marlborough, Rakesh Jetly, Alexandra Heber, Ruth Lanius, Anthony Nazarov
Well-Being Of Canadian Veterans During The Covid-19 Pandemic: Cross-Sectional Results From The Covid-19 Veteran Well-Being Study, J. Don Richardson, Kate St Cyr, Callista Forchuk, Jenny J.W. Liu, Rachel A. Plouffe, Tri Le, Dominic Gargala, Erisa Deda, Vanessa Soares, Fardous Hosseiny, Patrick Smith, Gabrielle Dupuis, Maya Roth, Andrew Bridgen, Michelle Marlborough, Rakesh Jetly, Alexandra Heber, Ruth Lanius, Anthony Nazarov
Neuroscience Institute Publications
Background: The impacts of the COVID-19 pandemic have disproportionally affected different population groups. Veterans are more likely to have pre-existing mental health conditions compared to the general Canadian population, experience compounded stressors resulting from disruptions to familial, social, and occupational domains, and were faced with changes in health-care delivery (e.g. telehealth). The objectives of this study are to assess (a) the mental health impact of COVID-19 and related life changes on the well-being of Veterans and (b) perceptions of and satisfaction with changes in health-care treatments and delivery during the pandemic. Methods: A total of 1136 Canadian Veterans participated in …
Well-Being Of Canadian Armed Forces Veterans And Spouses Of Veterans During The Covid-19 Pandemic: Protocol For A Prospective Longitudinal Survey, Callista A. Forchuk, Anthony Nazarov, Rachel A. Plouffe, Jenny J.W. Liu, Erisa Deda, Tri Le, Dominic Gargala, Vanessa Soares, Jesse Bourret-Gheysen, Kate St Cyr, Maede S. Nouri, Fardous Hosseiny, Patrick Smith, Gabrielle Dupuis, Maya Roth, Michelle Marlborough, Rakesh Jetly, Alexandra Heber, Ruth Lanius, J. Don Richardson
Well-Being Of Canadian Armed Forces Veterans And Spouses Of Veterans During The Covid-19 Pandemic: Protocol For A Prospective Longitudinal Survey, Callista A. Forchuk, Anthony Nazarov, Rachel A. Plouffe, Jenny J.W. Liu, Erisa Deda, Tri Le, Dominic Gargala, Vanessa Soares, Jesse Bourret-Gheysen, Kate St Cyr, Maede S. Nouri, Fardous Hosseiny, Patrick Smith, Gabrielle Dupuis, Maya Roth, Michelle Marlborough, Rakesh Jetly, Alexandra Heber, Ruth Lanius, J. Don Richardson
Neuroscience Institute Publications
Background: The COVID-19 pandemic has resulted in significant changes to everyday life, including social distancing mandates, changes to health care, and a heightened risk of infection. Previous research has shown that Canadian Armed Forces (CAF) veterans are at higher risk of developing mental and physical health conditions. Veterans and their families may face unique social challenges that can compound with pandemic-related disruptions to negatively impact well-being. Objective: This study aims to longitudinally characterize the mental health of CAF veterans and spouses of CAF veterans throughout the pandemic and to understand the dynamic influences of pandemic-related stressors on psychological health over …