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Integrated Genomics Of Susceptiblity To Therapy-Related Leukemia, Patrick Cahan
Integrated Genomics Of Susceptiblity To Therapy-Related Leukemia, Patrick Cahan
All Theses and Dissertations (ETDs)
Therapy-related acute myeloid leukemia t-AML is a secondary, generally incurable, malignancy attributable to the chemotherapeutic treatment of an initial disease. Although there is a genetic component to susceptibility to therapy-related leukemias in mice, little is understood either about the contributing loci, or the mechanisms by which susceptibility factors mediate their effect. An improved understanding of susceptibility factors and the biological processes in which they act may lead to the development of t-AML prevention strategies. In this thesis work, we identified expression networks that are associated with t-AML susceptibility in mice. These networks are robust in that they emerge from distinct …
Batf Regulates Previously Unknown Ap-1 Target Genes To Control Th17 Differentiation, Barbara Schraml
Batf Regulates Previously Unknown Ap-1 Target Genes To Control Th17 Differentiation, Barbara Schraml
All Theses and Dissertations (ETDs)
Activator protein 1: AP-1) transcription factors are dimers of Jun, Fos, musculoaponeurotic fibrosarcoma: MAF) and activating transcription factor: ATF) family proteins that are characterized by a basic region and a leucine zipper domain. While many AP-1 proteins also contain defined transcriptional activation domains: TADs), some consist only of a basic region and leucine zipper and are thought to function as inhibitors of AP-1 activity. We found that the AP-1 protein Batf, which lacks a TAD, is highly expressed in T helper cells compared to various other immune cells and tissues. IL-17-producing T helper: TH17) cells are a CD4+ T cell …
Taking The Edge Off: The Role Of Stressful Events And Perceived Stress On Alcohol Use And Problems Among Older Adults, Paul Sacco
All Theses and Dissertations (ETDs)
Alcohol misuse by older adults is a significant public health concern and is projected to worsen with the aging of the "baby boom" generation. To help understand the nature of older adult alcoholism, it is crucial to investigate factors such as stress that may influence consumption and problem use among older adults. Findings are mixed on the role of stress and coping in alcohol use, and studies comparing the role of stress and coping in alcohol use on different age groups are rare. Therefore, this study had the following aims: 1) To test a stress and coping model of current …
Systemic Levels Of G-Csf And Il-6 Determine The Angiogenic Potential Of Bone Marrow Resident Monocytes, Alyssa Gregory
Systemic Levels Of G-Csf And Il-6 Determine The Angiogenic Potential Of Bone Marrow Resident Monocytes, Alyssa Gregory
All Theses and Dissertations (ETDs)
Recent studies have demonstrated the efficacy of hematopoietic cell-based therapies in promoting therapeutic angiogenesis for a wide variety of vascular syndromes, however the cell populations responsible and the mechanisms involved are poorly understood. Using a mouse model of hindlimb ischemia, we previously showed that an adoptive transfer of donor monocytes significantly enhanced revascularization. Monocytes are a widely heterogeneous cell population and differences in the ability of various monocyte subsets to mediate revascularization have not been previously investigated. Using the hindlimb ischemia model we demonstrate that an adoptive transfer of inflammatory: CX3CR loGr-1+), but not resident: CX3CR1hiGr-1-) monocytes, significantly enhances revascularization …
Coordinate Interstitial Deletions Of Retinoblastoma (Rb1) And Neurobeachin (Nbea) Genes On Chromosome 13 In Mgus And Multiple Myeloma, Julie O'Neal
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ABSTRACT OF THE DISSERTATION Coordinate interstitial deletions of Retinoblastoma: RB1) and Neurobeachin: NBEA) genes on chromosome 13 in monoclonal gammopathy of undetermined significance: MGUS) and multiple myeloma By Julie O'Neal Doctor of Philosophy in Biology and Biomedical Sciences: Molecular and Cellular Biology) Washington University in Saint Louis, 2009 Assistant Professor Michael H. Tomasson, Chair Numeric or structural chromosomal abnormalities are detected in nearly all patients with plasma cell dyscrasias, including primary amyloidosis, monoclonal gammopathy of undetermined significance: MGUS) and multiple myeloma: MM). Chromosome 13 deletions, most frequently monosomy 13, are detected in 10- 20% of MM cases by routine cytogenetics …
The Effect Of Limb Movement On The Lumbopelvic Region In People With Low Back Pain, Sara Scholtes
The Effect Of Limb Movement On The Lumbopelvic Region In People With Low Back Pain, Sara Scholtes
All Theses and Dissertations (ETDs)
Low back pain: LBP) affects up to 80% of the population at some point in their lifetime. Several models have been proposed to explain the persistent and recurrent course of LBP. In particular, the Movement System Impairment model proposes that lumbopelvic motion that begins soon after the start of an active movement is important to LBP because of its potential contribution to increased frequency of lumbopelvic motion across the day. The purpose of this dissertation is to examine aspects of this model, focusing specifically on lumbopelvic motion during limb movements. In Chapter 2, we examine whether men and women with …