Digital Commons Network^™

Utilizing Ai Integrated Neuroimaging Technology To Expand Upon Machine Learning In Positron Emission Tomography Technology With The Aim Of Detecting Amyloid Beta Biomarkers Early In The Onset Of Alzheimer's., Ethan S. Terman

Undergraduate Research Posters

Early intervention in Alzheimer's is vital for treatment. The earlier a professional can detect symptoms and make a diagnosis the earlier a prognosis can be implemented. With the prevalence of data in our day-to-day world combined with Artificial intelligence (AI), utilizing both for machine learning can pave the way for more accurate and efficient detection of Alzheimer's and other neurodegenerative diseases. AI combined with Machine learning (ML) increases diagnostic efficiency and reduces human errors, making it a valuable resource for physicians and clinicians alike. With the increasing amount of data processing and image interpretation required, the ability to use AI …

Parasocial Relationships In Variety Live Streaming: How It Can Affect Attitudes And Buying Intention Toward Sponsors, Megan Burroughs, Deborah Diazgranados

Undergraduate Research Posters

Online streaming and video platforms have become a popular form of entertainment as opposed to traditional media like movies and TV shows. Similar to traditional media, viewers often relate to and form one-sided relationships with actors/creators, known as parasocial relationships. Actors and creators can then leverage that relationship to advertise and market products to their audience. The primary objective of this study was to understand if perceived credibility and loyalty towards a streamer fuel parasocial relationships and how perceived credibility and parasocial relationships with an online live streamer influence attitude towards a sponsored brand and purchasing intention. It was predicted …

Keep It Simple? Effects Of Color And Age On Product Packaging, Saamiya R. Mohammed, Alex Robinson

Undergraduate Research Posters

Packaging has always played a pivotal role in consumer decision-making. Specifically, the color of the visual elements placed on product packaging have garnered significant attention for their potential to influence consumer perceptions and behaviors. Color is believed to have emotional/psychological associations across cultural and societal contexts.

On the one hand, research has noted that the use of grayscale does not elicit an emotional response (Clarke and Costall, 2008) and this may be because they’re considered passive colors (Bottomley and Doyle, 2006). Conversely, Jacobs et. al (1991), found that black is associated with being expensive and powerful. Based on the conflicting …

Lycosidae Abundance And Diversity Across Lawn And Leaf Litter Substrate, Sage O. Lockett, Dan Albrecht-Mallinger

Undergraduate Research Posters

Significant knowledge gaps exist in how land-cover impacts ground-hunting spider populations. To fill these gaps, this study investigates a common family of ground-hunting spiders, Lycosidae, to determine differences in their abundance and diversity in deciduous leaf litter and managed turfgrass (lawn). The study was conducted within a forested ecosystem at Virginia Commonwealth University's Rice Rivers Center in Charles City County, Virginia. I placed 10 belt transects (1m x 20m) on lawn substrate and 10 identical transects in deciduous forest leaf litter substrate. I performed repeated visual census via eyeshine and manual capture of up to three individuals per transect …

How Does A Global Climate Cycle Affect The Reproductive Output Of A Neotropical Migratory Bird?, Abby K. Bressette, Emma Cummings, Daniel Albrecht-Mallinger, Lesley Bulluck

Undergraduate Research Posters

El-Niño Southern Oscillation (ENSO) causes regional changes in climate and has been found to have varying effects on the survival, fecundity, and recruitment of migratory songbirds. This study seeks to better understand the effect of ENSO on the fecundity of Virginia-breeding Prothonotary warbler (Protonotaria citrea; PROW), a neotropical migratory songbird. PROW breed in the Eastern United States and spend the non-breeding season primarily in Panama and Colombia. Ongoing research in Virginia has found a positive relationship between spring precipitation and predicted number of PROW fledgelings during La Niña, but the opposite during El Niño. To better understand this relationship, we …

Carry-Over Effects Of Climate On Prothonotary Warbler (Protonotaria Citrea) Feather Quality, Alyssa N. Spasic, Dan Albrecht-Mallinger, Lesley Bulluck

Undergraduate Research Posters

Avian species have inspired numerous studies on ornamentation, exploring its role in intra- and intersexual selection as a marker for individual quality. Male birds have been the focus of most of these studies while females, which can also display ornamentation, have been studied less. Coloration achieved through molt, particularly carotenoid-based pigments, requires energy derived from food resources. As climate affects insect abundance, there may be a link between climate conditions during molt and feather quality the following season. We assessed the relationship between temperature and precipitation during molt and female Prothonotary Warbler (Protonotaria citrea) breast and crown feather reflectance metrics …

