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Washington University in St. Louis

Arts & Sciences Electronic Theses and Dissertations

Theses/Dissertations

2019

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Affective Misattribution Following Memory Decisions Does Not Transfer To Interleaved Items, David Grybinas Dec 2019

Affective Misattribution Following Memory Decisions Does Not Transfer To Interleaved Items, David Grybinas

Arts & Sciences Electronic Theses and Dissertations

The outcomes of memory search appear to have affective consequences. For instance, during recognition memory tests, concluding that a retrieval probe is from a prior study period (‘old’) leads to higher pleasantness ratings for the probe than concluding it is novel (‘new”). Grybinas, Kantner, and Dobbins (2019) explained this and related findings via a Confirmation of Search (COS) hypothesis that assumes that the affective consequences of successful versus failed episodic retrieval are misattributed to probes used to elicit memory search. While these affective misattributions clearly occur for the memory probes themselves (within-item misattribution), social psychological research has previously shown that …

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Accuracy Matters For The Benefits Of Sleep After Retrieval Practice, Steven Dessenberger Dec 2019

Accuracy Matters For The Benefits Of Sleep After Retrieval Practice, Steven Dessenberger

Arts & Sciences Electronic Theses and Dissertations

Previous research suggests that while sleep and retrieval practice can each improve memory on their own, their benefits cannot be combined to produce an additive effect unless feedback is given during the initial test. These previous findings would seem to support a retrieval-as-consolidation of the testing effect, which states that the benefits of retrieval are the result of memory consolidation, a process that normally occurs during the sleep cycle. The present study sought to determine whether the retrieval-as-consolidation account held true when initial test accuracy was considered as a factor. Using foreign language word pairs, we examined the combined effects …

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Fear Of Positive Evaluation And Negative Affect From Inclusion In Cyberball, Jason Ted Grossman Dec 2019

Fear Of Positive Evaluation And Negative Affect From Inclusion In Cyberball, Jason Ted Grossman

Arts & Sciences Electronic Theses and Dissertations

Fear of positive evaluation (FPE) is a construct related to social anxiety that involves discomfort when receiving positive attention and feedback from others. FPE research has increased over the past decade, and results suggest that it may be an important part of social anxiety for some individuals; however, it is not yet known whether FPE may also include discomfort from being included in social situations. Level of inclusion was hypothesized to moderate the relationship between FPE and negative affect from being over included such that those with high FPE would feel more uncomfortable the more they were included. To test …

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Children's Perceptions Of Status At The Intersection Of Race And Gender, Grace Reid Dec 2019

Children's Perceptions Of Status At The Intersection Of Race And Gender, Grace Reid

Arts & Sciences Electronic Theses and Dissertations

By 6 years of age, children associate males with higher status than females (Liben, Bigler & Krogh, 2001), and Whites with higher status than Blacks (Bigler, Averhart & Liben, 2003). However, little is known about how race and gender interact to influence children’s thinking about status. In Study 1, we asked whether children associate White men with higher status than other races and genders. Sixty children selected from among Black and White male and female targets the person who they thought would do familiar and novel jobs that varied in status. White men were the most likely to be chosen …

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Investigating Biological Mechanisms Of Radiation Resistance In Advanced Stage Cervical Cancer, Fiona Ruiz Dec 2019

Investigating Biological Mechanisms Of Radiation Resistance In Advanced Stage Cervical Cancer, Fiona Ruiz

Arts & Sciences Electronic Theses and Dissertations

The current standard of care treatment for locally advanced cervical cancer is curative intent pelvic radiation with concurrently administered platinum chemotherapy (CRT). This treatment strategy is effective for many patients, but 33-50% of patients treated with CRT develop disease recurrence. Metastatic and recurrent cervical cancer is an incurable condition, and many of the currently available treatments are associated with significant morbidity and mortality. Identifying these patients upfront is a challenge that clinicians face when developing treatment strategies. Previous studies used to catalog the genomic and transcriptomic landscape of cervical cancer lacked high quality corresponding clinical follow up data for patients, …

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Young Children’S Knowledge About The Role Of Print In Reading, Molly Farry-Thorn Dec 2019

