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Dact Family Molecules In Wnt Signaling In Mouse Development, Daniel Fisher
Dact Family Molecules In Wnt Signaling In Mouse Development, Daniel Fisher
All Theses and Dissertations (ETDs)
The Wnt: Wingless-Integration) molecular signaling pathways are known to be integral in the embryonic patterning of multicellular animals, and are misregulated in multiple types of cancer. Wnt signaling includes multiple biochemical signaling pathways downstream of the Wnt family of secreted proteins and their receptors. Many, and possibly all, of these pathways converge on the intracellular protein Dishevelled, whose interactions appear essential in determining the cell-autonomous effects of the Wnt signal. Dact: Dapper, Antagonist of Beta Catenin Targeting) proteins were identified based on their binding to Dishevelled. There are three Dact encoding genes in mammals, and these show unique expression patterns …
Opium And Insurgency: Development And Decay In Southern Afghanistan, Adam Ebrahim
Opium And Insurgency: Development And Decay In Southern Afghanistan, Adam Ebrahim
All Theses and Dissertations (ETDs)
No abstract provided.
Mechanisms Of Copper Deficiency In The Zebrafish Embryo, Erik Madsen
Mechanisms Of Copper Deficiency In The Zebrafish Embryo, Erik Madsen
All Theses and Dissertations (ETDs)
Proper maternal nutrition is critical for early embryonic development. Despite overwhelming epidemiologic data indicating the benefits nutrient supplementation for the developing organism we do not fully understand the genetics of predisposition to abnormal developmental phenotypes when faced with suboptimal nutrient levels. Copper is an essential nutrient required for critical biochemical processes. Severe defects in copper homeostasis lead to significant disease typified by the X-linked recessive disorder Menkes disease. Patients with Menkes disease have cutis laxa, bone deformities, hypopigmentation, arterial malformation, and neurodegeneration due to copper deficiency caused by loss-of-function mutations in ATP7A, a copper transport protein. Despite the critical requirement …