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The Common Acid Sphingomyelinase Polymorphism P.G508r Is Associated With Self-Reported Allergy, Martin Reichel, Tanja Richter-Schmidinger, Christiane Muhle, Cosima Rhein, Panagiotis Alexopoulos, Sibylle G. Schwab, Erich Gulbins, Johannes Kornhuber
The Common Acid Sphingomyelinase Polymorphism P.G508r Is Associated With Self-Reported Allergy, Martin Reichel, Tanja Richter-Schmidinger, Christiane Muhle, Cosima Rhein, Panagiotis Alexopoulos, Sibylle G. Schwab, Erich Gulbins, Johannes Kornhuber
Illawarra Health and Medical Research Institute
Background: Acid sphingomyelinase (ASM) is a key regulator of ceramide-dependent signalling pathways. Among others, activation of ASM can be induced by CD95 or cytokine signalling and by cellular stress resulting from inflammation or infection. Increased ASM activity was observed in a variety of human diseases including inflammatory and neuropsychiatric disorders. We hypothesized that basal ASM activity might influence the susceptibility for common human diseases. Methods: The general health condition of 100 young people was assessed using a questionnaire. The ASM polymorphism rs1050239 (c.1522G>A; encoding p.G508R) was determined from genomic DNA. Activities of secretory (S-) and lysosomal (L-) ASM were …
Implementing A Latex Allergy Awareness, Avoidance And Management Strategy For Use In A Simulated Environment, Siobhan Wragg, Leeanne Heaton, Sharon Bourgeois
Implementing A Latex Allergy Awareness, Avoidance And Management Strategy For Use In A Simulated Environment, Siobhan Wragg, Leeanne Heaton, Sharon Bourgeois
Faculty of Science, Medicine and Health - Papers: part A
Abstract of poster presented at the SimHealth 2013 Conference.
Infant Feeding Practices And Nut Allergy Over Time In Australian School Entrant Children, James James Paton, Marjan Kljakovic, Karen Ciszek, Pauline Y. O'Shaughnessy
Infant Feeding Practices And Nut Allergy Over Time In Australian School Entrant Children, James James Paton, Marjan Kljakovic, Karen Ciszek, Pauline Y. O'Shaughnessy
Faculty of Engineering and Information Sciences - Papers: Part B
To measure the association between infant feeding practices and parent-reported nut allergy in school entrant children. Method. The Kindergarten Health Check Questionnaire was delivered to all 110 Australian Capital Territory (ACT) primary schools between 2006 and 2009. Retrospective analyses were undertaken of the data collected from the kindergarten population. Results. Of 15142 children a strong allergic reaction to peanuts and other nuts was reported in 487 (3.2%) and 307 (3.9%), children, respectively. There was a positive association between parent reported nut allergy and breast feeding (OR = 1.53; 1.11–2.11) and having a regular general practitioner (GP) (OR = 1.42; 1.05–1.92). …