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Pharmacokinetics Of Ceftibuten-Cis And Its Trans Metabolite In Healthy Volunteers And In Patients With Chronic Renal Insufficiency, Judy Shepard Kelloway, Walid M. Awni, Chin C. Lin, Josephine Lim, Melton B. Affrime, William F. Keane, Gary R. Matzke, Charles E. Halstenson
Pharmacokinetics Of Ceftibuten-Cis And Its Trans Metabolite In Healthy Volunteers And In Patients With Chronic Renal Insufficiency, Judy Shepard Kelloway, Walid M. Awni, Chin C. Lin, Josephine Lim, Melton B. Affrime, William F. Keane, Gary R. Matzke, Charles E. Halstenson
Pharmacotherapy and Outcomes Science Publications
The impact of renal insufficiency on the dispositions of 300 mg of orally administered ceftibuten-cis, a new broad-spectrum oral cephalosporin, and its primary metabolite ceftibuten-trans was characterized in 30 adult subjects. Subjects were divided into five groups of six subjects each on the basis of their 24-h ambulatory creatinine clearances (CLCR). The apparent total body clearance (CLP/F; where F is absolute bioavailability) and renal clearance of ceftibuten-cis were significantly lower in subjects with end-stage renal disease (on maintenance hemodialysis; group V) and in those with severe (CLCR, 5 …