Young Children’S Knowledge About The Role Of Print In Reading, Molly Farry-Thorn

Arts & Sciences Electronic Theses and Dissertations

Children begin to learn about the print in books and the role it plays in reading well before the onset of formal literacy instruction. Young children’s knowledge about precisely what readers are reading when they read books and who is able to read books has been studied primarily through interviews, but conclusions from this research are limited by methodological concerns. Three experiments examined whether pre-readers understand what part of a book is read and whether they distinguish between the skill of reading and the activity of reading. Although pre-readers were typically able to locate the print in a book, they …

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Instrumentation For Dynamic Nuclear Polarization And Application Of Electron Decoupling For Electron Relaxation Measurement, Nicholas Howard Alaniva Dec 2019

Instrumentation For Dynamic Nuclear Polarization And Application Of Electron Decoupling For Electron Relaxation Measurement, Nicholas Howard Alaniva

Arts & Sciences Electronic Theses and Dissertations

Dynamic nuclear polarization nuclear magnetic resonance (DNP NMR) exploits internal electron spin and nuclear spin interactions to increase sensitivity and uncover valuable information regarding structure and dynamics of a system. To manipulate these interactions, instrumentation is developed to combine high-power microwave and radiofrequency irradiation with the ability to spin samples at the magic angle (MAS) at temperatures from 90 K to 4.2 K. Electron decoupling uses frequency-modulated microwaves to mitigate the electron-nuclear dipolar interaction, improving signal intensity and resolution in DNP NMR experiments. Electron decoupling is combined with short DNP periods to encode electron spin information in polarized nuclear signal. …

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Development And Application Of Mass Spectrometry-Based Protein Footprinting In Structural Proteomics, Ming Cheng Dec 2019

Development And Application Of Mass Spectrometry-Based Protein Footprinting In Structural Proteomics, Ming Cheng

Arts & Sciences Electronic Theses and Dissertations

Integral mass spectrometry (MS) has emerged as an important tool for protein structural characterization. It readouts are a broad range of structural information, including stoichiometry, interactions, conformations and conformation change, and dynamics. Protein footprinting is a pivotal component in the intergral MS toolkit.My dissertation centers around the development and application of protein footprinting to characterize protein structure. It is divided into seven chapters.Chapter 1 serves as the introduction for integral mass spectrometry in structural proteomic.In Chapter 2, we extended the fast-photochemical oxidation of proteins (FPOP) platform by adding the trifluoromethyl radical (•CF3) as a new reagent. We discovered that •CF3 …

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Transcriptional Regulation Of Adipose Tissue Development By Pexrap And Med19, John Dean Dec 2019

Transcriptional Regulation Of Adipose Tissue Development By Pexrap And Med19, John Dean

Arts & Sciences Electronic Theses and Dissertations

Targeting adipose tissue function to decrease adiposity and improve insulin sensitivity could treat obesity and diabetes. How the nuclear receptor PPARγ regulates the development of two functionally distinct types of adipose tissue, brown and white fat (BAT and WAT), as well as the browning of white fat, remains unclear. Our previous studies suggest that PexRAP, a peroxisomal lipid synthetic enzyme, regulates PPARγ signaling and white adipogenesis.Here, we show that PexRAP is an inhibitor of brown adipocyte gene expression. PexRAP inactivation promoted adipocyte browning, increased energy expenditure, and decreased adiposity. Identification of PexRAP-interacting proteins suggests that PexRAP function extends beyond its …

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Sideromycin Pathway Elucidation: Insights Into Salmycin Biosynthesis, Transport Paradigms, And Drug Release, Gerry Sann Macaraeg Rivera Dec 2019

Sideromycin Pathway Elucidation: Insights Into Salmycin Biosynthesis, Transport Paradigms, And Drug Release, Gerry Sann Macaraeg Rivera

Arts & Sciences Electronic Theses and Dissertations

Antibiotic resistance is an increasing threat in today’s society. In order to overcome resistant bacteria, it is necessary to discover new drugs with novel mechanisms of action. This work focuses on the sideromycin pathway, encompassing the biosynthetic production, mechanism of entry and hydrolysis-mediated drug release. Sideromycins are an interesting approach to combat the rise of antibiotic resistance since they provide a different avenue that overcomes problems that arise when entering the cell. The dissertation is separated into distinct sections dealing with the various areas of interest in the sideromycin pathway, particularly for the sideromycin, salmycin, produced by Streptomyces violaceus. The …

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Devising A Scalable Synthesis To Probe The G-Protein Cell Receptor Signaling Pathway, Matthew Robert Medcalf Dec 2019

