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Articles 1 - 30 of 87
Full-Text Articles in Entire DC Network
Xenograft Tumors Vascularized With Murine Blood Vessels May Overestimate The Effect Of Anti-Tumor Drugs: A Pilot Study, Zhihong Dong, Atsushi Imai, Sudha Krishnamurthy, Zhaocheng Zhang, Benjamin David Zeitlin, Jacques E. Nör
Xenograft Tumors Vascularized With Murine Blood Vessels May Overestimate The Effect Of Anti-Tumor Drugs: A Pilot Study, Zhihong Dong, Atsushi Imai, Sudha Krishnamurthy, Zhaocheng Zhang, Benjamin David Zeitlin, Jacques E. Nör
All Dugoni School of Dentistry Faculty Articles
Recent evidence demonstrated that endothelial cells initiate signaling events that enhance tumor cell survival, proliferation, invasion, and tumor recurrence. Under this new paradigm for cellular crosstalk within the tumor microenvironment, the origin of endothelial cells and tumor cells may have a direct impact on the pathobiology of cancer. The purpose of this pilot study was to evaluate the effect of endothelial cell species (i.e. murine or human) on xenograft tumor growth and response to therapy. Tumor xenografts vascularized either with human or with murine microvascular endothelial cells were engineered, side-by-side, subcutaneously in the dorsum of immunodefficient mice. When tumors reached …
Novel And Predominant Pathogen Responsible For The Enterovirus-Associated Encephalitis In Eastern China, Lei Zhang, Jie Yan, David M. Ojcius, Huakun Lv, Ziping Miao, Yin Chen, Yanjun Zhang, Jvying Yan
Novel And Predominant Pathogen Responsible For The Enterovirus-Associated Encephalitis In Eastern China, Lei Zhang, Jie Yan, David M. Ojcius, Huakun Lv, Ziping Miao, Yin Chen, Yanjun Zhang, Jvying Yan
All Dugoni School of Dentistry Faculty Articles
Enteroviruses (EV) have been increasingly identified as the causative agent for unknown etiological encephalitis in many parts of the world, but the long period surveillance for enterovirus-associated encephalitis (EAE) was not reported in China. From 2002-2012 in Zhejiang, Coxsackieviruses A9, B1, B2, B3, B4, B5; and echoviruses 3, 4, 6, 9, 14, 25, 30 were detected from the unknown etiological encephalitis cases, with coxsackievirus B4 been identified here for the first time. From 2002-2004 and 2010-2012, echovirus 30 was found to be the periodically predominant serotype for in the EAE. The molecular typing results showed that all the EV isolates …
Piperazinylpyrimidine Analogues As Protein Kinase Inhibitors, Wade A. Russu, Hassan M. Shallal
Piperazinylpyrimidine Analogues As Protein Kinase Inhibitors, Wade A. Russu, Hassan M. Shallal
Pacific Patents
The invention provides novel compounds based on piperazinylpyrimidine derivatives to be used as protein kinase inhibitors. The compounds may be useful in treating or preventing different cellular proliferation disorders, such as cancer. The present invention also provides methods of preparing these compounds, and methods of using the same.
Kenneth Labarre, Director; Hank Neuberger, Producer. Lady Antebellum: Own The Night World Tour (Dvd). Eagle Rock Entertainment, 2012 (124 Minutes, Ntsc). Www.Eagle-Rock.Com, Keith Hatschek
Conservatory of Music Faculty Articles
No abstract provided.
Rj Smith. The One: The Life And Music Of James Brown. New York: Gotham Books (Penguin Group), 2012. Www.Us.Penguingroup.Com, Keith Hatschek
Rj Smith. The One: The Life And Music Of James Brown. New York: Gotham Books (Penguin Group), 2012. Www.Us.Penguingroup.Com, Keith Hatschek
Conservatory of Music Faculty Articles
No abstract provided.
