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Articles 1 - 30 of 44
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Investigating The Effects Of Tissue-Specific Extracellular Matrix On The Adipogenic And Osteogenic Differentiation Of Human Adipose-Derived Stromal Cells Within Composite Hydrogel Scaffolds, Arthi Shridhar, Brian G. Amsden, Elizabeth R. Gillies, Lauren E. Flynn
Investigating The Effects Of Tissue-Specific Extracellular Matrix On The Adipogenic And Osteogenic Differentiation Of Human Adipose-Derived Stromal Cells Within Composite Hydrogel Scaffolds, Arthi Shridhar, Brian G. Amsden, Elizabeth R. Gillies, Lauren E. Flynn
Bone and Joint Institute
© Copyright © 2019 Shridhar, Amsden, Gillies and Flynn. While it has been postulated that tissue-specific bioscaffolds derived from the extracellular matrix (ECM) can direct stem cell differentiation, systematic comparisons of multiple ECM sources are needed to more fully assess the benefits of incorporating tissue-specific ECM in stem cell culture and delivery platforms. To probe the effects of ECM sourced from decellularized adipose tissue (DAT) or decellularized trabecular bone (DTB) on the adipogenic and osteogenic differentiation of human adipose-derived stem/stromal cells (ASCs), a novel detergent-free decellularization protocol was developed for bovine trabecular bone that complemented our established detergent-free decellularization protocol …
Patients Undergoing Surgery For Lumbar Spinal Stenosis Experience Unique Courses Of Pain And Disability: A Group-Based Trajectory Analysis, Jeffrey J. Hebert, Edward Abraham, Niels Wedderkopp, Erin Bigney, Eden Richardson, Mariah Darling, Hamilton Hall, Charles G. Fisher, Y. Raja Rampersaud, Kenneth C. Thomas, Bradley Jacobs, Michael Johnson, Jerome Paquet, Najmedden Attabib, Peter Jarzem, Eugene K. Wai, Parham Rasoulinejad, Henry Ahn, Andrew Nataraj, Alexandra Stratton, Neil Manson
Patients Undergoing Surgery For Lumbar Spinal Stenosis Experience Unique Courses Of Pain And Disability: A Group-Based Trajectory Analysis, Jeffrey J. Hebert, Edward Abraham, Niels Wedderkopp, Erin Bigney, Eden Richardson, Mariah Darling, Hamilton Hall, Charles G. Fisher, Y. Raja Rampersaud, Kenneth C. Thomas, Bradley Jacobs, Michael Johnson, Jerome Paquet, Najmedden Attabib, Peter Jarzem, Eugene K. Wai, Parham Rasoulinejad, Henry Ahn, Andrew Nataraj, Alexandra Stratton, Neil Manson
Bone and Joint Institute
© 2019 Hebert et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Objective Identify patient subgroups defined by trajectories of pain and disability following surgery for degenerative lumbar spinal stenosis, and investigate the construct validity of the subgroups by evaluating for meaningful differences in clinical outcomes. Methods We recruited patients with degenerative lumbar spinal stenosis from 13 surgical spine centers who were deemed to be surgical candidates. Study outcomes (leg and back pain …
Material Mapping Of Qct-Derived Scapular Models: A Comparison With Micro-Ct Loaded Specimens Using Digital Volume Correlation, Nikolas K. Knowles, Jonathan Kusins, Mohammadreza Faieghi, Melissa Ryan, Enrico Dall’Ara, Louis M. Ferreira
Material Mapping Of Qct-Derived Scapular Models: A Comparison With Micro-Ct Loaded Specimens Using Digital Volume Correlation, Nikolas K. Knowles, Jonathan Kusins, Mohammadreza Faieghi, Melissa Ryan, Enrico Dall’Ara, Louis M. Ferreira
Bone and Joint Institute
© 2019, The Author(s). Subject- and site-specific modeling techniques greatly improve finite element models (FEMs) derived from clinical-resolution CT data. A variety of density-modulus relationships are used in scapula FEMs, but the sensitivity to selection of relationships has yet to be experimentally evaluated. The objectives of this study were to compare quantitative-CT (QCT) derived FEMs mapped with different density-modulus relationships and material mapping strategies to experimentally loaded cadaveric scapular specimens. Six specimens were loaded within a micro-CT (33.5 μm isotropic voxels) using a custom-hexapod loading device. Digital volume correlation (DVC) was used to estimate full-field displacements by registering images in …
Psychometric Properties Of The Global Rating Of Change Scales In Patients With Neck Disorders: A Systematic Review With Meta-Analysis And Meta-Regression, Pavlos Bobos, Joy Macdermid, Goris Nazari, Rochelle Furtado
