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Contribution Of Monoaminergic Mechanisms To The Discriminative Stimulus Effects Of 3,4-Methylenedioxypyrovalerone (Mdpv) In Sprague-Dawley Rats, Harmony I. Risca
Contribution Of Monoaminergic Mechanisms To The Discriminative Stimulus Effects Of 3,4-Methylenedioxypyrovalerone (Mdpv) In Sprague-Dawley Rats, Harmony I. Risca
Masters Theses
3,4-Methylenedioxypyrovalerone (MDPV) is a popular synthetic cathinone reported to have a high abuse potential and comparable pharmacological actions to those of cocaine. The aim of this study was to evaluate a variety of monoaminergic agents for substitution, potentiation, or antagonism in rats trained to discriminate MDPV. Male Sprague-Dawley rats were trained to discriminate 0.5 mg/kg MDPV and a variety of monoaminergic drugs were tested for substitution and/or potentiation of the MDPV cue. In separate experiments, stimulus antagonism tests were conducted with selected dopamine antagonists or serotonin antagonists in rats trained to discriminate 1 mg/kg MDPV. Full substitution for MDPV was …