The Gating Charge Should Not Be Estimated By Fitting A Two-State Model To A Q-V Curve, Francisco Bezanilla, Carlos A. Villalba-Galea
The Gating Charge Should Not Be Estimated By Fitting A Two-State Model To A Q-V Curve, Francisco Bezanilla, Carlos A. Villalba-Galea
School of Pharmacy Faculty Articles
The voltage dependence of charges in voltage-sensitive proteins, typically displayed as charge versus voltage (Q-V) curves, is often quantified by fitting it to a simple two-state Boltzmann function. This procedure overlooks the fact that the fitted parameters, including the total charge, may be incorrect if the charge is moving in multiple steps. We present here the derivation of a general formulation for Q-V curves from multistate sequential models, including the case of infinite number of states. We demonstrate that the commonly used method to estimate the charge per molecule using a simple Boltzmann fit is not only inadequate, but in …
Physics Trick - Balanced Can, Said Shakerin
Physics Trick - Balanced Can, Said Shakerin
All Faculty Articles - School of Engineering and Computer Science
The ordinary 12-oz beverage cans in the figures below are not held up with any props or glue. The bottom of such cans is stepped at its circumference for better stacking. When this kind of can is tilted, as shown in Fig. 1, the outside corners of the step touch the surface beneath, providing an effective contact about 1 cm wide. Because the contact is relatively wide and the geometry is symmetrical, it is easy to balance an empty can by simply adding an appropriate amount of water so that the overall center of mass is located directly above the …
Systems And Methods For Detecting Molecular Interactions Using Magnetic Beads, Joshua P. Steimel, Charles E. Sing, Alfredo Alexander-Katz
Systems And Methods For Detecting Molecular Interactions Using Magnetic Beads, Joshua P. Steimel, Charles E. Sing, Alfredo Alexander-Katz
Pacific Patents
Systems and methods are provided for detecting or measuring binding affinity between different compositions. The methods include contacting one or more magnetic beads having a surface including a first composition with a substrate having a surface including a second composition; applying a rotating magnetic field to the one or more magnetic beads effective to cause the one or more magnetic beads to move across the surface of the substrate; measuring the movement of the one or more magnetic beads across the substrate surface to determine a translational velocity; and determining a binding affinity between the first and second compositions from …
Dynkin Diagrams And Fusion Algebras, Christopher D. Goff
Dynkin Diagrams And Fusion Algebras, Christopher D. Goff
College of the Pacific Faculty Presentations
No abstract provided.
Working Better Together: Library, Publisher, And Vendor Perspectives, M. Collins, Mary M. Somerville, N. Pelsinsky, A. Wood
Working Better Together: Library, Publisher, And Vendor Perspectives, M. Collins, Mary M. Somerville, N. Pelsinsky, A. Wood
University Libraries Librarian and Staff Presentations
In the rapidly evolving scholarly ecosystem, ‘working better together’ is increasingly important. This session will explore how collaborations between libraries, publishers, and vendors can produce new efficiencies in workflows for library staff and lasting improvements to discoverability for academic researchers. Cross-sector representatives will share sector perspectives and discuss interoperability issues, with a common focus on publisher content, research tools, and library systems.
Panelists’ introductory remarks will explore interoperability issues and implementation implications. To set the stage for cross-sector discussion, Maria Collins (NCSU, Head, Acquisitions and Discovery) will describe NCSU’s technical services reorganization and highlight vendor collaborations. Within this framework, panelists’ …
Tracking Retention And Graduation Rates For Transfer Students, Glen Rogers, Kathleen Schwan Minik
Tracking Retention And Graduation Rates For Transfer Students, Glen Rogers, Kathleen Schwan Minik
Academic Affairs Faculty and Staff Presentations
No abstract provided.