Psychometric Properties Of The Global Rating Of Change Scales In Patients With Neck Disorders: A Systematic Review With Meta-Analysis And Meta-Regression, Pavlos Bobos, Joy Macdermid, Goris Nazari, Rochelle Furtado
Bone and Joint Institute
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Objective The purpose of this systematic review was to critically appraise and synthesise the psychometric properties of Global Rating of Change (GROC) scales for assessment of patients with neck pain. Design Systematic review. Data sources A search was performed in four databases (MEDLINE, EMBASE, CINAHL, SCOPUS) until February 2019. Data extraction and synthesis Eligible articles were appraised using Consensus-based Standards for the selection of health Measurement Instruments checklist and the Quality Appraisal for Clinical Measurement Research Reports Evaluation Form. …
Systematic Review Of The Measurement Properties Of Performance-Based Functional Tests In Patients With Neck Disorders, Steven Mcgee, Taylor Sipos, Thomas Allin, Celia Chen, Alexandra Greco, Pavlos Bobos, Joy Macdermid
Systematic Review Of The Measurement Properties Of Performance-Based Functional Tests In Patients With Neck Disorders, Steven Mcgee, Taylor Sipos, Thomas Allin, Celia Chen, Alexandra Greco, Pavlos Bobos, Joy Macdermid
Bone and Joint Institute
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Objectives The purpose of this systematic review is to identify and synthesise studies evaluating performance-based functional outcome measures designed to evaluate the functional abilities of patients with neck pain. Design Systematic review. Data sources A literature search using PubMed, Scopus, CINAHL, EMBASE, COCHRANE, Google Scholar and a citation mapping strategy was conducted until July 2019. Eligibility criteria More than half of the study's patient population had neck pain or a musculoskeletal neck disorder and completed a functional-based test. Clinimetric …
Machine Learning Groups Patients By Early Functional Improvement Likelihood Based On Wearable Sensor Instrumented Preoperative Timed-Up-And-Go Tests, Riley A. Bloomfield, Harley A. Williams, Jordan S. Broberg, Brent A. Lanting, Kenneth A. Mcisaac, Matthew G. Teeter
Machine Learning Groups Patients By Early Functional Improvement Likelihood Based On Wearable Sensor Instrumented Preoperative Timed-Up-And-Go Tests, Riley A. Bloomfield, Harley A. Williams, Jordan S. Broberg, Brent A. Lanting, Kenneth A. Mcisaac, Matthew G. Teeter
Bone and Joint Institute
© 2019 The Author(s) Background: Wearable sensors permit efficient data collection and unobtrusive systems can be used for instrumenting knee patients for objective assessment. Machine learning can be leveraged to parse the abundant information these systems provide and segment patients into relevant groups without specifying group membership criteria. The objective of this study is to examine functional parameters influencing favorable recovery outcomes by separating patients into functional groups and tracking them through clinical follow-ups. Methods: Patients undergoing primary unilateral total knee arthroplasty (n = 68) completed instrumented timed-up-and-go tests preoperatively and at their 2-, 6-, and 12-week follow-up appointments. A …
Phosphonium Polyelectrolyte Complexes For The Encapsulation And Slow Release Of Ionic Cargo, Tristan D. Harrison, Olga Yunyaeva, Aneta Borecki, Cameron C. Hopkins, John R. De Bruyn, Paul J. Ragogna, Elizabeth R. Gillies
Phosphonium Polyelectrolyte Complexes For The Encapsulation And Slow Release Of Ionic Cargo, Tristan D. Harrison, Olga Yunyaeva, Aneta Borecki, Cameron C. Hopkins, John R. De Bruyn, Paul J. Ragogna, Elizabeth R. Gillies
Bone and Joint Institute
© 2019 American Chemical Society. Polyelectrolyte complexation, the combination of anionically and cationically charged polymers through ionic interactions, can be used to form hydrogel networks. These networks can be used to encapsulate and release cargo, but the release of cargo is typically rapid, occurring over a period of hours to a few days and they often exhibit weak, fluid-like mechanical properties. Here we report the preparation and study of polyelectrolyte complexes (PECs) from sodium hyaluronate (HA) and poly[tris(hydroxypropyl)(4-vinylbenzyl)phosphonium chloride], poly[triphenyl(4-vinylbenzyl)phosphonium chloride], poly[tri(n-butyl)(4-vinylbenzyl)phosphonium chloride], or poly[triethyl(4-vinylbenzyl)phosphonium chloride]. The networks were compacted by ultracentrifugation, then their composition, swelling, rheological, and self-healing properties …
