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Exercise Ameliorates Disruption Of The Dystrophin-Associated Glycoprotein Complex And Fibrosis In The Aging Rat Heart, Yang Lee, Jeffrey M. Hord, Hyo-Bum Kwak, Jong-Hee Kim, John M. Lawler
Exercise Ameliorates Disruption Of The Dystrophin-Associated Glycoprotein Complex And Fibrosis In The Aging Rat Heart, Yang Lee, Jeffrey M. Hord, Hyo-Bum Kwak, Jong-Hee Kim, John M. Lawler
International Journal of Exercise Science: Conference Proceedings
The dystrophin-glycoprotein complex (DGC) is localized and integrated into the cell membrane. The DGC provides a mechanical link between the cellular cytoskeleton and the extracellular matrix (ECM). In cardiac muscle, disruption of DGC might be involved in mediating cardiac remodeling that occurs with aging, cardiomyopathy, and heart failure through transforming growth factor-beta (TGF-ß). Decorin is a small leucine-rich proteoglycan closely related to the DGC component that binds to collagen. Decorin reduces fibrosis via inhibition of TGF-ß and myofibroblast formation. PURPOSE: To test the hypothesis that exercise training (ET) would alleviate age-related disruption of localization in DGC proteins (dystrophin, α-syntrophin, and …
Influence Of Fitness And Adiposity On Melanocortin-1 And Melanocortin-3 Receptors On Monocytes., Matthew Unthank, Jonathan Woodson, Jason Butler, Gregory Bratton, James Barbee, Michael Chumley, Dennis Cheek, Joel Mitchell, Melody Phillips
Influence Of Fitness And Adiposity On Melanocortin-1 And Melanocortin-3 Receptors On Monocytes., Matthew Unthank, Jonathan Woodson, Jason Butler, Gregory Bratton, James Barbee, Michael Chumley, Dennis Cheek, Joel Mitchell, Melody Phillips
International Journal of Exercise Science: Conference Proceedings
Purpose: While it is known that exercise improves health by reducing systemic inflammation, potential mechanisms remain to be elucidated. The purpose of this study is to examine the influence of fitness and adiposity on the anti-inflammatory melanocortin system as a potential mechanism by which exercise reduces inflammation. Methods: Forty-one men and women (35-55yr), who were free from cardiovascular disease, inflammatory disorders, and not taking medications that affect inflammation, were recruited. Participants were questioned about exercise habits and medical history; then completed testing for body composition and aerobic fitness (VO2max). Subjects were classified as lean/fit (LF, n=14), overweight/fit (OF, …
Changes In Markers Of Muscle Damage After Half-Ironman Triathlon, Marcos Bürger-Mendonça, Fernanda Coutinho Retondaro-Barbosa, Raquel Carius Da Silveira, Denisvaldo Vieira Silveira
Changes In Markers Of Muscle Damage After Half-Ironman Triathlon, Marcos Bürger-Mendonça, Fernanda Coutinho Retondaro-Barbosa, Raquel Carius Da Silveira, Denisvaldo Vieira Silveira
International Journal of Exercise Science: Conference Proceedings
Triathlon is a unique endurance sport that comprises a sequential swim, swim-to cycle transition, cycle, cycle-to-run transition, and run. The aim of present was to analyze the effect of half-ironman triathlon over biochemistry parameters related of muscle damage. Six well-trained male amateurs’ triathletes who completed the 2004 half-ironman triathlon participated in the study. Blood samples from six athletes were collected before and immediately after the triathlon competition. Creatinine kinase (CK) and lactate dehydrogenase (LDH) were measured. Pre and post race values were compared by paired t-tests. Significant changes after triathlon completion were found for CK (P= 0.001) and LDH (P= …
Plasmatic E-Selectin Levels Were Decreased In Young Women With Metabolic Syndrome After Exercise Training, M Rosety-Rodriguez, I Rosety, G Fornieles-Gonzalez, J Meletis
Plasmatic E-Selectin Levels Were Decreased In Young Women With Metabolic Syndrome After Exercise Training, M Rosety-Rodriguez, I Rosety, G Fornieles-Gonzalez, J Meletis
International Journal of Exercise Science: Conference Proceedings
