Digital Commons Network^™

Unified Role Assignment Framework For Wireless Sensor Networks, Manish Mahendra Kumar Kochhal

Wayne State University Dissertations

Wireless sensor networks are made possible by the continuing improvements in embedded sensor, VLSI, and wireless radio technologies. Currently, one of the important challenges in sensor networks is the design of a systematic network management framework that allows localized and collaborative resource control uniformly across all application services such as sensing, monitoring, tracking, data aggregation, and routing.

The research in wireless sensor networks is currently oriented toward a cross-layer network abstraction that supports appropriate fine or course grained resource controls for energy efficiency. In that regard, we have designed a unified role-based service paradigm for wireless sensor networks. We pursue …

The Social Interactions Of Students With Disabilties In A 5th Grade Level Inclusive Classroom And The Effect On Academic Achievement, Estella Marshall-Reed

Wayne State University Dissertations

No abstract provided.

Enzymology And Medicinal Chemistry Of N5-Carboxyaminoimidazole Ribonucleotide Synthetase : A Novel Antibacterial Target, Hanumantharao Paritala

Wayne State University Dissertations

N5-Carboxyaminoimidazole ribonucleotide synthetase (N5-CAIR synthetase), a key enzyme in microbial de novo purine biosynthesis, catalyzes the conversion of aminoimidazole ribonucleotide (AIR) to N5-CAIR. To date, this enzyme has been observed only in microorganisms, and thus, it represents an ideal target for antimicrobial drug development. Here we report structural and functional studies on the Aspergillus clavatus N5-CAIR synthetase and identification of inhibitors for the enzyme. In collaboration with Dr. Hazel Holden of the University of Wisconsin, the three-dimensional structure of Aspergillus clavatus N5-CAIR synthetase was solved in the presence of either Mg2ATP or MgADP and AIR. These structures, determined to 2.1 …

A Study Of The Associations Between Childhood Obesity And Three Forms Of Social Capital, Cynthia Bala-Brusilow

Wayne State University Dissertations

Purpose: The purpose of the study was to expand the understanding of childhood obesity in American children by examining the associations between obesity in children and measures of social capital.

Context: Persons between 2 and 20 years of age are categorized as "obese" if their BMI is in 95th percentile or above for their age and sex using the Center for Disease Control and Prevention (CDC) BMI-for-age growth charts. Obesity prevalence has more than quadrupled in the last 40 years in the United States for children. Social capital, in the study of health, can be defined as resources accrued and/or …

Photodissociation Dynamics In Titan's Atmosphere, Welvidanalage Ruchira Silva

Wayne State University Dissertations

Photodissociation dynamics of molecules relevant to understanding Titan's atmosphere (diacetylene, cyanoacetylene and heptane isomers) are carried out under collisionless condition using the DC slice imaging technique. In diacetylene photodissociation, two-photon processes dominate at 243 nm and 212 nm whereas at 121.6 nm, a one-photon dissociation process dominates. Direct measurement of the lifetime of metastable triplet diacetylene confirms sub-microsecond lifetimes. Photodissociation of cyanoacetylene at 193.3 nm proceeds on the S1 potential energy surface with an exit barrier. In heptane photodissociation, the dissociation occurs on the ground state or low-lying triplet states with nonradiative electronic relaxation. Time-of-flight mass spectroscopy studies in this …

The Impact Of Self-Efficacy, Locus Of Control, And Perceived Parental Influence On The Academic Performance Of Low And High Achieving African-American High School Students, Frances Ernestine Curtis-Fields

Wayne State University Dissertations

The purpose of this study was to investigate the impact of self-efficacy, locus of control, and perceived parental influence on the academic achievement of African-American high school students from low socioeconomic levels. A nonexperimental, descriptive research study was used to collect the data needed to address the research questions posed for this study. High school students enrolled in one high school in a large urban school district were asked to participate in the study. These students completed three instruments, Self in School, Importance of Parent Involvement, and the Intellectual Achievement Responsibility questionnaire (IAR), along with a short demographic survey developed …

The Effects Of Gestalt And Cognitive-Behavioral Therapy Group Interventions On The Assertiveness And Self-Esteem Of Women With Physical Disabilities Facing Abuse, Cilene Susan Adam Rita