Effects Of 6 Months Of Exercise-Based Cardiac Rehabilitation On Autonomic Function And Neuro-Cardiovascular Stress Reactivity In Coronary Artery Disease Patients, Mark B. Badrov, Katelyn N. Wood, Sophie Lalande, Carolyn P. Sawicki, Lindsay J. Borrell, Carly C. Barron, Jennifer L. Vording, Arlene Fleischhauer, Neville Suskin, Cheri L. Mcgowan, J. Kevin Shoemaker
Effects Of 6 Months Of Exercise-Based Cardiac Rehabilitation On Autonomic Function And Neuro-Cardiovascular Stress Reactivity In Coronary Artery Disease Patients, Mark B. Badrov, Katelyn N. Wood, Sophie Lalande, Carolyn P. Sawicki, Lindsay J. Borrell, Carly C. Barron, Jennifer L. Vording, Arlene Fleischhauer, Neville Suskin, Cheri L. Mcgowan, J. Kevin Shoemaker
Bone and Joint Institute
Background Autonomic dysregulation represents a hallmark of coronary artery disease (CAD). Therefore, we investigated the effects of exercise-based cardiac rehabilitation (CR) on autonomic function and neuro-cardiovascular stress reactivity in CAD patients. Methods and Results Twenty-two CAD patients (4 women; 62±8 years) were studied before and following 6 months of aerobic- and resistance-training-based CR. Twenty-two similarly aged, healthy individuals (CTRL; 7 women; 62±11 years) served as controls. We measured blood pressure, muscle sympathetic nerve activity, heart rate, heart rate variability (linear and nonlinear), and cardiovagal (sequence method) and sympathetic (linear relationship between burst incidence and diastolic blood pressure) baroreflex sensitivity during …
Performance Of Qct-Derived Scapula Finite Element Models In Predicting Local Displacements Using Digital Volume Correlation, Jonathan Kusins, Nikolas Knowles, Melissa Ryan, Enrico Dall'ara, Louis Ferreira
Performance Of Qct-Derived Scapula Finite Element Models In Predicting Local Displacements Using Digital Volume Correlation, Jonathan Kusins, Nikolas Knowles, Melissa Ryan, Enrico Dall'ara, Louis Ferreira
Bone and Joint Institute
© 2019 Subject-specific finite element models (FEMs)of the shoulder complex are commonly used to predict differences in internal load distribution due to injury, treatment or disease. However, these models rely on various underlying assumptions, and although experimental validation is warranted, it is difficult to obtain and often not performed. The goal of the current study was to quantify the accuracy of local displacements predicted by subject-specific QCT-based FEMs of the scapula, compared to experimental measurements obtained by combining digital volume correlation (DVC)and mechanical loading of cadaveric specimens within a microCT scanner. Four cadaveric specimens were loaded within a microCT scanner …
Determining Known-Group Validity And Test-Retest Reliability In The Peq (Personalized Exercise Questionnaire), Isabel B. Rodrigues, Jonathan D. Adachi, Karen A. Beattie, Arthur Lau, Joy C. Macdermid
Determining Known-Group Validity And Test-Retest Reliability In The Peq (Personalized Exercise Questionnaire), Isabel B. Rodrigues, Jonathan D. Adachi, Karen A. Beattie, Arthur Lau, Joy C. Macdermid
Bone and Joint Institute
© 2019 The Author(s). Background: To determine the known-group validity, a type of construct validity, and the test-retest reliability of a newly developed tool, the Personalized Exercise Questionnaire (PEQ), that assesses the barriers, facilitators, and preferences to exercise in individuals with low bone mass and osteoporosis. Methods: A comparative design was used to assess known-group validity and a test-retest design to examine the reproducibility. Ninety-five participants with low bone mass and osteoporosis were recruited from an outpatient clinic in Hamilton, Ontario. The questionnaire was administered to 95 participants at baseline and a subset of 42 participants completed the survey again …
Arthroscopy Association Of Canada Position Statement On Intra-Articular Injections For Knee Osteoarthritis, Michaela Kopka, Brendan Sheehan, Ryan Degen, Ivan Wong, Laurie Hiemstra, Olufemi Ayeni, Alan Getgood, Cole Beavis, Monika Volesky, Ross Outerbridge, Bogdan Matache
Arthroscopy Association Of Canada Position Statement On Intra-Articular Injections For Knee Osteoarthritis, Michaela Kopka, Brendan Sheehan, Ryan Degen, Ivan Wong, Laurie Hiemstra, Olufemi Ayeni, Alan Getgood, Cole Beavis, Monika Volesky, Ross Outerbridge, Bogdan Matache
Bone and Joint Institute
No abstract provided.