Devising A Scalable Synthesis To Probe The G-Protein Cell Receptor Signaling Pathway, Matthew Robert Medcalf

Arts & Sciences Electronic Theses and Dissertations

The G-protein coupled cell receptor signaling pathway is amongst the largest and most diverse class of cell-surface receptors in the body. Nearly 800 different genes encode for these cell membrane receptors which are responsible for mediating a variety of hormones, neurotransmitters, and sensory stimuli through the activation of intracellular G proteins. To date, roughly 34% of pharmaceuticals on the market target GPCR’s, but despite this fact, there are still many difficulties associated with targeting this family of receptors. The vast number of GPCR’s, disease states resulting from a dysregulation of multiple GPCR signaling pathways, and difficulties crystalizing and purifying the …

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An Evolving Epigenome That Determines Tissue And Cell Specificity, Renee Louise Sears Dec 2019

An Evolving Epigenome That Determines Tissue And Cell Specificity, Renee Louise Sears

Arts & Sciences Electronic Theses and Dissertations

Understanding the mechanisms driving phenotypic variation is a major goal of biology that unifies classical genetics with the emerging fields of genomics and epigenomics. Human and mouse share over 90% of genes and global tissue-specific patterns of expression are maintained between the species. Thus, it is hypothesized that gene expression is influenced through distinctive regulation among species in order to account for the unmistakable phenotypic divergence. DNA methylation, histone modifications, open chromatin patterns, transcription factor binding, and other epigenetic factors are all associated with shaping, maintaining, and repressing regulatory regions which in turn coordinate gene expression. It is vital to …

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The Tortured Pre-History Of Urban Blight: African American St. Louis And The Politics Of Public Health, 1877-1940, Taylor Desloge Dec 2019

The Tortured Pre-History Of Urban Blight: African American St. Louis And The Politics Of Public Health, 1877-1940, Taylor Desloge

Arts & Sciences Electronic Theses and Dissertations

This dissertation is a long history of the contested legal and environmental category of blight, especially in its racialized dimensions, in tandem with the African American experience of living in blighted urban spaces and forging a black politics of public health and welfare. Rethinking the conventional view that identifies blight as simply a preoccupation of post-World War II planners, this dissertation relocates its roots in a politics of public health that emerged a hundred years earlier, in the Post-Reconstruction Era, when black migration to the city and the rise of industrial capitalism raised new questions over both the social needs …

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Generation And Utilization Of Diverse Memory B Cells After Flavivirus Challenges, Rachel Wong Dec 2019

Generation And Utilization Of Diverse Memory B Cells After Flavivirus Challenges, Rachel Wong

Arts & Sciences Electronic Theses and Dissertations

Over the course of an effective immune response to an infection, two distinct B cell populations are generated to provide protection against reinfection, long-lived plasma cells (LLPCs) and memory B cells (MBCs). LLPCs and MBCs originate from germinal center (GC) B cells that have undergone B cell receptor (BCR) affinity maturation through iterative rounds of somatic hypermutation, proliferation, and selection. Thus, LLPCs and MBCs can bind to their antigen with higher affinity than their naïve B cell precursors. LLPCs constitutively secrete antibodies and can provide sterilizing immunity that pre-exists subsequent infections. MBCs, on the other hand, are quiescent and provide …

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Physiologic And Pathologic Profiling Of Clonal Variations, Wing Hing Wong Dec 2019

Physiologic And Pathologic Profiling Of Clonal Variations, Wing Hing Wong

Arts & Sciences Electronic Theses and Dissertations

This thesis sought to provide a better understanding of clonality in various malignant and non-malignant settings using a variety of genomic analytical tools. Clonality is pre-defined as the presence of a mixed population of cells in which each sub-population has distinct somatic mutation profile. It is a common feature in cancers where subpopulations of cells arise as a result of independent, yet continual acquisition of somatic mutations. The clonal architecture of cancers can be used as a diagnostic and prognostic biomarker as well as to monitor disease progression or resolution. Besides cancer, clonal variability and expansion is also implicated in …

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Genomic Contributors To Individual Differences In Reward-Related Neural Activity, Lindsay Jane Michalski Dec 2019

Genomic Contributors To Individual Differences In Reward-Related Neural Activity, Lindsay Jane Michalski