Wayne State University Dissertations

The purpose of this study was to examine the differential effects of Gestalt and Cognitive-Behavioral group therapy interventions on assertiveness and self-esteem among women with physical disabilities facing abuse. The eleven women, who met the study criteria, were randomly assigned to one of two experimental conditions, Gestalt Therapy (GT) and Cognitive-Behavioral Therapy (CBT) group interventions. The Demographic Questionnaire (Adam Rita, 2009) documented personal characteristics of the participants. The criterion instruments were: a) RAS (Rathus, 1973), and b) CFSEI-2 (Form AD, Battle, 1992) measuring assertiveness and self-esteem respectively and were administered pre-and-post treatment. The research was conducted over a period of …

Distributed Cinema: Interactive, Networked Spectatorship In The Age Of Digital Media, Erik Wayne Marshall

Wayne State University Dissertations

Digital media has changed much of how people watch, consume and interact with digital media. The loss of indexicality, or the potential infidelity between an image and its source, contributes to a distrust of images. The ubiquity of interactive media changes aesthetics of images, as viewers begin to expect interactivity. Networked media changes not only the ways in which viewers access media, but also how they communicate with each other about this media. The Tulse Luper Suitcases encapsulates all of these phenomena.

Activation Of Tumor Cell Death Program By Targeting The Ubiquitin-Proteasome Pathway: Significance In Cancer Treatment And Prevention, Michael Joseph Frezza

Wayne State University Dissertations

ACTIVATION OF TUMOR CELL DEATH PROGRAM BY TARGETING THE UBIQUITIN-PROTEASOME PATHWAY: SIGNIFICANCE IN CANCER TREATMENT AND PREVENTION

by

MICHAEL FREZZA

August 2010

Advisor: Dr. Q. Ping Dou

Major: Cancer Biology

Degree: Doctor of Philosophy

The ubiquitin-proteasome pathway serves as a quality control mechanism to regulate the degradation of intracellular proteins involved in a wide array of cellular processes including tumorigeneis. Thus targeting key features of protein turnover responsible for the growth and proliferation of cancer have emerged as a favorable approach in cancer therapy. Both in vitro and in vivo experimental and clinical results have demonstrated the potential use of …

The Effects Of Web-Based Interactive Emotional Disclosure On Stress And Health: A Randomized, Controlled Study, Jonathan Beyer

Wayne State University Dissertations

The purpose of this study was to develop and assess the relative effectiveness of two novel alternatives to standard written emotional disclosure for coping with stressful traumatic experiences. In addition to standard emotional disclosure and time management writing control conditions, two guided feedback conditions were created with a goal of enhancing the disclosure paradigm by eliciting the most effective components of disclosure writing. All of the writing conditions in the study utilized the internet for both completion of the writing and receipt of feedback in the indicated conditions. The guided conditions included a feedback writing condition in which guidance was …

Evaluating Outcomes And Response Profiles Of A Psychological Treatment For People With Chronic Pain, Amanda J. Burger

Wayne State University Dissertations

Chronic pain is a leading cause of suffering, disability, and high health care costs. Traditional treatment approaches such as medical or cognitive-behavioral interventions have produced variable and often limited results. Research has suggested

that increased rates of stressful life events, emotional disorders, and emotion regulation deficits contribute to the development and maintenance of chronic pain problems that lack clear, peripheral, biological causes. This study examined the effectiveness of an

innovative, emotion-focused treatment that directly targets patients' unresolved stress and emotional avoidance and sought to identify predictors of treatment outcome. Additionally, this study explored the effects of a novel, emotional assessment …

A Comparative Study Of Robert Lewis, Lee Strasberg, Stella Adler And Sanford Meisner In The Context Of Current Research About The Stanislavsky System, Ruthel Honey-Ellen Darvas

Wayne State University Dissertations

Decades of interpretation based on incorrect and incomplete information regarding Stanislavsky and his System have erroneously guided the advent of modern acting theory in the United States. This study, using current research about the Stanislavsky System, examines four notable acting teachers--Robert Lewis, Lee Strasberg, Stella Adler and Sanford Meisner--to determine whose philosophy most accurately reflects the Stanislavsky System as it is now understood. The concepts of action, imagination, bits, tasks, emotion memory and active analysis are each explored independently. Each concept is examined as it relates to the System and then compared to the concepts as interpreted and put into …

The Cultural Memory Of German Victimhood In Post-1990 Popular German Literature And Television, Pauline Ebert

Wayne State University Dissertations

My dissertation analyzes the representation of Germans as victims of the Third Reich and the Second World War in post-1990 German memory. After unification, there no longer were two states that could each blame the other as the heir of National Socialism and this past had to be renegotiated. The claim that many Germans had been victims became central as evidenced by the vast number of popular literature, commercial cinema and television programs of this subject. I argue with Wulf Kansteiner (2006) that to understand collective memory, we should explore mass media representations. As the majority of highbrow artifacts do …

Imaging The Vasculature With Susceptibility Weighted Imaging: Applications And Analysis, Samuel Barnes

Wayne State University Dissertations

Modern magnetic resonance imaging sequences allow detailed non-invasive imaging of both the arteries and veins. This work is divided into four sections that examine different applications and analysis of these sequences.