The Effect Of Wrist Position On Finger Tendon Loads Following Pulley Sectioning And Operative Reconstruction, Mohammad M. Haddara, B. Byers, Shrikant Chinchalkar, Louis M. Ferreira, Nina Suh
The Effect Of Wrist Position On Finger Tendon Loads Following Pulley Sectioning And Operative Reconstruction, Mohammad M. Haddara, B. Byers, Shrikant Chinchalkar, Louis M. Ferreira, Nina Suh
Bone and Joint Institute
© 2019 The Authors Purpose: Postoperative rehabilitation is important for maximizing patient outcomes after surgical pulley reconstruction. The purpose of this study was to identify the optimal wrist position in which rehabilitation should be undertaken to decrease the load on surgically reconstructed pulleys. Methods: We tested 14 digits composed of the index, middle, and ring fingers from 5 cadaveric specimens in a novel in vitro finger motion simulator designed to achieve full finger flexion and extension actively. Servo-motors were used to generate motion through tendons under load or position control while measuring tendon forces, joint range of motion, and tendon …
Lateral Compartment Contact Pressures Do Not Increase After Lateral Extra-Articular Tenodesis And Subsequent Subtotal Meniscectomy, Tomoyuki Shimakawa, Timothy A. Burkhart, Cynthia E. Dunning, Ryan M. Degen, Alan M. Getgood
Lateral Compartment Contact Pressures Do Not Increase After Lateral Extra-Articular Tenodesis And Subsequent Subtotal Meniscectomy, Tomoyuki Shimakawa, Timothy A. Burkhart, Cynthia E. Dunning, Ryan M. Degen, Alan M. Getgood
Bone and Joint Institute
© The Author(s) 2019. Background: Modified Lemaire lateral extra-articular tenodesis (LET) has been proposed as a method of addressing persistent anterolateral rotatory laxity after anterior cruciate ligament (ACL) reconstruction (ACLR). However, concerns remain regarding the potential for increasing lateral compartment contact pressures. Purpose: To investigate changes in tibiofemoral joint contact pressures after isolated ACLR and combined ACLR plus LET with varying states of a lateral meniscal injury. Study Design: Controlled laboratory study. Methods: Eight fresh-frozen cadaveric knee specimens (mean age, 60.0 ± 3.4 years) were utilized for this study, with specimens potted and loaded on a materials testing machine. A …
Maga Expression Attenuates Iron Export Activity In Undifferentiated Multipotent P19 Cells, Linshan Liu, Kobra Alizadeh, Sarah C. Donnelly, Praveen Dassanayake, Tian Tian Hou, Rebecca Mcgirr, R. Terry Thompson, Frank S. Prato, Neil Gelman, Lisa Hoffman, Donna E. Goldhawk
Maga Expression Attenuates Iron Export Activity In Undifferentiated Multipotent P19 Cells, Linshan Liu, Kobra Alizadeh, Sarah C. Donnelly, Praveen Dassanayake, Tian Tian Hou, Rebecca Mcgirr, R. Terry Thompson, Frank S. Prato, Neil Gelman, Lisa Hoffman, Donna E. Goldhawk
Bone and Joint Institute
