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Washington University in St. Louis

2010

Ecology

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Genetic And Phenotypic Differentiation Between Winemaking And Wild Strains Of Saccharomyces Cerevisiae, Katie Hyma May 2010

Genetic And Phenotypic Differentiation Between Winemaking And Wild Strains Of Saccharomyces Cerevisiae, Katie Hyma

All Theses and Dissertations (ETDs)

Traditionally, Saccharomyces cerevisiae has been associated with wine, beer and bread production, yet wild strains have also been isolated from natural habitats. While all strains of S. cerevisiae as well as other Saccharomyces species are capable of wine fermentation, a genetically distinct group of S. cerevisiae strains is primarily used to produce wine. These strains exhibit an apparent genetic bottleneck, which led to the hypothesis that wine stains have been domesticated from `wild' natural strains. However, it is unknown whether the genetic bottleneck was accompanied by selection for phenotypic differences. In this study we tested for phenotypes correlated with the …


The Effects Of Habitat Corridors And Edges On Sources Of Seed Mortality: Implications For Restoring A Threatened Legume, Melissa Simon Jan 2010

The Effects Of Habitat Corridors And Edges On Sources Of Seed Mortality: Implications For Restoring A Threatened Legume, Melissa Simon

All Theses and Dissertations (ETDs)

No abstract provided.


Functional Genomic Examinations Of Interactions Between Common Members Of The Human Gut Microbiota, Michael Mahowald Jan 2010

Functional Genomic Examinations Of Interactions Between Common Members Of The Human Gut Microbiota, Michael Mahowald

All Theses and Dissertations (ETDs)

The adult human gut microbiota consists of hundreds to thousands of bacterial species, the majority belonging to the Bacteroidetes and the Firmicutes. Differences in the balance between these phyla has been linked to obesity in mice and humans. However, little is known about their interactions in vivo. I have used comparative and functional genomics, proteomics and biochemical assays to identify the ways they marshal their genomic resources to adapt to life together in the distal gut. I first annotated the complete genome sequences of two human gut Bacteroidetes (Bacteroides vulgatus and Parabacteroides distasonis) and two Firmicutes (Eubacterium rectale and E. …


Inbreeding Depression And Competition In The Square-Stemmed Monkey-Flower (Mimulus Ringens), Nicholas Griffin Jan 2010

Inbreeding Depression And Competition In The Square-Stemmed Monkey-Flower (Mimulus Ringens), Nicholas Griffin

All Theses and Dissertations (ETDs)

Matings between biologically related individuals often produce offspring with reduced fitness, a phenomenon known as inbreeding depression. The magnitude of inbreeding depression can play an important role in determining the overall fitness, and persistence, of populations, and is often considered one of the key factors driving the evolution of mating systems and their associated traits. Recent research has shown that the strength of inbreeding depression is often highly sensitive to environmental conditions, such as the availability of abiotic resources or variation in the strengths of ecological interactions between organisms. In plant populations, drought, plant density, herbivory, and infection by pathogens, …