Susceptibility weighted imaging (SWI) typically generates excellent negative venous contrast. Techniques to generate positive arterial contrast in SWI images without degrading the venous contrast with a single echo are examined. By using high isotropic resolution and high readout bandwidth flow losses can be minimized (generating good arterial contrast) even at the long echo times required for good venous contrast. A downsampling filter is then used to restore lost venous …

Molecular Mechanisms Of Pressure-Stimulated Cancer Cell Signaling, Christina Downey

Wayne State University Dissertations

ABSTRACT

MOLECULAR MECHANISMS OF PRESSURE-STIMULATED CANCER CELL SIGNALING

by

CHRISTINA DOWNEY

June 2010

Advisor: Dr. Marc Basson, MD, PhD

Major: Cancer Biology

Degree: Doctor of Philosophy

Increased extracellular pressure stimulates cancer cell adhesion by a mechanism that is dependent upon beta-1-integrin activation, an intact cytoskeleton, and FAK and Src activation. By a different mechanism, increased extracellular pressure modulates cancer cell proliferation in a manner that is regulated by protein kinase C, but not Src or an intact cytoskeleton. Previous studies from our laboratory have shown that paxillin is a necessary mediator in the pathway by which pressure stimulates adhesion; however, …

Molecular And Therapeutic Implications Of Notch1 Signaling In Pediatric T-Cell Acute Lymphoblastic Leukemia, Amanda Larson Gedman

Wayne State University Dissertations

T-cell acute lymphoblastic leukemia (T-ALL) accounts for 15% of pediatric ALL cases and is associated with early relapse and inferior outcome. The poorer prognosis of T-ALL compared to B-precursor ALL may in part reflect the lack of unique features on which to base therapy. NOTCH1 mutations are of particular interest since these were reported in 37-71% of T-ALLs. The prognostic value of NOTCH1 mutations remains controversial as both favorable and unfavorable associations were reported, whereas in other studies, there were no associations between NOTCH1 mutations and treatment outcome. We explored the impact of mutations in NOTCH1, FBW7 and PTEN on …

Two Particle Correlations And The Ridge In Relativistic Heavy Ion Collisions, George Stevens Moschelli

Wayne State University Dissertations

Measurements at the Relativistic Heavy Ion Collider (RHIC) find an enhancement of two particle correlations in relativistic heavy ion collisions, not present in proton-proton collisions. Because the correlation structure is wide in relative pseudorapidity and narrow in relative azimuthal angle, it is known as the ridge. The most striking feature of the ridge is that it seems to extend to a long range in relative pseudorapidity where causality limits interaction. Similar ridge structures are observed in correlations of particles associated with and without a jet trigger. We argue that the untriggered ridge arises when particles formed in an early Glasma …

Creg1 And Its Enhancement Of P16ink4a-Induced Senescence, Benchamart Moolmuang

Wayne State University Dissertations

Bypassing cellular senescence, an irreversible growth arrest of cells that is activated in normal cells to become immortal is one of the prerequisites for carcinogenesis. Cellular senescence can be triggered by shortening of telomeres and certain cellular stresses. Using spontaneously immortalized Li-Fraumeni Syndrome (LFS) fibroblasts, we found that CREG1 (Cellular Repressor of E1A-stimulated Genes1) is one of genes whose expression fit the criteria of senescence-associated genes, decreased expression during immortalization and increased in senescence. Moreover, we found that epigenetic mechanisms regulate CREG1 expression in LFS fibroblasts. CREG1 is a secreted glycoprotein that was shown to bind Rb-family pocket proteins and …

Immunomodulatory Effect Of Host And Fungal Eicosanoids During Host-Pathogen Interactions With Candida Albicans, Gitanjali Kundu

