Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Entire DC Network
Beyond The Observable: Examining Self-Reported Well-Being In People With Dementia, Wingyun Mak
Beyond The Observable: Examining Self-Reported Well-Being In People With Dementia, Wingyun Mak
All Theses and Dissertations (ETDs)
The well-being of people with dementia is not well understood. Researchers often measure their well-being through observational methods or via proxies, but self-report is rarely used. Recently there is evidence that people with mild to moderate dementia are able to give reliable reports of their well-being, but empirical work in this area is limited. Most dementia-specific measures focus on mood or life satisfaction, and there are few that gauge more existential aspects of well-being: e.g., purpose in life). This study tested the use of a non-dementia-specific well-being measure in people with mild to moderate dementia. The relationship between goal pursuit, …
Temporal Discounting: A Comparison Of Adjusting-Amount And Adjusting-Delay Procedures, Daniel Holt
Temporal Discounting: A Comparison Of Adjusting-Amount And Adjusting-Delay Procedures, Daniel Holt
All Theses and Dissertations (ETDs)
Several experimental procedures: e.g., adjusting amount, adjusting delay) have been used to study the effect that changes in amount of and delay to a reward have on the reward's subjective value. The present series of three experiments sought to test the implicit assumption that the underlying decision-making process: discounting) is identical regardless of the procedure used, and that all would converge on similar indifference points. For each of the experiments, participants were initially tested on one of the adjusting tasks: Adjusting Immediate Amount, Adjusting Delayed Amount, or Adjusting Delay) and returned a week later to complete each of the remaining …
Computational And Experimental Investigation Of Allosteric Communication In The Transcriptional Regulator Nikr, Michael Bradley
Computational And Experimental Investigation Of Allosteric Communication In The Transcriptional Regulator Nikr, Michael Bradley
All Theses and Dissertations (ETDs)
The Ni2+ and DNA binding protein NikR is involved in nickel regulation in Escherichia coli through transcriptional repression of the NikABCDE nickel permease. NikR is a homotetramer and each chain contains both a DNA binding ribbon-helix-helix: RHH) domain and a Ni2+ binding regulatory ACT: aspartokinase, chorismate mutase, TyrA) fold. Work herein combines computational modeling of NikR structure with experimental studies aimed at understanding allosteric communication between the ACT and RHH domains. Hydrogen/deuterium exchange mass spectrometry shows a Ni2+ specific NikR conformational change relative to bound Cu2+, Co2+, and Zn2+. Concurrent coordination geometry and in vivo repressor function studies show that …
Discounting Of Delayed And Probabilistic Rewards By Women With And Without Binge Eating Disorder, Jamie Manwaring
Discounting Of Delayed And Probabilistic Rewards By Women With And Without Binge Eating Disorder, Jamie Manwaring
All Theses and Dissertations (ETDs)
Obese individuals with binge eating disorder: BED) exhibit more general and eating-disordered psychopathology than obese individuals without BED. Binge eating also impedes weight-loss efforts, already difficult in an obese population. A better basic understanding of binge eating and obesity is needed to refine treatments for both conditions. Discounting, an experimental paradigm that examines changes in the value of delayed or uncertain outcomes, may provide an objective assessment of impulsive behavior. Impulsivity may perpetuate binge eating, but discounting tasks have never been evaluated with eating disordered individuals. A discounting procedure could help differentiate individuals with eating/weight problems from controls in terms …