© 2019 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Magnetic resonance imaging (MRI) is a non-invasive imaging modality used in longitudinal cell tracking. Previous studies suggest that MagA, a putative iron transport protein from magnetotactic bacteria, is a useful gene-based magnetic resonance contrast agent. Hem-agglutinin-tagged MagA was stably expressed in undifferentiated embryonic mouse teratocarcinoma, multipotent P19 cells to provide a suitable model for tracking these cells during differentiation. Western blot …
Effectiveness Of Home Fire Safety Interventions. A Systematic Review And Metaanalysis, Maya Senthilkumaran, Goris Nazari, Joy C. Macdermid, Karen Roche, Kim Sopko
Effectiveness Of Home Fire Safety Interventions. A Systematic Review And Metaanalysis, Maya Senthilkumaran, Goris Nazari, Joy C. Macdermid, Karen Roche, Kim Sopko
Bone and Joint Institute
© 2019 Senthilkumaran et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Purpose To assess the effectiveness of Home Fire Safety (HFS) interventions versus other interventions/ no interventions/controls on HFS knowledge and behaviour at short-, intermediateand long-term follow ups. Design Systematic review and meta-analysis of randomized controlled trials. Data sources MEDLINE, EMBASE and PubMed databases were searched from January 1998 to July 2018, and studies retrieved. Participants Toddlers, children (primary or secondary school), …
Mri T2 And T1Ρ Relaxation In Patients At Risk For Knee Osteoarthritis: A Systematic Review And Meta-Analysis, Hayden F. Atkinson, Trevor B. Birmingham, Rebecca F. Moyer, Daniel Yacoub, Lauren E. Kanko, Dianne M. Bryant, Jonathan D. Thiessen, R. Terry Thompson
Mri T2 And T1Ρ Relaxation In Patients At Risk For Knee Osteoarthritis: A Systematic Review And Meta-Analysis, Hayden F. Atkinson, Trevor B. Birmingham, Rebecca F. Moyer, Daniel Yacoub, Lauren E. Kanko, Dianne M. Bryant, Jonathan D. Thiessen, R. Terry Thompson
Bone and Joint Institute
© 2019 The Author(s). Background: Magnetic resonance imaging (MRI) T2 and T1ρ relaxation are increasingly being proposed as imaging biomarkers potentially capable of detecting biochemical changes in articular cartilage before structural changes are evident. We aimed to: 1) summarize MRI methods of published studies investigating T2 and T1ρ relaxation time in participants at risk for but without radiographic knee OA; and 2) compare T2 and T1ρ relaxation between participants at-risk for knee OA and healthy controls. Methods: We conducted a systematic review of studies reporting T2 and T1ρ relaxation data that included both participants at risk for knee OA and …
Appraisal Of Clinical Practice Guideline: Eular Revised Recommendations For The Management Of Fibromyalgia, Vanitha Arumugam, Joy C. Macdermid
Appraisal Of Clinical Practice Guideline: Eular Revised Recommendations For The Management Of Fibromyalgia, Vanitha Arumugam, Joy C. Macdermid
Bone and Joint Institute
No abstract provided.
Clinimetrics: Single Assessment Numeric Evaluation, Rochelle Furtado, Joy Macdermid
Clinimetrics: Single Assessment Numeric Evaluation, Rochelle Furtado, Joy Macdermid
Bone and Joint Institute
No abstract provided.