Wayne State University Dissertations

Candida albicans, an opportunistic fungal pathogen, poses a significant clinical threat to immunocompromised patients. Diseases associated with this fungus ranges from superficial mucosal infection to life-threatening systemic candidiasis. The mechanisms by which Candida persists at mucosal surfaces in the face of an adaptive response are unclear. Candida produces immunomodulatory oxylipins that cross-react functionally with host eicosanoids, which are considered to play important role in regulating innate and adaptive immune responses. Our objective was to characterize the role of prostaglandins produced by the host and this fungus during host pathogen interactions, both in vitro with dendritic cells (DCs) and macrophages, and …

A Comparison Of Parental Self-Efficacy, Parenting Satisfaction, And Other Factors Between Single Mothers With And Without Children With Developmental Disabilities, Raymond Phillip Small

Wayne State University Dissertations

Depression and stress occur among single mothers and raising a child with a developmental disability can be a difficult burden. The purpose of this study was to determine if having a child with a developmental disability was a source of stress and depression among single mothers, and if this impinged on parental self-efficacy, parenting satisfaction, and social support. The moderating potential of having a child with a disability was examined on relationships between stress, depression, parental self-efficacy, parenting satisfaction, and social support. Understanding these relationships could be useful in the service delivery system to single mothers and families of children …

A Study Of Structure-Property Correlation In V2o5 And Tio2 Based Thin Films As Functional Materials, Chandra Thapa

Wayne State University Dissertations

ABSTRACT

A STUDY OF STRUCTURE-PROPERTY CORRELATION IN V2O5 AND TiO2 BASED THIN FILMS AS FUNCTIONAL MATERIALS

by

CHANDRA THAPA

June 2010

Advisor: Dr. Ratna Naik

Co-Advisor: Dr. K. R. Padmanabhan

Major: Physics (Condensed Matter)

Degree: Doctor of Philosophy

The focus of this thesis is to study the structure-property correlation in thin films of V2O5 and TiO2 based transition metal oxides as functional materials. V2O5 is investigated as a cathode material for lithium ion battery and TiO2 as a high-K dielectric material.

We studied V2O5 thin films prepared by spin coating using three different types of precursors, MOD precursor, sol-gel organic …

The Civic Engagement Of Latino Immigrants In The United States, Cristina Michele Tucker

Wayne State University Dissertations

This study employs acculturation and civic engagement theories to explain the incorporation and engagement of Latino immigrants in American society by examining how demographic characteristics, socioeconomic factors, and characteristics of the immigrant experience, as moderated by acculturation and trust in government influence their civic engagement.

The core component of the study is a secondary data analysis of the 2006 Latino National Survey (Fraga et al., 2008). The study shows that some of the strongest predictors of civic engagement in the Latino immigrant community are citizenship, length of residence in the United States, level of education, household income, age, country of …

Dechalcogenative Allylic Selenosulfide And Disulfide Rearrangements For Cysteine Modification And Glycoligation, Venkataraman Subramanian

Wayne State University Dissertations

This thesis describes investigations directed at the development of methods for the selenosulfide and disulfide rearrangements for the permanent functionalization of thiols, and in particular of cysteine and carbohydrate based thiols. Emphasis is placed on the newly invented silver mediated allylic desulfurative rearrangement for the primary modification of thiols and the synthesis of complex oligosaccharide mimics.

Chapter one introduces the concept of chemoselective ligations for the modification of macromolecules like carbohydrates and proteins. It overviews the native and non-native ligation techniques for their modification of such entities with a attention focusing on thiol based ligation techniques. The later part of …

An Evaluation Of The Effectiveness Of A Diversity Educational Program, Sonya Annette Berkley

Wayne State University Dissertations

ABSTRACT

AN EVALUATION OF THE EFFECTIVENESS OF A DIVERSITY EDUCATIONAL PROGRAM

by

SONYA A. BERKLEY

May 2010

Advisor: Mary Cay Sengstock

Major: Sociology

Degree: Doctor of Philosophy

Administrators and educators have been given the responsibility of working towards improving racial and social interactions in their school settings. It is important to note that most of the literature on diversity programming suggests that the perception held by a school's administration of what constitutes an all encompassing racially and culturally diverse program plays an important role in its implementation and success.