Minimizing Part D Costs For Medicare Beneficiaries: Not Just A Drop In The Bucket, Rajul A. Patel, Kate M. O'Dell, Kim-Anh Vo, Tiffany Chu, Kenneth Wang, Shu Lu, Joseph A. Woelfel, Sian M. Carr-Lopez, Suzanne M. Galal, Berit Gundersen
Minimizing Part D Costs For Medicare Beneficiaries: Not Just A Drop In The Bucket, Rajul A. Patel, Kate M. O'Dell, Kim-Anh Vo, Tiffany Chu, Kenneth Wang, Shu Lu, Joseph A. Woelfel, Sian M. Carr-Lopez, Suzanne M. Galal, Berit Gundersen
School of Pharmacy Faculty Presentations
Background: Although Medicare Part D has been largely successful in providing prescription drug coverage for Medicare beneficiaries, many continue to be burdened with unnecessary out-of-pocket (OOP) costs. Objective: This study sought to identify the frequency and impact of cost-lowering strategies used to assist Medicare beneficiaries with their Part D drug costs. Methods: Twelve outreach events were conducted in 6 different cities throughout Northern/Central California during the 2013 Medicare open enrollment period. During each event, trained student pharmacists under the supervision of licensed pharmacists assisted beneficiaries to minimize their OOP costs. Individualized assistance included: optimization of the beneficiary's Part D plan, …
Medicare Part D Prescription Drug Costs And Plan Satisfaction As A Function Of Student Pharmacists' Assistance, Rajul A. Patel, Kate M. O'Dell, Kenneth Wang, Shu Lu, Tiffany Chu, Kim-Anh Vo, Sian M. Carr-Lopez, Joseph A. Woelfel, Suzanne M. Galal, Berit Gundersen
Medicare Part D Prescription Drug Costs And Plan Satisfaction As A Function Of Student Pharmacists' Assistance, Rajul A. Patel, Kate M. O'Dell, Kenneth Wang, Shu Lu, Tiffany Chu, Kim-Anh Vo, Sian M. Carr-Lopez, Joseph A. Woelfel, Suzanne M. Galal, Berit Gundersen
School of Pharmacy Faculty Presentations
Background: Beneficiaries can become overwhelmed by the myriad of Medicare Part D (MPD) plans that offer prescription drug coverage. Poor choice and increased out-of-pocket (OOP) costs can be reduced through annual plan reevaluation. Objective: To examine beneficiaries' plan satisfaction and MPD drug costs as a function of prior assistance from trained student pharmacists. Methods: Twelve outreach events, nine at the same location as the previous year, were held throughout Northern/Central California during October-November 2012. Trained student pharmacists, at each event, identified the MPD plan best meeting a beneficiary's needs based on their current medications and personal preferences (e.g., preferred pharmacy). …
Sensing Charges Of The Ciona Intestinalis Voltage-Sensing Phosphatase, Carlos A. Villalba-Galea, Ludivine Frezza, Walter Sandtner, Francisco Bezanilla
Sensing Charges Of The Ciona Intestinalis Voltage-Sensing Phosphatase, Carlos A. Villalba-Galea, Ludivine Frezza, Walter Sandtner, Francisco Bezanilla
School of Pharmacy Faculty Articles
Voltage control over enzymatic activity in voltage-sensitive phosphatases (VSPs) is conferred by a voltage-sensing domain (VSD) located in the N terminus. These VSDs are constituted by four putative transmembrane segments (S1 to S4) resembling those found in voltage-gated ion channels. The putative fourth segment (S4) of the VSD contains positive residues that likely function as voltage-sensing elements. To study in detail how these residues sense the plasma membrane potential, we have focused on five arginines in the S4 segment of the Ciona intestinalis VSP (Ci-VSP). After implementing a histidine scan, here we show that four arginine-to-histidine mutants, namely R223H to …
Letter - Viewpoints: Scholarships, Through Generous Donors, Help Young People Realize Their Dreams, Pamela Eibeck
Letter - Viewpoints: Scholarships, Through Generous Donors, Help Young People Realize Their Dreams, Pamela Eibeck
Presidential Communications
No abstract provided.