Arts & Sciences Electronic Theses and Dissertations

Aberrant reward-related behavior, including impulsive and risk-taking behaviors, is a common feature of externalizing psychopathology (e.g., attention deficit hyperactivity disorder, antisocial personality disorder, and substance-use disorders). Through imaging studies, these behaviors have been linked to dysregulated reactivity within a diffuse reward-related corticostriatal neural network, including the striatum, frontal regions (namely orbital, ventromedial, and dorsolateral cortices), the insula, and the hippocampus. Because variability in risk-taking behavior and related psychopathology is moderately-to-largely heritable (i.e., with estimates ranging from 40 – 80%), a genetically-informed approach is well-positioned to provide valuable insight into the etiology of reward-related neural and behavioral phenotypes that characterize externalizing …

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Elucidating Enhancer Function In Epidermal Development And Filaggrin Loss-Of-Function Variants In African American Atopic Dermatitis, Mary Elizabeth Mathyer Dec 2019

Elucidating Enhancer Function In Epidermal Development And Filaggrin Loss-Of-Function Variants In African American Atopic Dermatitis, Mary Elizabeth Mathyer

Arts & Sciences Electronic Theses and Dissertations

The epidermis is the outermost tissue of the skin and provides the body’s first line of defense against external assaults. The epidermis is primarily composed of keratinocytes that terminally differentiate and rise apically toward the surface to form the semipermeable barrier of the skin. A hallmark of keratinocyte terminal differentiation is the expression of genes from the Epidermal Differentiation Complex (EDC) locus. Many of the EDC protein products contribute to the structural integrity of the skin barrier, evidenced by several gene knockouts such as loricrin, and even genetic variation within gene coding sequences, that modulate the integrity of the skin …

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Crip Time In Fin-De-Siècle Spain: Disability, Degeneration, And Eugenics, Erika Rodriguez Dec 2019

Crip Time In Fin-De-Siècle Spain: Disability, Degeneration, And Eugenics, Erika Rodriguez

Arts & Sciences Electronic Theses and Dissertations

A period of intense nation-building, the late nineteenth century was marked by the search for medical and legal solutions to the increasing number of bodies that did not align with culturally constructed expectations of productivity and reproduction in Spanish modernity. Authors of this time used representations of disability to engage in urgent political questions about population control and the rights of individuals in the face of increasing medical intervention. In carrying out this analysis, I raise the question of how representations of disability created a space to reconfigure the social values that determined what lives matter. Focusing on canonical realist …

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A Noncanonical Function Of The Telomerase Rna Component In Human Embryonic Stem Cells, Kirsten Ann Brenner Dec 2019

A Noncanonical Function Of The Telomerase Rna Component In Human Embryonic Stem Cells, Kirsten Ann Brenner

Arts & Sciences Electronic Theses and Dissertations

Telomeres are stretches of TTAGGG nucleotide repeats located at the ends of linear chromosomes that shorten with progressive cell division and prevent genomic instability at the cost of limiting a cell’s capacity to proliferate. This limitation can be overcome by telomerase, a ribonucleoprotein complex that elongates telomeres via reverse-transcription of the template telomerase RNA component (TERC). Recent studies have reported potential functions of TERC outside of its role in telomere maintenance. These noncanonical functions of TERC are however poorly defined, and the molecular mechanisms and biological relevance behind such functions remain elusive. Here, we generated conditional TERC knock-out human embryonic …

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Activation And Regulation Of The Alkbh3-Ascc Alkylation Repair Pathway, Josh Brickner Dec 2019

Activation And Regulation Of The Alkbh3-Ascc Alkylation Repair Pathway, Josh Brickner

Arts & Sciences Electronic Theses and Dissertations

DNA repair is essential to prevent the cytotoxic or mutagenic effects of various types of DNA lesions. These lesions are sensed by distinct pathways to recruit repair factors specific to type of damage. In particular, the ALKBH family of proteins recognizes and repairs specific alkylated lesions, including 1-methyladenine (m1A) and 3-methylcytosine (m3C). A major outstanding question in the field is how the AlkB homologue ALKBH3 and its associated protein partners are recruited to sites of alkylation damage and how this repair activity is regulated. Understanding the upstream signaling events that mediate recognition and repair of DNA alkylation damage is particularly …

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Wheelchair Propulsion For Everyday Manual Wheelchair Users: Repetition Training And Machine Learning-Based Monitoring, Pin-Wei Chen Dec 2019

Wheelchair Propulsion For Everyday Manual Wheelchair Users: Repetition Training And Machine Learning-Based Monitoring, Pin-Wei Chen