Qualitative Study Of Hiv-Related Stigma In The Dental Care Setting, Sania A. Pullen, Dr. Dina T. Garcia

Undergraduate Research Posters

Objectives: People living with HIV (PLWH) are susceptible to developing a variety of oral conditions that if left untreated can lead to sore gums, painful chewing, and tooth loss as well as compromise HIV management and viral suppression. Despite the increased risk of developing oral conditions, it is estimated that up to 58% of PLH do not receive regular dental care. This study aimed to examine HIV-related stigma and discrimination in the dental care setting.

Methods: Adults living with HIV who receive care through the Ryan White HIV/AIDS Program at the VCU Infectious Disease (ID) clinic were recruited to participate. …

A Comparison Of Three Dna Extraction Methods On 45-Year-Old Pupae Cases, Ananya Udyaver, Casey Flint, Jeffery Tomberlin, Baneshwar Singh

Undergraduate Research Posters

Blow flies are the primary colonizers of human cadavers. In many death investigations, insect evidence can help in prediction of minimum post-mortem interval (PMImin) but to do that, the first step is to identify collected insect evidence. For immature stages, morphological keys are either limited or incomplete and hence DNA based identification is used. For DNA based ID, DNA extraction is the first and the most important step, especially when collected evidence is highly degraded. The main aim of this study was to compare three DNA extraction methods (QIAgen Blood and Tissue Kit, organic, and QIAgen DNA Investigator Kit) to …

The Role Of The Nlrp3 Inflammasome In Alzheimer's Disease, Ethan S. Terman

Undergraduate Research Posters

This study examines the consequences of Alzheimer’s in rat and mice test subjects. The goal is to identify the effects of certain NLRP3 inhibiting drugs and to see if there are any noticeable effects in regards to impeding the pathological development of Alzheimer’s disease. The results are visualized by implementing the immunohistochemical process to identify neurodegeneration in the brain and to assess the expression levels of amyloid beta as an indicator of Alzheimer’s pathology. Other tests are also conducted on these transgenic mice to gauge cognitive functioning levels during the onset of their disease, those being behavior tests, but not …

Ros And Sfk Signaling Is Required For Development Of Hematopoietic Stem Cells In Zebrafish, Bradley Williams, Erich Damm

Undergraduate Research Posters

ROS and SFK signaling is required for development of hematopoietic stem cells in zebrafish

Bradley Williams and Erich Damm

Background

Hematopoiesis is the process in which the myriad of mature blood cell types, including erythrocytes and leukocytes, develop from hematopoietic stem cells (HSCs) throughout the life of an organism. In vertebrates, HSCs originate from endothelial cells lining the floor of the dorsal aorta. This process is referred to as the endothelial to hematopoietic transition and is likely controlled in part by molecular signals from neighboring cells. Investigation into the molecular signaling mechanisms controlling the development of HSCs is critical to …

The Impact Of The Covid-19 Pandemic On Mental Health Of College Students, Alexis West, Afton White, Punit Gandhi, Indranil Sahoo, Michael Robert, David Chan

Undergraduate Research Posters

In April and May of 2020, at the beginning of the pandemic, a few hundred VCU students were surveyed about their academics, mental health, support network, and the impact COVID was having in their life.

Glyphosate And Dopaminergic Neurotoxicity: Herbicide Impacts On Parkinson's Disease Development, Lojy Hozyen

Undergraduate Research Posters

Nearly one million individuals in the United States are living with Parkinson’s disease (PD). In the past two decades, the death rate from PD has risen by about 63 percent in the United States. Major findings have been made in the past five years about the potential impact of glyphosate (N-(phosphonomethyl) glycine) exposure on the onset of PD symptoms. The purpose of this meta-analysis is to provide a compiled update on the chemical and biological alterations that glyphosate imposes on the human brain. A meta-analysis was conducted to create a quantitative estimate of the connection between PD and glyphosate. Findings …

Testing The Efficacy And Synergistic Components Of Sesamol And Black Rice Extract On Human Colon Cancer Cells, Sera Lim, Philip M. Gerk

