Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 6 of 6
Full-Text Articles in Entire DC Network
A Marginal Returns Theory Of Politics, Carlos Costa
A Marginal Returns Theory Of Politics, Carlos Costa
All Theses and Dissertations (ETDs)
A great deal of contemporary social science rests on a basic, ``primitive'', principle that rational agents are motivated by a quest for marginal returns to investment of time, money, and other resources. In this manuscript we argue that an analogue fundamental principle guides much of modern political science, but has remained largely This manuscript sets out to unearth, reshape and polish this principle into what we term a marginal return theory of politics. We then apply this theory to the study of electioneering in Latin America, focusing on two main elements of vote seeking: the returns of specific votes and …
Development Of Thymic Natural Killer Cells From Double Negative 1 Thymocyte Precursors, Claudia Vargas
Development Of Thymic Natural Killer Cells From Double Negative 1 Thymocyte Precursors, Claudia Vargas
All Theses and Dissertations (ETDs)
While there has been much progress in defining the specificity and function of natural killer: NK) cells, their differentiation has not been fully elucidated. Previous studies of thymocyte development in vitro indicate that double negative: CD4&minusCD8&minus, DN) thymocytes can develop into cells with NK cell markers, but these cells have not been well characterized. Moreover, a subpopulation of NK cells which requires an intact thymus, i.e, thymic NK cells, has been described with selective expression of CD127 although their origin and differentiation are also poorly understood. Herein, we generated and characterized NK cells differentiating from thymic DN precursors. We enriched …
Suprachiasmatic Nuclei Development: A Characterization Of Transcription Factors And The Influence Of Retinal Innervation And Vip Signaling, Cassandra Vandunk
Suprachiasmatic Nuclei Development: A Characterization Of Transcription Factors And The Influence Of Retinal Innervation And Vip Signaling, Cassandra Vandunk
All Theses and Dissertations (ETDs)
The suprachiasmatic nuclei: SCN) are highly specialized neural structures with an essential behavioral function; creating the rhythm of the mammalian central clock and entraining that internal clock to the external world. The nuclei each consist of approximately 10,000 neurons, each capable of creating near 24 h rhythms, organized into a highly structured network. While the molecular clockwork underlying the rhythm within neurons and network properties have been well studied, how the nuclei are initially specified and how the network develops is poorly understood. Herein, we seek to elucidate the genes and mechanisms involved in the specification and development of SCN …
Mechanics Of Heart Tube Formation In The Early Chick Embryo, Victor Varner
Mechanics Of Heart Tube Formation In The Early Chick Embryo, Victor Varner
All Theses and Dissertations (ETDs)
The heart is the first functioning organ to form in the embryo. For decades, biologists have worked to identify many of the genetic and molecular factors involved in heart development, and over the years, these efforts have helped elucidate the vast biochemical signaling networks, which drive cardiac specification and differentiation in the embryo. Still, the biophysical mechanisms which link these molecular factors to actual, physical changes in cardiac morphology remain unclear. The aim of this thesis is to identify some of the mechanical forces which drive heart tube assembly in the early chick embryo. A unique feature of this work …
The Brains Of Babies: A Surface Based Approach To Study Cortical Development In Term And Preterm Human Infants, Jason Hill
All Theses and Dissertations (ETDs)
Half a million infants are born before term gestation each year in the United States. Although advances in newborn medicine have increased survival rates of very preterm infants to almost 90%, surviving preterm infants are at increased risk for developing lasting neurologic impairments. In order to develop a plausible neuroprotective strategy it is imperative that we improve our understanding of normal cortical development and develop tools to evaluate injury. Using a surface based approach we have characterized normal cortical development in healthy term infants and analyzed abnormalities associated with preterm birth. Accurate cortical surface reconstructions for each hemisphere of 12 …
'If We Govern Ourselves, Whose Son Is To Govern Us?': Youth, Independence And The 1960s In Lesotho, John Aerni-Flessner
'If We Govern Ourselves, Whose Son Is To Govern Us?': Youth, Independence And The 1960s In Lesotho, John Aerni-Flessner
All Theses and Dissertations (ETDs)
Young people in Lesotho worked actively to bring about their own conceptions of the nation in late colonial and early independence Lesotho. These youth drew on a wide range of local, national and international ideas to push for institutional change that would benefit themselves as individuals, and the nation as a whole. Tapping into larger global debates about development, the Cold War and the role of youth in societies, young Basotho actively participated in and wanted a say in the changes coming with independence. This work rethinks African nationalism, seeing a wider range of people willing and able to identify …