Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Entire DC Network
Efficacy And Cost Effectiveness Of Adjuvant Chemotherapy In Women With Node-Negative Breast Cancer — A Decision-Analysis Model, Bruce E. Hillner , M.D., Thomas J. Smith , M.D.
Efficacy And Cost Effectiveness Of Adjuvant Chemotherapy In Women With Node-Negative Breast Cancer — A Decision-Analysis Model, Bruce E. Hillner , M.D., Thomas J. Smith , M.D.
Massey Comprehensive Cancer Center Publications
Abstract
BACKGROUND.
In 1988 the National Cancer Institute issued a Clinical Alert that has been widely interpreted as recommending that all women with node-negative breast cancer receive adjuvant chemotherapy. Acceptance of this recommendation is controversial, since many women who would not have a recurrence would be treated.
METHODS.
Using a decision-analysis model, we studied the cost effectiveness of chemotherapy in cohorts of 45-year-old and 60-year-old women with node-negative breast cancer by calculating life expectancy as adjusted for quality of life. The analysis evaluated different scenarios of the benefit of therapy: improved disease-free survival for five years, with a lesser effect …