Measurement Properties Of The Sf-Mpq-2 Neuropathic Qualities Subscale In Persons With Crps: Validity, Responsiveness, And Rasch Analysis, Tara L. Packham, Debbie Bean, Malcolm H. Johnson, Joy C. Macdermid, Sharon Grieve, Candida S. Mccabe, R. Norman Harden
Measurement Properties Of The Sf-Mpq-2 Neuropathic Qualities Subscale In Persons With Crps: Validity, Responsiveness, And Rasch Analysis, Tara L. Packham, Debbie Bean, Malcolm H. Johnson, Joy C. Macdermid, Sharon Grieve, Candida S. Mccabe, R. Norman Harden
Bone and Joint Institute
© 2018 American Academy of Pain Medicine. All rights reserved. Objectives. The purpose of this study was to conduct classical psychometric evaluation and Rasch analysis on the Neuropathic Qualities subscale of the Short-Form McGill Pain Questionnaire-2 utilizing scores from persons with complex regional pain syndrome to consider reliability and person separation, validity (including unidimensionality), and responsiveness in this population. Methods. Secondary analysis of longitudinal data from persons with acute complex regional pain syndrome was utilized for analysis of the psychometric properties and fit to the Rasch model of the Neuropathic Qualities subscale. We followed an iterative process of Rasch analysis …
Clinical And Functional Impairment After Nonoperative Treatment Of Distal Biceps Ruptures, Christopher C. Schmidt, Brandon T. Brown, Daniel L. Schmidt, Michael P. Smolinski, Thomas Kotsonis, Kenneth J. Faber, Kraig S. Graham, Tyler J. Madonna, Patrick J. Smolinski, Mark Carl Miller
Clinical And Functional Impairment After Nonoperative Treatment Of Distal Biceps Ruptures, Christopher C. Schmidt, Brandon T. Brown, Daniel L. Schmidt, Michael P. Smolinski, Thomas Kotsonis, Kenneth J. Faber, Kraig S. Graham, Tyler J. Madonna, Patrick J. Smolinski, Mark Carl Miller
Bone and Joint Institute
© 2018 Journal of Shoulder and Elbow Surgery Board of Trustees Background: Clinical and functional impairment after nonoperative treatment of distal biceps ruptures is not well understood. The goal of this study was to measure patients’ perceived disability, kinematic adjustment, and forearm supination power after nonoperative treatment of distal biceps ruptures. Methods: Fourteen individuals after nonoperative treatment of distal biceps ruptures were matched to a control group of 18 uninjured volunteers. Both groups prospectively completed the Disabilities of the Arm, Shoulder and Hand (DASH), Single Assessment Numerical Evaluation (SANE), and Biceps Disability Questionnaire. Both performed a new timed isotonic supination …
Use Of The Corail Stem For Revision Total Hip Arthroplasty: Evaluation Of Clinical Outcomes And Cost, Thomas J. Wood, Mohammad Alzahrani, Jacquelyn D. Marsh, Lyndsay E. Somerville, Edward M. Vasarhelyi, Brent A. Lanting
Use Of The Corail Stem For Revision Total Hip Arthroplasty: Evaluation Of Clinical Outcomes And Cost, Thomas J. Wood, Mohammad Alzahrani, Jacquelyn D. Marsh, Lyndsay E. Somerville, Edward M. Vasarhelyi, Brent A. Lanting
Bone and Joint Institute
© 2019 Joule Inc. or its licensors. Background: With the growing number of total hip arthroplasty (THA) procedures performed, revision surgery is also proportionately increasing, resulting in greater health care expenditures. The purpose of this study was to assess clinical outcomes and cost when using a collared, fully hydroxyapatite-coated primary femoral stem for revision THA compared to commonly used revision femoral stems. Methods: We retrospectively identifed patients who underwent revision THA with a primary stem between 2011 and 2016 and matched them on demographic variables and reason for revision to a similar cohort who underwent revision THA. We extracted operative …
Radiographic Thresholds With Increased Odds Of A Poor Outcome Following Distal Radius Fractures In Patients Over 65 Years Old, Caitlin J. Symonette, Joy C. Macdermid, Ruby Grewal
Radiographic Thresholds With Increased Odds Of A Poor Outcome Following Distal Radius Fractures In Patients Over 65 Years Old, Caitlin J. Symonette, Joy C. Macdermid, Ruby Grewal
Bone and Joint Institute
© 2019 Purpose: Older patients (aged older than 65 years)appear to tolerate a great degree of anatomic deformity after DRFs; however, the threshold beyond which the deformity becomes unacceptable is unknown. The purposes of this study were to identify the acceptable threshold for radiographic parameters after DRFs in patients aged over 65 years according to a patient-rated pain and disability outcome measure and to determine whether baseline activity levels influenced these parameters. Methods: A cohort of 190 older adults (aged 65 years and older)with DRF were selected from an existing prospectively collected database. The influence of specific radiographic parameters (ulnar …