Undergraduate Research Posters

Purpose: Systemic treatment of colorectal cancer involves chemotherapeutic agents which elicit serious and negative side effects from the toxicity of the drug. To address this issue, we are testing dietary supplements for their efficacy against human colon cancer cell lines and also their potential synergistic effects when combined with conventional chemotherapy. Dietary supplements (specifically sesamol and black rice extract) exhibit anticancer, anti-inflammatory, and chemo-preventive properties. Meanwhile, one of the cancer resistance mechanisms is the upregulation of drug elimination mechanisms, leading to multi-drug resistance. We hypothesize that dietary compounds will act as chemo-enhancers, thus enhancing potency of the chemotherapy drug(s) on …

Strong Homotopy Lie Algebras And Hypergraphs, Samuel J. Bevins, Marco Aldi

Undergraduate Research Posters

We study hypergraphs by attaching a nilpotent strong homotopy Lie algebra. We especially focus on hypergraph theoretic information that is encoded in the cohomology of the resulting strong homotopy Lie algebra.

The Association Between Survivors’ Guilt And Gratitude In The Belongingness Of Refugee College Students, Mehwish Safdar

Undergraduate Research Posters

Many refugees experience significant stress and trauma before relocating to their host country (Leo, 2021) and often encounter new challenges when adapting to their unfamiliar environment. Refugee college students, who are often the first in their families to attend college, face additional pressure to excel academically to give back to their families and host country (Turjanmaa & Jasinskaja-Lahti, 2020). Despite prior research on refugee individuals, little work has focused on refugee college students. This study aimed to address this gap by examining the relationships between survivors’ guilt, gratitude, indebtedness, and belongingness in 16 refugee university students. Specifically, the study investigated …

Covid-19 Impact On Latinx Families Within The Rva Breathes Program, Abigail Poulston, Robin S. Everhart, Ph.D, Sarah C M Morton

Undergraduate Research Posters

RVA Breathes is a community-based asthma intervention program that aims to reduce asthma disparities among 5 to 11-year-old children in Richmond, Virginia. Prior to the pandemic, Latinx children faced greater disparities in asthma treatment and morbidity than non-Latinx White children. During the pandemic, there is evidence to suggest that these disparities may have been further exacerbated. Specifically, research shows that COVID-19 health disparities among Latinx individuals arose due to social inequities, such as poverty, living conditions, lack of access to health care, language barriers, and employment. The current study provides an overview of responses from 20 Latinx caregivers to pandemic-related …

Memory Reconsolidation And Alcohol Use Disorder: Intravenous Infusion Of Ketamine To Alleviate Addictive Symptoms In Alcohol Use Disorder Diagnoses, Yasaswi Veera

Undergraduate Research Posters

According to the National Institute of Health, substance use disorder in the United States in 2021 caused nearly 106,000 deaths and an annual healthcare and criminal justice expenditure of roughly $200 billion, however, only 10% of diagnoses receive proper treatment. This is primarily due to the lack of previous research in addictive studies as well as the lack of accessibility to resources and proper treatments. Current treatments for alcohol use disorder range from medications and behavioral therapies, such as acamprosate, naltrexone, and cognitive behavior therapy. Much of these treatments consist of reconditioning the brain to associate alcohol with a negative …

Investigation Of The Dyrk1a Regulation By Lzts2-Sipa1l1 Complex, Rebecca Gunnin, Austin Witt B.S., Larisa Litovchick M.D.,Ph.D.

Undergraduate Research Posters

A region on chromosome 21, the Down Syndrome critical region (DSCR), is associated with major defects found in Down Syndrome, such as craniofacial malformations. DYRK1A is a gene found on chromosome 21 within the DSCR that encodes an enzyme, dual specificity tyrosine-phosphorylation-regulated kinase 1A. DYRK1A is known to phosphorylate many substrate proteins and is thought to be involved in tumor suppression, neurological development, cell cycle regulation, and aging. Recently, the Litovchick lab and others reported that DYRK1A also plays a role in the double-strand break repair of DNA, which could lead to mutations and tumorigenesis, if deregulated.