Arts & Sciences Electronic Theses and Dissertations

Upper limb pain and injuries are prevalent among manual wheelchair users and can restrict their participation and daily activities. Due to the high repetition and force in wheelchair propulsion, chronic wheelchair propulsion has been linked to the risk of upper limb pain and injury. Prevention of upper limb pain and injury is a high priority in wheelchair-related research. Decades of research in wheelchair propulsion biomechanics have led to clinical practice guidelines (CPG). Unfortunately, a decade after the publication of the CPG, CPG-recommended propulsion is still uncommon. Hence, for the first aim, a randomized controlled trial pilot study with two groups …

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T Cell Immunity In Pancreatic Cancer Is Undermined By Dendritic Cell Dysfunction, Samarth Hegde Dec 2019

T Cell Immunity In Pancreatic Cancer Is Undermined By Dendritic Cell Dysfunction, Samarth Hegde

Arts & Sciences Electronic Theses and Dissertations

Pancreatic cancer carries a dismal prognosis, and desperately needs viable therapeutic interventions beyond chemo-radiation. T cell-dependent immunotherapies have shown great promise in several tumor types, but have not been effective for the vast majority of pancreatic cancer patients. This is, in part, due to our limited understanding of how antigenicity of pancreatic lesions is recognized, and how adaptive immunity is overcome in this disease. We sought to study tumor-immune interactions and identify mechanisms for this immune-failure using several spontaneous and unperturbed mouse models of pancreatic adenocarcinoma. We found that early pancreatic lesions fail to elicit tumor-limiting CD4+ TH1 and CD8+ …

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The Transcription Factor Bhlhe40 Regulates Tissue-Resident Macrophages And Type 2 Immunity, Nicholas N. Jarjour Dec 2019

The Transcription Factor Bhlhe40 Regulates Tissue-Resident Macrophages And Type 2 Immunity, Nicholas N. Jarjour

Arts & Sciences Electronic Theses and Dissertations

Transcriptional control of gene expression is essential for life, tailoring protein production to development and environment to maintain organismal homeostasis. A limited set of proteins termed transcription factors are critical to this process. As our understanding of these central regulators has improved, new aspects of cell and organismal biology have been revealed. Herein, we demonstrate the importance of the transcription factor Bhlhe40 to tissue-resident macrophages, T helper type 2 cells, and type 2 immune responses, revealing novel transcriptional control of macrophages and unexpected cytokine regulation of helminth infection. We find that Bhlhe40 is cell-intrinsically required for normal proliferation of large …

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Perceptual Precedence Or Increased Effort?: On The Mechanism Of The Small-Picture-Size Advantage In Category Learning, Toshiya Miyatsu Dec 2019

Perceptual Precedence Or Increased Effort?: On The Mechanism Of The Small-Picture-Size Advantage In Category Learning, Toshiya Miyatsu

Arts & Sciences Electronic Theses and Dissertations

I have previously identified a novel perceptual manipulation that enhances learning of some complex natural categories, and the current dissertation aims to uncover its mechanism. Specifically, learning of categories of tropical fish was enhanced when learned through small pictures (about 2º) compared to large pictures (about 19º). Through analyzing the previous results and extant theories in various domains, I identified two potential mechanisms through which this small-picture-size advantage manifested. The perceptual precedence hypothesis postulates that the processing of local dimensions is prioritized in large pictures and the processing of global dimensions is prioritized in small pictures. Therefore, small picture size …

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Phylogenetic And Genomic Characterization Of The Host-Pathogen Arms Race Between Bacterial Pathogens And Gossypium Hirsutum, Anne Zimmerman Phillips Dec 2019

Phylogenetic And Genomic Characterization Of The Host-Pathogen Arms Race Between Bacterial Pathogens And Gossypium Hirsutum, Anne Zimmerman Phillips

Arts & Sciences Electronic Theses and Dissertations

Hosts and pathogens are eternally intertwined in an evolutionary arms race. When a pathogen causes a disease outbreak, scientists must identify resistance strategies that can durably tilt the arms race in favor of the host. This requires a deep understanding of both the genetic and environmental contexts in which the outbreak occurs. In this thesis I investigate the bacterial pathogens Xanthomonas citri pv. malvacearum (Xcm) and Pseudomonas syringae that caused disease outbreaks on Gossypium hirsutum from 2011-2017. I use pathogen genomics and host transcriptomics to develop hypotheses for how these pathogens emerged and how they cause disease. Phylogenetics and virulence …

