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Using Gain Of Function Genetics To Explore The Role Of Non-Histone Chromosomal Protein D1 In Drosophila Melanogaster, Marissa B. Smith
Using Gain Of Function Genetics To Explore The Role Of Non-Histone Chromosomal Protein D1 In Drosophila Melanogaster, Marissa B. Smith
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The organization of eukaryotic genomes requires a harmony between efficient compaction and accessibility. This is achieved through the packaging of chromatin and the influence of chromosomal proteins, a topic not well understood. A chromosomal protein that remains a mystery at present is the D1 protein. Identified in 1974 by Alfageme et al., D1 has been highly characterized but its function remains unknown. The goal of this study was to elucidate the function of D1 by overexpression analysis using the GAL4/UAS system in Drosophila melanogaster. Analysis of gain-of-function phenotypes due to D1 overexpression in a variety of tissues determined that ectopic …