Antibacterial Activity Of Polymers: Discussions On The Nature Of Amphiphilic Balance, Edmund F. Palermo, Karen Lienkamp, Elizabeth R. Gillies, Paul J. Ragogna
Antibacterial Activity Of Polymers: Discussions On The Nature Of Amphiphilic Balance, Edmund F. Palermo, Karen Lienkamp, Elizabeth R. Gillies, Paul J. Ragogna
Bone and Joint Institute
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The purpose of this Viewpoint is to discuss the molecular design principles that guide development of synthetic antimicrobial polymers, especially those intended to mimic the structure of host defense peptides (HDPs). In particular, we focus on the principle of “amphiphilic balance” as it relates to some recently developed polyphosphoniums with somewhat atypical structure. We find that the fundamental concept of amphiphilic balance is still applicable to these new polymers, but that the method to achieve such balance is somewhat unique. We then briefly outline the future challenges and opportunities in this …
Closed Limb Fractures With Compromised Vascularization: A Narrative Review, Christopher Vannabouathong, Emil Schemitsch, Bradley Petrisor, Mohit Bhandari
Closed Limb Fractures With Compromised Vascularization: A Narrative Review, Christopher Vannabouathong, Emil Schemitsch, Bradley Petrisor, Mohit Bhandari
Bone and Joint Institute
© The Author(s) 2019. Vascular compromised fractures typically result in a high rate of healing complications, such as avascular necrosis, nonunion, delayed union, and arthritis, which severely affect a patient’s function and quality of life. The purpose of this review was to identify and describe the epidemiology and available treatment options for the most well-known vascular compromised closed fractures. The injuries discussed in detail in this review were scaphoid, lunate, femoral neck, and talar fractures. Current evidence suggests that optimal treatment for vascular compromised fractures is dependent on the degree of fracture displacement and comminution, and the patient’s post-injury functional …
Examination Of Psychological Risk Factors For Chronic Pain Following Cardiac Surgery: Protocol For A Prospective Observational Study, Michael H. Mcgillion, Shaunattonie Henry, Jason W. Busse, Carley Ouellette, Joel Katz, Manon Choinière, Andre Lamy, Richard Whitlock, Shirley Pettit, Jacqueline Hare, Krysten Gregus, Katheryn Brady, Nazari Dvirnik, Stephen Su Yang, Joel Parlow, Deborah Dumerton-Shore, Ian Gilron, D. Norman Buckley, Harsha Shanthanna, Sandra L. Carroll, Peter C. Coyte, Shanil Ebrahim, Wanrudee Isaranuwatchai, Denise N. Guerriere, Jeffrey Hoch, James Khan, Joy Macdermid, Geraldine Martorella, J. Charles Victor, Judy Watt-Watson, Kimberly Howard-Quijano, Aman Mahajan, Matthew T.V. Chan
Examination Of Psychological Risk Factors For Chronic Pain Following Cardiac Surgery: Protocol For A Prospective Observational Study, Michael H. Mcgillion, Shaunattonie Henry, Jason W. Busse, Carley Ouellette, Joel Katz, Manon Choinière, Andre Lamy, Richard Whitlock, Shirley Pettit, Jacqueline Hare, Krysten Gregus, Katheryn Brady, Nazari Dvirnik, Stephen Su Yang, Joel Parlow, Deborah Dumerton-Shore, Ian Gilron, D. Norman Buckley, Harsha Shanthanna, Sandra L. Carroll, Peter C. Coyte, Shanil Ebrahim, Wanrudee Isaranuwatchai, Denise N. Guerriere, Jeffrey Hoch, James Khan, Joy Macdermid, Geraldine Martorella, J. Charles Victor, Judy Watt-Watson, Kimberly Howard-Quijano, Aman Mahajan, Matthew T.V. Chan
Bone and Joint Institute
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. INTRODUCTION: Approximately 400 000 Americans and 36 000 Canadians undergo cardiac surgery annually, and up to 56% will develop chronic postsurgical pain (CPSP). The primary aim of this study is to explore the association of pain-related beliefs and gender-based pain expectations on the development of CPSP. Secondary goals are to: (A) explore risk factors for poor functional status and patient-level cost of illness from a societal perspective up to 12 months following cardiac surgery; and (B) determine the impact …
Anatomic Posterolateral Corner Reconstruction Using Single Graft Plus Adjustable-Loop Suspensory Fixation Device, Ryan Wood, James Robinson, Alan Getgood
Anatomic Posterolateral Corner Reconstruction Using Single Graft Plus Adjustable-Loop Suspensory Fixation Device, Ryan Wood, James Robinson, Alan Getgood
Bone and Joint Institute