Membrane Vesicles Nucleate Mineralo-Organic Nanoparticles And Induce Carbonate Apatite Precipitation In Human Body Fluids, Cheng-Yeu Wu, Jan Martel, Wei-Yun Cheng, Chao-Chih He, David M. Ojcius, John Ding-E. Young
Membrane Vesicles Nucleate Mineralo-Organic Nanoparticles And Induce Carbonate Apatite Precipitation In Human Body Fluids, Cheng-Yeu Wu, Jan Martel, Wei-Yun Cheng, Chao-Chih He, David M. Ojcius, John Ding-E. Young
All Dugoni School of Dentistry Faculty Articles
Recent studies indicate that membrane vesicles (MVs) secreted by various cells are associated with human diseases, including arthritis, atherosclerosis, cancer, and chronic kidney disease. The possibility that MVs may induce the formation of mineralo-organic nanoparticles (NPs) and ectopic calcification has not been investigated so far. Here, we isolated MVs ranging in size between 20 and 400 nm from human serum and FBS using ultracentrifugation and sucrose gradient centrifugation. The MV preparations consisted of phospholipid-bound vesicles containing the serum proteins albumin, fetuin-A, and apolipoprotein A1; the mineralization-associated enzyme alkaline phosphatase; and the exosome proteins TNFR1 and CD63. Notably, we observed that …
Identification Of Leptospira Interrogans Phospholipase C As A Novel Virulence Factor Responsible For Intracellular Free Calcium Ion Elevation During Macrophage Death, Jing-Fang Zhao, Hong-Hu Chen, David M. Ojcius, Xin Zhao, Dexter Sun, Yu-Mei Ge, Lin-Li Zheng, Xu'ai Lin, Lan-Juan Li, Jie Yan
Identification Of Leptospira Interrogans Phospholipase C As A Novel Virulence Factor Responsible For Intracellular Free Calcium Ion Elevation During Macrophage Death, Jing-Fang Zhao, Hong-Hu Chen, David M. Ojcius, Xin Zhao, Dexter Sun, Yu-Mei Ge, Lin-Li Zheng, Xu'ai Lin, Lan-Juan Li, Jie Yan
All Dugoni School of Dentistry Faculty Articles
Background: Leptospira-induced macrophage death has been confirmed to play a crucial role in pathogenesis of leptospirosis, a worldwide zoonotic infectious disease. Intracellular free Ca2+ concentration ([Ca2+]i) elevation induced by infection can cause cell death, but [Ca2+]i changes and high [Ca2+]i-induced death of macrophages due to infection of Leptospira have not been previously reported.
Methodology/Principal Findings: We first used a Ca2+-specific fluorescence probe to confirm that the infection of L. interrogans strain Lai triggered a significant increase of [Ca2+]i in mouse J774A.1 or human THP-1 macrophages. Laser confocal microscopic examination …
Pa Interactions With Law Enforcement, Jed Grant
Pa Interactions With Law Enforcement, Jed Grant
Physician Assistant Faculty & Staff Presentations
No abstract provided.