The Litovchick lab …

The Collaboration Between Art And Botany, Hee So, Sierra Beecher

Undergraduate Research Posters

Using past research from my work study with Dr. Beecher where a team of students focused on quantitative and diagnostic anatomies of salt marsh and beach grasses on the Atlantic coasts, I used the research collected and created vector-based diagrams that were easily readable for Biology students at VCU. These illustrations were used in a manuscript we have been preparing, which has been accepted by the “Castanea” scientific journal. During the research fellowship, I was able to design a poster that portrayed the benefits of collaboration between art and botany, and Dr. Beecher presented the poster at the ASPB conference …

Black Liberation In Transnational Terms: The Case Of Haiti And The United States, Dulanda F. P. Saintcyr

Undergraduate Research Posters

Haiti made history on January 1st, 1804 when it secured independence from France. Not only did Haiti become a sovereign state, it also earned the title of being the first independent Black nation in the world. The latter accomplishment should not be ignored. The Haitians’ efforts created an impact that transcends their national border, particularly in the context of Black liberation. For example, the United States' history of working towards achieving full freedom for Black people resembles the Haitian struggle. Whether the connection between the two states is widely acknowledged is a point of interest. As a result, this project …

Analysis Of Fiber Uv Degradation Through An Environmental Chamber, Davis A. Eames

Undergraduate Research Posters

Environmentally degraded fibers could impact multiple aspects of a fiber comparison, considering that collected weathered fabrics/fibers may express an altered chemical structure and/or colorimetric property compared to their unexposed counterparts. Depending on the amount of degradation the evidence has suffered, it could be challenging for forensic scientists to make conclusions from their comparative analyses. Observations presented in this study were orchestrated to test the possible outcomes that sunlight has on fabric-based materials. Photodegradation of fabrics was investigated through the use of an environmental chamber for a duration of six weeks, which would be equivalent to three months of real-world UV …

Comparing The Microbiomes Of Dental Plaques In 19th Century Ancestral Remains, Ananya Udyaver

Undergraduate Research Posters

During the construction of VCU’s Hermes A. Kontos Medical Sciences Building in April 1994, nineteenth century ancestral remains were found in an abandoned well on the Medical College of Virginia (MCV) campus. This well, now known as the East Marshall Street Well (EMSW), is thought to have been used as a disposal location for cadaver dissection for surgical and other medical waste in the past. VCU is now seeking to use DNA sequencing technology to match and assemble bones from each individual for a proper burial, uncover the cultural and historical context in which these people lived, and bring a …

Structural Analysis Of Predicted Proteins Using Alphafold, Brydon P. Wall

Undergraduate Research Posters

The function of around 67% of predicted proteins from genes in Mycobacteriophage CheetoDust can not be confidently predicted using traditional techniques and can only be functionally labeled “hypothetical proteins”. However, a new approach using AlphaFold, an artificial intelligence tool to generate a structural prediction from a sequence, can take advantage of structurally conserved regions that were previously obfuscated to gain new insights and visualize data in new ways.

Since amino acid sequences are more conserved than its corresponding DNA sequence, amino acid sequences are used when predicting the function of the corresponding translated protein. Until recently, predicting structure from an …

Prevalence Of Nicotine Delivery Systems By Biological Sex In The Spit For Science Study, Ayrton Quiroz, Amy Adkins, S4s Working Group, Elizabeth Prom-Wormley, Elizabeth K. Do, Megan Cooke, James Clifford, Hermine H. Maes

Undergraduate Research Posters

Nicotine intake usage trends have changed over recent decades given the wide variety of nicotine delivery systems including cigarettes, vaping, hookah, and snubs/chewables. These trends also vary by demographic factors, such as race/ethnicity, sex, and socioeconomic status (SES). For example, studies in rat populations, as well as humans, have found that females tend to be more dependent on nicotine products and have a more difficult time quitting than male rats and humans (Pogun et al., 2017). Also, race/ethnicity may impact the frequency of nicotine usage in different populations; in that non-white Hispanics were more susceptible to smoking through adolescence with …

Racial Experiences And Racial Identity Experiences Of “New” African Americans In The United States, Sosna Marshet, Kenna Yadeta

Undergraduate Research Posters

The challenges faced by Black immigrants in the United States are significant, beginning with isolation and loneliness and intensified by pervasive discrimination. This study examines the impact of racism on the racial identity of Black immigrants in the United States. Using the Multidimensional Inventory of Black Identity (MIBI), various dimensions of Black identity were measured among 119 Black first and second-generation immigrants aged 18 to 51. The results showed a positive correlation between experiences of racism and the centrality dimension of Black identity, a negative correlation with the humanist, and a positive correlation with Nationalist dimensions of Black identity. These …

