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Case Report: Inflammation And Endothelial Injury Profiling Of Covid-19 Pediatric Multisystem Inflammatory Syndrome (Mis-C), Douglas D. Fraser, Eric K. Patterson, Mark Daley, Gediminas Cepinskas

Brain and Mind Institute Researchers' Publications

Introduction: COVID-19 is associated with a novel multi-system inflammatory syndrome that shares some characteristics with Kawasaki's Disease. The syndrome manifestation is delayed relative to COVID-19 onset, with a spectrum of clinical severity. Clinical signs may include persistent fever, gastrointestinal symptoms, cardiac inflammation and/or shock. Case Presentation: We measured 59 inflammatory and endothelial injury plasma analytes in an adolescent girl that presented with malaise, fever, cough, strawberry tongue and jaundice. Her COVID-19 status was positive with detection of 2 SARS-CoV-2 viral genes using polymerase chain reaction. She was treated with intravenous immunoglobulin prior to blood draw, but our plasma measurements suggested …