Connecting Multiculturalism, Sustainability, & Teacher Education: A Case For Linking Martin Luther King Streets & The Power Of Place, Charlane Starks
Connecting Multiculturalism, Sustainability, & Teacher Education: A Case For Linking Martin Luther King Streets & The Power Of Place, Charlane Starks
Benerd College Faculty Articles
In "The Shame of the Nation: The Restoration of Apartheid Schooling in America," Kozol (2005) asked a question that many educators and other education stakeholders still wonder about in regards to the educational progress for many urban school students in the United States, "What do we need to do to alter these realities?" (p. 215). Altering realities requires new questions and creatively connecting educational issues such as multiculturalism, education for a sustainable living, and teacher education in different ways. In this article author Charlane Starks ascribes an urban location to multiculturalism, sustainability, and teacher education to draw attention toward transforming …
Modulation Of The Effects Of Lung Immune Response On Bone Marrow By Oral Antigen Exposure, Pedro Xavier-Elsas, Cassio Luiz Coutinho Almeida-Da-Silva, L. Pinto, Túlio Queto, Bruno Marques Vieira, M. G. Aramha, Bianca De Luca, Daniela Masid-De-Brito, R. A. Luz, R. S. Lopes, R. Ferreira, Maria Ignez C. Gaspar-Elsas
Modulation Of The Effects Of Lung Immune Response On Bone Marrow By Oral Antigen Exposure, Pedro Xavier-Elsas, Cassio Luiz Coutinho Almeida-Da-Silva, L. Pinto, Túlio Queto, Bruno Marques Vieira, M. G. Aramha, Bianca De Luca, Daniela Masid-De-Brito, R. A. Luz, R. S. Lopes, R. Ferreira, Maria Ignez C. Gaspar-Elsas
All Dugoni School of Dentistry Faculty Articles
Allergic airway inflammation is attenuated by oral tolerization (oral exposure to allergen, followed by conventional sensitization and challenge with homologous antigen), which decreases airway allergen challenge-induced eosinophilic infiltration of the lungs and bone marrow eosinophilia. We examined its effects on bone marrow eosinophil and neutrophil production. Mice of wild type (BP-2, BALB/c, and C57BL/6) and mutant strains (lacking iNOS or CD95L) were given ovalbumin (OVA) or water (vehicle) orally and subsequently sensitized and challenged with OVA (OVA/OVA/OVA and H2O/OVA/OVA groups, resp.). Anti-OVA IgG and IgE, bone marrow eosinophil and neutrophil numbers, and eosinophil and neutrophil production ex vivo were evaluated. …
...Of Cabbages And Kings, September 2013, Emeriti Society, University Of The Pacific
...Of Cabbages And Kings, September 2013, Emeriti Society, University Of The Pacific
Emeriti Newsletter: "...Of Cabbages and Kings"
"...Of Cabbages and Kings" is the newsletter of the University of the Pacific Emeriti Society. Read more about the Emeriti Society of Pacific by clicking here.
Letter - Pacific's Bold Future, Pamela Eibeck
Letter - Pacific's Bold Future, Pamela Eibeck
Presidential Communications
No abstract provided.
Mechanism Of Ubiquitin Ligation And Lysine Prioritization By A Hect E3, Hari B. Kamadurai, Yu Qiu, Alan Deng, Joseph S. Harrison, Chris Macdonald, Marcelo Actis, Patrick Rodrigues, Darcie J. Miller, Judith Souphron, Steven M. Lewis, Igor Kurinov, Naoaki Fujii, Michal Hammel, Robert Piper, Brian Kuhlman, Brenda A. Schulman
Mechanism Of Ubiquitin Ligation And Lysine Prioritization By A Hect E3, Hari B. Kamadurai, Yu Qiu, Alan Deng, Joseph S. Harrison, Chris Macdonald, Marcelo Actis, Patrick Rodrigues, Darcie J. Miller, Judith Souphron, Steven M. Lewis, Igor Kurinov, Naoaki Fujii, Michal Hammel, Robert Piper, Brian Kuhlman, Brenda A. Schulman
College of the Pacific Faculty Articles
Ubiquitination by HECT E3 enzymes regulates myriad processes, including tumor suppression, transcription, protein trafficking, and degradation. HECT E3s use a two-step mechanism to ligate ubiquitin to target proteins. The first step is guided by interactions between the catalytic HECT domain and the E2∼ubiquitin intermediate, which promote formation of a transient, thioester-bonded HECT∼ubiquitin intermediate. Here we report that the second step of ligation is mediated by a distinct catalytic architecture established by both the HECT E3 and its covalently linked ubiquitin. The structure of a chemically trapped proxy for an E3∼ubiquitin-substrate intermediate reveals three-way interactions between ubiquitin and the bilobal HECT …