Cellular Glycosphingolipid Imbalance Modulates Emt In Cancer Cells, Laura E. Clark, Amanda Dickinson, Santiago Lima

Undergraduate Research Posters

Sphingolipids are key components of the plasma membrane and are regulators of complex biological processes often altered in cancer cells. In human tumors, genes of key enzymes that regulate levels of glucosylceramide and lactosylceramide are often amplified. However, it is unknown why these traits are positively selected in transformed cells. In this work, we used CRISPR-Cas9 to knockout two key enzymes amplified in tumors in HeLa and H1703 tumor-derived cell-lines. As expected, the knockout lines had dramatic accumulation of GlcCer and LacCer. However, unexpectedly, they showed significantly decreased in-vitro wound-healing capacity and an almost complete loss of in-vitro extra-cellular matrix …

Development And Usability Testing Of A Phr For Down’S Syndrome (Ds) Care Coordination, Edward Ladia, Brianna Boston, Bethany Cosgrove Phd, Elizabeth Baker Phd, Jeffrey Duah

Undergraduate Research Posters

321Connect was first drafted by Dr. Bethany Cosgrove to support caregivers of children with Down’s Syndrome in coordinating care.

These children often require multiple appointments with various healthcare professionals throughout the course of their life. Caregivers expressed a need for accurate and up-to-date information, providing evidence of the potential benefit of an mHealth application. A mobile health application with a PHR (personal health record) for the child would aid in keeping track of this information. However, there is no existing solution on the market that met this need, prompting the creation of 321Connect.

321Connect aims to provide information and support …

A Three-Dimensional In Vitro Model Of Disease That Improves Preclinical Research By Incorporating Genetic Diversity And Increasing Physiological Accuracy, Akash Jagdeesh

Undergraduate Research Posters

Biomedical research is essential for the discovery of new medications and treatments, and is built upon the cooperation of preclinical (in vitro/vivo) research and clinical trials. However, 85% of treatments previously successful in vitro/vivo fail in clinical trials, suggesting that in vitro models are poor indicators of clinical success. The issue lies in conventional “two-dimensional” in vitro models containing genetically identical cells grown on a flat plate, which lack the variety of cell types and cooperation/structure found in real tissue. Moreover, 2D in vitro models do not simulate humans’ genotypic variability, which affects both …

Patient-Specific Analysis Of Aortic Hemodynamics And Wall Shear Stresses In Patients Undergoing Pediatric Bariatric Surgery Using 2d Phase-Contrast Mri, Oluwaferanmi S. Akande, Joao Soares, Nathan Hargan, Dr. Uyen Truong, Haeung Kang, David Lanning

Undergraduate Research Posters

Patient-Specific Analysis of Aortic Hemodynamics and Wall Shear Stresses in Patients Undergoing Pediatric Bariatric Surgery using 2D Phase-Contrast MRI

Feranmi Akande¹ Nathan Hargan² Haesung Kang³ David Lanning³ Uyen Truong⁴ João S. Soares¹

¹ Department of Biomedical Engineering, College of Engineering, Virginia Commonwealth University

² Department of Mechanical & Nuclear Engineering, College of Engineering, Virginia Commonwealth University

³ Department of Cardiology, Children’s Hospital of Richmond, Virginia Commonwealth University

Introduction: Severe obesity among today’s youth is a rising epidemic within the United States. Emerging research has linked childhood obesity with shortened life expectancy and early …

Finite Element Analysis Of 3d-Printed Pcl Scaffolds, Ireolu K. Orenuga, Joao Soares, Phillip D. Glass, Daeha Joung Ph.D.

Undergraduate Research Posters

Finite Element Analysis of 3D-printed PCL Scaffolds for Synergizing Cellular Micro-Environment and Mechanical Stimuli to Enhance Engineered Tissue Growth in Vitro

Ireolu Orenuga,1 Phillip Glass,2 Daeha Joung,2 Joao S. Soares1

1. Department of Mechanical and Nuclear Engineering, College of Engineering, Virginia Commonwealth University
2. Department of Physics, College of Humanities & Sciences, Virginia Commonwealth University

Introduction: Tissue engineering aims to create viable and functional engineered tissues via biodegradable scaffolds and autologous cells. Scaffolds play an essential part in organizing the architecture of developing tissues and aid in the proper function of implants acutely by serving as mechanical support and long-term by …