Cellular adhesion molecules (CAMs) such as E-selectin are involved in the rolling, adhesion and extravasation of monocytes into the atherosclerotic plaque. Fortunately regular exercise may improve pro-inflammatory status in individuals with metabolic syndrome. Accordingly, this study was designed to determine the influence of exercise on soluble plasmatic E-selectin levels in women with metabolic syndrome. Sixty adult women with metabolic syndrome according to the criteria reported by the National Cholesterol Education Program Adult Treatment Panel III volunteered for this study. Fourty-five were randomly included in experimental group to perform a 12-weeks aerobic training program, 3 days/week, consisting of warm up (10-min), …
Reduced Lipoperoxidation In High-Performance Athletes With Mental Retardation By A Mixed Protocol Based On Exercise And Supplementation, J F. Ordoñez, I Rosety, A Diaz, M A. Rosety
Reduced Lipoperoxidation In High-Performance Athletes With Mental Retardation By A Mixed Protocol Based On Exercise And Supplementation, J F. Ordoñez, I Rosety, A Diaz, M A. Rosety
International Journal of Exercise Science: Conference Proceedings
Individuals with mental retardation generally present high levels of oxidative stress. Further it is widely accepted that high physical performance may be associated to oxidative damage. The present study was undertaken to ascertain the influence of a mixed protocol based on regular exercise and antioxidant supplementation in lipoperoxidation in athletes with mental retardation. Fifty-five high-performance athletes with mental retardation from Special Olympics volunteered for this study (21.6±1.8 years-old). Fourty were randomly included in experimental group to perform a 6-weeks protocol, including exercise (low-moderate intensity aerobic exercise before breakfast 3 times per week) and supplementation (1g ascorbic acid + 400 UI …
A Previous Note Regarding The Influence Of A 6-Weeks Mixed Protocol On Plasmatic Carbonyl Groups In High-Performance Athletes With Mental Retardation, J F. Ordonez, I Rosety, M Bernardi, A Diaz
A Previous Note Regarding The Influence Of A 6-Weeks Mixed Protocol On Plasmatic Carbonyl Groups In High-Performance Athletes With Mental Retardation, J F. Ordonez, I Rosety, M Bernardi, A Diaz
International Journal of Exercise Science: Conference Proceedings
It is widely accepted that high physical performance may be associated to oxidative damage. The present study was undertaken to ascertain the influence of a mixed protocol based on regular exercise and antioxidant supplementation in plasmatic carbonyl group content in athletes with mental retardation. Mainly if we take into account individuals with mental retardation generally present high levels of oxidative damage. Fifty-five high-performance athletes with mental retardation from Special Olympics volunteered for this study (21.6±1.8 years-old). Fourty were randomly included in experimental group to perform a 6-weeks protocol including exercise (low-moderate intensity aerobic exercise before breakfast 3 times per week) …
Exercise Improves Endothelial Dysfunction In Young Women With Metabolic Syndrome, G Fornieles-Gonzalez, I Rosety, J Meletis, M A. Rosety
Exercise Improves Endothelial Dysfunction In Young Women With Metabolic Syndrome, G Fornieles-Gonzalez, I Rosety, J Meletis, M A. Rosety
International Journal of Exercise Science: Conference Proceedings
Recent studies have reported that regular exercise reduces pro-inflammatory biomarkers in women with metabolic syndrome. However, to date little information is available on the influence of exercise on endothelial dysfunction, despite its important role during the development of atherosclerotic plaque. Accordingly, this study was designed to determine the influence of exercise on soluble vascular cell adhesion molecule (VCAM-1) in women with metabolic syndrome. Sixty adult women with metabolic syndrome according to the criteria reported by the National Cholesterol Education Program Adult Treatment Panel III volunteered for this study. Fourty-five were randomly included in experimental group to perform a 12-weeks aerobic …