P2x4 Assembles With P2x7 And Pannexin-1 In Gingival Epithelial Cells And Modulates Reactive Oxygen Species Production And Inflammasome Activation, Shu-Chen Hung, Chul Hee Choi, Najwane Said-Sadier, Larry Johnson, Kalina Rosenova Atanasova, Hanen Sellami, Özlem Yilmaz, David M. Ojcius
P2x4 Assembles With P2x7 And Pannexin-1 In Gingival Epithelial Cells And Modulates Reactive Oxygen Species Production And Inflammasome Activation, Shu-Chen Hung, Chul Hee Choi, Najwane Said-Sadier, Larry Johnson, Kalina Rosenova Atanasova, Hanen Sellami, Özlem Yilmaz, David M. Ojcius
All Dugoni School of Dentistry Faculty Articles
We have previously reported that Porphyromonas gingivalis infection of gingival epithelial cells (GEC) requires an exogenous danger signal such as ATP to activate an inflammasome and caspase-1, thereby inducing secretion of interleukin (IL)-1β. Stimulation with extracellular ATP also stimulates production of reactive oxygen species (ROS) in GEC. However, the mechanism by which ROS is generated in response to ATP, and the role that different purinergic receptors may play in inflammasome activation, is still unclear. In this study, we revealed that the purinergic receptor P2X4 is assembled with the receptor P2X7 and its associated pore, pannexin-1. ATP induces ROS …
Sarah R. Graff And Enrique Rodriguez-Alegría, Eds. The Menial Art Of Cooking: Archaeological Studies Of Cooking And Food Preparation, Ken Albala
College of the Pacific Faculty Articles
No abstract provided.
2013/2014 University Of The Pacific Arthur A. Dugoni School Of Dentistry Catalog, University Of The Pacific
2013/2014 University Of The Pacific Arthur A. Dugoni School Of Dentistry Catalog, University Of The Pacific
Catalogue, Bulletin, Catalog
No abstract provided.
2013/2014 University Of The Pacific [Stockton] Graduate Catalog, University Of The Pacific
2013/2014 University Of The Pacific [Stockton] Graduate Catalog, University Of The Pacific
Catalogue, Bulletin, Catalog
No abstract provided.
An Automated Procedure For Detecting Human Frequency-Following Responses To Voice Pitch, Fuh Cherng Jeng, Jiong Hu
An Automated Procedure For Detecting Human Frequency-Following Responses To Voice Pitch, Fuh Cherng Jeng, Jiong Hu
All Faculty Scholarship
The frequency-following response (FFR) to voice pitch has been widely examined in research laboratories and has demonstrated its potential to be transformed into a useful tool for patients with hearing, speech, and language disorders in the clinic. During the past decade, many aspects of the FFR have been reported. The presence of such a response, however, still relies on subjective interpretation of the observer. Aside from a recent study reporting two algorithms for detecting such a response, there has been limited number of studies reporting the development of an automated procedure for FFR. The purpose of this study is (1) …
Influence Of Cochlear Implantation On Sentence Intelligibility And Duration, Olga Peskova, Nirmal Kumar Srinivasan, Sujin Shin, Madhu Sundarrajan, Emily Tobey
Influence Of Cochlear Implantation On Sentence Intelligibility And Duration, Olga Peskova, Nirmal Kumar Srinivasan, Sujin Shin, Madhu Sundarrajan, Emily Tobey
All Faculty Scholarship
Cochlear implants (CI) allow children with hearing loss (HL) to achieve speech perception and production outcomes that make their spoken speech understandable to normal hearing adult listeners. This capability is characterize by wide variability of scores. In order to understand the factors that contribute to the overall variability, we investigated the effects of duration of cochlear implantation on speech intelligibility and sentence duration over time. Participants were 107 children implanted between the ages of 2 and 4 and tested at 2 time points there they were 8 and 16 years old. Participants repeated McGarr sentences, which vary in length from …
Arthur A. Dugoni School Of Dentistry 119th Commencement, University Of The Pacific
Arthur A. Dugoni School Of Dentistry 119th Commencement, University Of The Pacific
Commencement Programs
No abstract provided.