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Oral Cbd Administration: Assessing Bioavailability And Behavioral Outcomes In A Rodent Model, Jordan Skully
Oral Cbd Administration: Assessing Bioavailability And Behavioral Outcomes In A Rodent Model, Jordan Skully
Wayne State University Theses
There has been a recent surge in popularity for cannabidiol (CBD), a major non-psychotropic constituent of cannabis, due to numerous claims of potential therapeutic properties, which include, but are not limited to, anxiolytic, antinociceptive, and anti-inflammatory effects. However, as previous scientific literature on CBD's effectiveness in providing such therapeutic effects is limited, this project was aimed to evaluate the potential beneficial properties of a hemp derived 99% pure CBD compound provided from Ellipse Analytics (Denver, CO) in a rodent model. We analyzed the pharmacokinetics of this CBD product as well as the behavioral outcomes after acute and chronic administration. Pharmacokinetics …
Analgesia Followed By Long-Term Hyperalgesia Generated By Disinhibition Of The Basolateral Amygdala, Derek Atchley
Analgesia Followed By Long-Term Hyperalgesia Generated By Disinhibition Of The Basolateral Amygdala, Derek Atchley
Wayne State University Theses
Stress produces bimodal effects on pain peception. During exposure to a stressor pain responses are inibited (i.e. stress-induced analgesia). However, following long-term exposure to a stressor increases in responsiveness to painful stimuli may develop (i.e. stress-induced hyperalgesia). Here I evaluated how a key component of the subcortical defense circuit and target of stress hormones contributes to the development of both stress-induced analgesia and hyperalgesia. Bicuculline methiodide, a GABAA antagonist, injected into the basolateral amygdala was used to mimic the neural effects of a stressor or threat exposure. Immediately following injection pain responsiveness was decreased as measured by vocalizations after discharge …
Great Expectations: How Are Couples Influenced By Threatening Information Prior To A Pain Task?, Angelia Marie Corley
Great Expectations: How Are Couples Influenced By Threatening Information Prior To A Pain Task?, Angelia Marie Corley
Wayne State University Theses
The present study examines the effects of a threat manipulation on romantic partners, in which one partner is about to undergo a painful task. Couples were randomly assigned to high and low threat manipulation groups, designed to alter one's anxiety or fear about the task. The study broadened the theoretical model, the Fear Avoidance Model, to the incorporate the social context and derived hypotheses regarding the role of one's romantic partner in the present paradigm. Results demonstrated preliminary evidence that a romantic partner may reduce one's anxiety about a painful task. Additionally, satisfaction with a conversation with a intimate partner …