© 2018 Arthroscopy Association of North America The original description of the LaPrade technique for anatomic posterolateral corner reconstruction addresses the 3 main stabilizing structures: the fibular collateral ligament, the popliteus, and the popliteofibular ligament. The use of two separate grafts (originally described with a tendo-Achilles allograft) may restrict the utility of the technique when sources of allograft may be limited and autografts must be used, particularly in the context of multiligament reconstruction. We present a modification of the technique, in which an adjustable cortical button is used for tibial fixation, which allows for the use of a single graft …
A Comparison Of The Polytomous Rasch Analysis Output Of Rumm2030 And R (Ltm/Erm/Tam/Lordif), Michael Robinson, Andrew M. Johnson, David M. Walton, Joy C. Macdermid
A Comparison Of The Polytomous Rasch Analysis Output Of Rumm2030 And R (Ltm/Erm/Tam/Lordif), Michael Robinson, Andrew M. Johnson, David M. Walton, Joy C. Macdermid
Bone and Joint Institute
© 2019 The Author(s). Background: Patient-reported outcome measures developed using Classical Test Theory are commonly comprised of ordinal level items on a Likert response scale are problematic as they do not permit the results to be compared between patients. Rasch analysis provides a solution to overcome this by evaluating the measurement characteristics of the rating scales using probability estimates. This is typically achieved using commercial software dedicated to Rasch analysis however, it is possible to conduct this analysis using non-specific open source software such a R. Methods: Rasch analysis was conducted using the most commonly used commercial software package, RUMM …
Comparison Of Cpg's For The Diagnosis, Prognosis And Management Of Non-Specific Neck Pain: A Systematic Review, Pulak Parikh, Pasqualina Santaguida, Joy Macdermid, Anita Gross, Arshia Eshtiaghi
Comparison Of Cpg's For The Diagnosis, Prognosis And Management Of Non-Specific Neck Pain: A Systematic Review, Pulak Parikh, Pasqualina Santaguida, Joy Macdermid, Anita Gross, Arshia Eshtiaghi
Bone and Joint Institute
© 2019 The Author(s). Background: Neck pain (NP) is a very common musculoskeletal condition with potential for a high burden in disability and length of disorder. Clinical practice guidelines (CPG) give recommendations to clinicians for providing optimal care for patients however best practice recommendations are often contradictory. The purpose for this review was to conduct a SR of CPGs to assess the management recommendations for NP (diagnosis, treatment, prognosis, imaging). Methods: Standard SR methodology was employed including a grey literature search (including the National Guideline Clearing House). Medline, Cinahl, Embase, ILC, Cochrane, Central, and Lilacs were searched from 1995-to March …
Understanding The Patellofemoral Joint In Total Knee Arthroplasty, Jacob Matz, Brent A. Lanting, James L. Howard
Understanding The Patellofemoral Joint In Total Knee Arthroplasty, Jacob Matz, Brent A. Lanting, James L. Howard
Bone and Joint Institute
© 2019 Joule Inc. or its licensors. Total knee arthroplasty (TKA) is one of the most successful procedures in orthopedic surgery. Nevertheless, postoperative patellofemoral complications remain a challenging problem, affecting a substantial proportion of patients. Complications involving the patellofemoral joint (PFJ) can occur in both resurfaced and nonresurfaced patellae. Types of PFJ complications include anterior knee pain, maltracking, fracture, avascular necrosis and patellar clunk. The causes of patellofemoral complications can be categorized into patient-, surgeon- and implant-related factors. Patient characteristics such as female sex, young age, depression and increased body mass index have been linked with increased complications. Important technical …
Significant Cost Savings And Similar Patient Outcomes Associated With Early Discharge Following Total Knee Arthroplasty, Jacquelyn Marsh, Lyndsay Somerville, James L. Howard, Brent A. Lanting
Significant Cost Savings And Similar Patient Outcomes Associated With Early Discharge Following Total Knee Arthroplasty, Jacquelyn Marsh, Lyndsay Somerville, James L. Howard, Brent A. Lanting
Bone and Joint Institute
© 2019 Joule Inc. or its licensors. Background: A substantial portion of the cost of total knee arthroplasty (TKA) results from the postoperative inpatient length of stay (LOS). Considering the annual increase in TKAs, reducing LOS represents a potential for cost savings. We sought to compare in-hospital costs and patient-reported outcomes for an early discharge protocol compared with the standard LOS following TKA. Methods: We conducted a retrospective matched cohort study, matching patients on age, sex, body mass index and preoperative Western Ontario & McMaster Universities Osteoarthritis Index (WOMAC) score. We compared costs associated with time in the operating room, …