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Cyclotron Resonance In Graphene Heterostructurescyclotron Resonance In Graphene Heterostructures, Billy Jordan Russell Dec 2019

Cyclotron Resonance In Graphene Heterostructurescyclotron Resonance In Graphene Heterostructures, Billy Jordan Russell

Arts & Sciences Electronic Theses and Dissertations

We present observations of cyclotron resonance in graphene Van der Waals heterostructure devices. Such devices provide dramatic improvements in sample quality and allow for ad- vanced electronic control, opening windows on previously inaccessible physics. The design and construction of a dedicated system for the measurement of electronic transport and infrared magnetospectroscopy in microscopic samples of atomically thin materials at cryogenic temperatures is presented. In high-mobility encapsulated monolayer graphene, electron- electron interaction effects are unambiguously observed to impact the interband cyclotron resonance as the Landau level filling factor is varied in a quantizing magnetic field. Additionally, a splitting of transitions involving …

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The Biomedical Application Of Chimeric Antigen Receptor T Cell Therapy, Jessica Devenport Dec 2019

The Biomedical Application Of Chimeric Antigen Receptor T Cell Therapy, Jessica Devenport

Arts & Sciences Electronic Theses and Dissertations

No abstract provided.

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Investigating The Relationship Between Gaze Behavior And Audiovisual Benefit Across Various Speech-To-Noise Ratios, Lauren Gaunt Dec 2019

Investigating The Relationship Between Gaze Behavior And Audiovisual Benefit Across Various Speech-To-Noise Ratios, Lauren Gaunt

Arts & Sciences Electronic Theses and Dissertations

Speech perception improves when listeners are able to see as well as hear a talker, compared to listening alone. This phenomenon is commonly referred to as audiovisual (AV) benefit (Sommers et al., 2005). According to the Principle of Inverse Effectiveness (PoIE), the benefit of multimodal (e.g. audiovisual) input should increase as unimodal (e.g. auditory-only) stimulus clarity decreases. However, recent findings contradict the PoIE, indicating that it should be reassessed. One method for investigating the factors that contribute to AV speech benefit is to examine listeners’ gaze behavior with eye tracking. The present study compared young adults’ (N=50) gaze …

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Finding And Analyzing De Novo Mutations In The Exomes Of Parent-Offspring Trios Of Spontaneous Chiari Malformation Type 1 Patients, Brian Leon Ricardo Dec 2019

Finding And Analyzing De Novo Mutations In The Exomes Of Parent-Offspring Trios Of Spontaneous Chiari Malformation Type 1 Patients, Brian Leon Ricardo

Arts & Sciences Electronic Theses and Dissertations

Chiari Malformation Type 1 (CM1) is a neurodevelopmental disorder that occurs when one of the cerebellar tonsils herniates past the foramen magnum causing headaches, motor or sensory deficits, sleep apnea, and difficulty swallowing. This disorder is estimated to affect 1% of the population but due to the need of neuroimaging for diagnosis and the presence of asymptomatic patients there is still uncertainty about the exact proportion of the population affected. CM1 often presents itself with other neurodevelopmental disorders such as syringomyelia, scoliosis, and known genetic syndromes such as Klippel-Feil and Marfan syndromes. Twin, family, and familial clustering studies have established …

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Neuroticism And Stressful Life Events: Probing Mechanisms Underlying Vulnerability To Stress-Related Depression, Erin Bondy Dec 2019

Neuroticism And Stressful Life Events: Probing Mechanisms Underlying Vulnerability To Stress-Related Depression, Erin Bondy

Arts & Sciences Electronic Theses and Dissertations

Elevated neuroticism (N) potentiates the depressogenic effects of stressful life events (SLEs). We first replicate this association using longitudinal data (N=971 older adults) from the St. Louis Personality and Aging Network (SPAN) study. Here, SLEs prospectively predicted future depressive symptoms, especially among those reporting elevated N, even after accounting for prior depressive symptoms and previous SLE exposure (NxSLE interaction: p=0.016, ΔR2=0.003). These findings were further replicated in cross-sectional analyses of the Duke Neurogenetics Study (DNS), a young adult college sample with neuroimaging data (n=1,343: NxSLE interaction: p=0.019, ΔR2=0.003). Because evidence suggests that stress may promote depression …

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