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Investigations Into Building Block Structure And Method Of Preparation On The Properties Of Nanomaterials, Zicheng Li
Investigations Into Building Block Structure And Method Of Preparation On The Properties Of Nanomaterials, Zicheng Li
All Theses and Dissertations (ETDs)
This dissertation research is primarily focused on the preparation of polymer-based nanostructures as potential diagnostic agents and therapeutics delivery vehicles. Various polymers, nanoparticles and conjugation techniques were developed to meet the specific requirements of each application. Shell crosslinked nanoparticles: SCKs) are characterized by their structural integrity and available functionality to attach multiple agents on the shell, such as receptor-recognizing or receptor-specific ligands, .imaging agents, Cell transduction components, etc. In this work, SCKs derived from amphiphilic poly(acrylic acid)-block-polystyrene: PAA-b-PS) have been studied as potential diagnostic and therapeutic agent delivery vehicles: Chapters 2 and 4). SCK nanoparticles bearing a cyclic KCRGDC peptide …
Developing New Methodologies For Crosslinked Polymeric Nanostructure Syntheses, Chemoselective Modifications, And Applications As Imaging And Delivery Agents, Guorong Sun
All Theses and Dissertations (ETDs)
The overall emphasis of this dissertation research includes the syntheses of amphiphilic block copolymers bearing functional groups through controlled radical polymerization techniques, followed by the aqueous assembly of these block copolymer precursors to construct polymeric nanostructures with different sizes and morphologies. Further chemical modification of the nanostructures afforded functional crosslinked nano-objects with reporting probes for imaging and biocompatible "stealth" materials for tuning the in vivo fate of nanostructures. Amphiphilic block copolymers poly(acrylic acid)-block-polystyrene: PAA-b-PS) with well-defined structures were prepared through nitroxide-mediated radical polymerization: NMP). Using novel pre-functionalization strategies, these block copolymer precursors were functionalized with DOTA for chelating 64Cu and …
Improving Biocompatibility By Controlling Protein Adsorption: Modification And Design Of Biomaterials Using Poly(Ethylene Glycol) Microgels And Microspheres, Evan Scott
All Theses and Dissertations (ETDs)
Guided by the clinical needs of patients and developments in biology and materials science, the primary focus of the biomaterials field remains at the solid/liquid interface between biomaterial surfaces and biological fluids. For blood-contacting devices, biological responses are initially elicited and directed by proteins that adsorb from this multicomponent solution to form thin films on their surfaces. The identity, conformation, and quantity of adsorbed proteins are related to the properties of a material's surface. For example, hydrophobic surfaces tend to be thrombotic via interactions between platelets and adsorbed fibrinogen, while surface-activation of specific enzymes initiates the coagulation cascade on hydrophilic …
Development Of Shell-Crosslinked Knedel-Like Nanoparticles As Intracellular Delivery Vehicles And Gene Regulation Agents, Ke Zhang
All Theses and Dissertations (ETDs)
This dissertation focuses on the development of polymer-based nanomaterials, termed shell-crosslinked knedel-like: SCK) nanoparticles, as vehicles to carry specific guest molecules or guest structures into the cell. Detailed synthetic procedures for and characterization of well-defined block copolymers, as well as the nanostructures resulted from their self-assembly are reported. The nanoparticles exhibited different but controlled sizes and shapes, depending on the conditions for their preparation. To incorporate functionality into these materials, both pre- and post-particle functionalization methods, as well as their combination, were used. The nanostructures involved in this dissertation include protein transduction domain: PTD)-functionalized SCK, folate-functionalized SCK and cationic SCK: …