With the continual growth of minority populations in the United States, …

Synergistic Effects Of Garcinol And Gemcitabine In Enhancing Therapeutic Efficacy In Pancreatic Adenocarcinoma Cells And Its Effect On Microrna Profile, Mansi Anand Parasramka

Wayne State University Dissertations

SYNERGISTIC EFFECTS OF GARCINOL AND GEMCITABINE IN ENHANCING THERAPEUTIC EFFICACY IN PANCREATIC ADENOCARCINOMA CELLS AND ITS EFFECT ON MICRORNA PROFILE

By

MANSI PARASRAMKA

ADVISOR: DR. SMITI V. GUPTA

MAJOR: NUTRITION AND FOOD SCIENCE

DEGREE: DOCTOR OF PHILOSPHY

Human Pancreatic Cancer (PaCa) is one of the most hostile and fourth leading cause of cancer deaths in the United States. Current standard chemotherapeutic agent for advanced PaCa is gemcitabine, a cytotoxic nucleoside analogue which results in modest response due to high degree of inherent and acquired chemo resistance. Forthcoming evidence strongly supports that non-nutritive food components have therapeutic benefits attributable to pleiotropic …

Raman Spectroscopic Modeling Of T- Lymphocyte Activation And Detection Of Acute Renal Allograft Rejection, Kristian L. Brown

Wayne State University Dissertations

ABSTRACT

RAMAN SPECTROSCOPIC MODELING OF T-LYMPHOCYTE ACTIVATION AND DETECTION OF ACUTE RENAL ALLOGRAFT REJECTION

By

KRISTIAN L. BROWN

2010

Advisor: Gregory Auner, PhD

Major: Biomedical Engineering

Degree: Doctor of Philosophy

Despite the advances made in the area of kidney transplantation, the disparity between the demand and available donated organs remains a dominant and unresolved issue. Given the paucity of available renal allografts the preservation of existing grafts is vital. One factor that has negatively impacted renal allograft survival is acute rejection (AR). Traditionally, kidney transplant centers have used elevations in serum creatinine as a screening tool for detecting AR. However, …

The Cellular And Genetic Mechanisms Underlying Morphological Diversity Of Insects, Nataliya Turchyn

Wayne State University Dissertations

The vast diversity of insect appendages provides an excellent model for examining the cellular and molecular basis of phenotypic changes in nature. One of the hallmarks of evolution of insect appendages is the differential enlargement of hind (T3) legs compared to their fore (T1) and mid (T2) counterparts. While basic information regarding the genetic mechanisms that regulate the size of the T3 legs became available in the past several years, virtually nothing is known about cellular mechanisms involved. To address this issue, we measured the relative mitotic activity (RMA) in Acheta domesticus (house cricket) and Oncopeltus fasciatus (milkweed bug), two …

The Effect Of Word Sociality On Word Recognition, Sean Seaman

Wayne State University Dissertations

While research into the role of semantic structure in the recognition of written and spoken words has grown, it has not looked specifically at the role of conversational context on the recognition of isolated words. This study was a corpus-based and behavioral exploration of a new semantic variable - sociality - and used on-line behavioral testing to obtain new word recognition data using the visual and auditory lexical decision tasks. The results consistently demonstrated that sociality is one of the most robust predictors of lexical decision performance. Overall, it appears that the visual lexical decision task is quite sensitive to …

Children's Adaptive Psychological Functioning In The Face Of Adversity, Rebecca Wiersma

Wayne State University Dissertations

This explanatory research study is a secondary data analysis of the restricted release version of the National Survey of Child and Adolescent Well-Being (NSCAW) data. Only children from the CPS sample were used and included only children who were 48 months or younger at the time of the initial survey (N=1,582). At the time of the initial survey, only the caregivers of 406 children were able to complete the Child Behavior Checklist (CBCL)/2-3 because of age restrictions for that particular measure. Therefore, a subsample of 406 children with CBCL scores at Wave 1 and Wave 4 was extracted from the …

Beyond The Dvh - Spatial And Biological Radiotherapy Treatment Planning, Bo Zhao

Wayne State University Dissertations

Purpose: Both spatial and biological information are necessary in order to perform true optimization of a treatment plan and for predicting clinical outcome. The goal of this work is to develop an enhanced treatment plan evaluation tool which incorporates biological parameters and retains spatial dose information.

Methods: A software system named SABER (Spatial And Biological Evaluation for Radiotherapy) is developed which provides biological plan evaluation with a novel combination of features. It incorporates hyperradiosensitivity using the induced-repair model and applies the new concept of Dose Convolution Filter (DCF) to simulate dose wash-out …