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Synthesis Of Novel Compounds Based On Reticuline Scaffold For New Drugs Discovery, Tam-Dan Batenburg-Nguyen

University of Wollongong Thesis Collection 1954-2016

This thesis examines the synthesis of a library of benzyl- and bisbenzylisoquinolines (BBI) derivatives based on the reticuline motif. These compounds were assessed for their; i) cytotoxicity on 3 cancer cell lines, ii) activity on HIV-infected cells, iii) antibacterial activity, and iv) CNS receptor binding affinities. Chapter 2 describes the employment of palladium-catalysed Stille, Heck and Sonogashira coupling reactions to synthesise a library of BBI derivatives. 2’-Vinyl- (67), 2’-allyl- (68) and 2’-iodo (58) derivatives of racemic, N-TFA protected, norlaudanosine were used as the key building blocks in this investigation. The key 2’-vinyl- and 2’-allyl-norlaudanosine derivatives 67 and 68, respectively were …

Predator-Prey Interactions In The Spinifex Grasslands Of Central Australia, Rachel M. Paltridge

University of Wollongong Thesis Collection 1954-2016

Predation by exotic predators (cats Felis catus and foxes Vulpes vulpes) is believed to be one of the factors that has contributed to the decline of medium-sized mammals in arid Australia. Other factors include habitat degradation by introduced herbivores (rabbits Oryctolagus cuniculus and grazing stock) and altered fire regimes after Aboriginal people moved into permanent settlements. In general, the impact of exotic predators on arid zone mammals is believed to be significant only when predator numbers have been elevated by increased food availability from exotic prey species (rabbits, house-mice Mus domesticus, cattle carcasses) or when native prey populations have already …

Effects Of Aerobic And Resistance Training On Insulin Sensitivity, Muscle Composition And Dietary Fat Intake, Adam Fraser

University of Wollongong Thesis Collection 1954-2016

Insulin resistance (IR) is thought to be a major aetiological factor in the development in type II diabetes and the Metabolilc Syndrome, yet the underlying mechanisms behind IR remain unknown. Both resistance (RT) and aerobic (AT) exercise training lead to an increase in insulin sensitity (IS), however it is uncertain as to whether the effect of exercise on IS extends beyond the last exercise bout and which mode of exercise (RT or AT) is most beneficial. A human exercise intervention trial comparing the effect of RT and AT on insulin sensitivity measured 72 hours after the last exercise bout was …

Outlaws And Their Mortgages: An Analysis Of The Property (Relationships) Act 1984 (Nsw), Erin Elizabeth Cahill

University of Wollongong Thesis Collection 1954-2016

This thesis is an exploration of the Property (Relationships) Act 1984 (NSW) (the PRA). This piece of legislation instituted what was, at the time, the most progressive and furthest reaching recognition of same sex relationships within the Australian legislative system. Whilst recognising the important implications of the PRA, there are two remarkable features of this legislation upon which this thesis focuses. First, it instituted a legally sanctioned hierarchy of relationship types within Australian law, in terms of legal rights and enablement. Marriage sits at the top of this hierarchy, governed at both the state and the federal levels in Australia. …

Piracy Protection In Content Distribution Systems, Dongvu Tonien

University of Wollongong Thesis Collection 1954-2016

In this thesis, we consider the traitor tracing problem. We study codes with different traceability properties and public key traitor tracing schemes. We study maximal codes with 2-identifiable parent property. Using graph theoretic techniques, we determine the structure of the graph representation of maximal codes of length three having 2-identifiable parent property, and derive the number of codewords in such codes. Maximal 2-identifiable parent property codes of length four have recently been studied. It is still an open problem to determine the size and structure of a maximal 2-identifiable parent property code of length greater than four. We present a …

Journalism At Risk: Factors Influencing Journalistic Coverage Of The Gm Food And Crops Debate (Australia, 1999-2001) And Prospects For Critical Journalism, Anna Salleh

University of Wollongong Thesis Collection 1954-2016

This thesis examines factors shaping journalistic coverage of risk debates involving new technologies, using the Australian debate over genetically modified/manipulated (GM) food and crops during the period 1999-2001. It argues for a more thorough application of constructivism in risk journalism scholarship, and a more sophisticated application of the conflict frame in risk journalism practice. Theoretical tools for analysing risk journalism are developed from empirical research and a broad range of literatures. Prospects for one particular type of critical risk journalism, which is based on insights from science and technology studies (STS), are explored. The thesis first documents the forceful communication …

The Importance Of Information Systems In Inter-Sectoral R&D Collaboration: The Case Of The Australian Co-Operative Research Centre (Crc) Program, Gogor Oko Nurharyoko

University of Wollongong Thesis Collection 1954-2016

Currently, in the process of creating innovation, some new forms of R & D collaboration are emerging, to fulfil the demands of the knowledge-based systems that must integrate industrial, scientific and commercial elements. These new forms are normally based on an integration of several participants from different institutions becoming involved in an inter- sectoral collaboration. This has been the subject of intensive study in most industrialized countries including Australia since 1980s. The Co-operative Research Centre is the Australian Government�s answer to this new emerging phenomenon. With the growing numbers of inter-sectoral collaborations especially aimed at innovation, the development of new …

Financial Liberalisation In Nepal, Min Bahadur Shrestha

University of Wollongong Thesis Collection 1954-2016

This study examines the overall impact of financial liberalisation on Nepal�s financial system and economy. The study is specifically directed towards analysing the rationale of executing a financial liberalisation policy; preparing an account of the evolution, process and sequencing of the financial liberalisation; and evaluating the impact of the various liberalisation measures on financial and economic developments of Nepal with cointegration and causality tests. The study makes significant contributions in the area of the impact evaluation of financial liberalisation. Most of the previous studies focus on the economic growth aspect of financial liberalisation in detail, but attach less importance to …

Sunburnt Sea Snails: The Role Of Ultraviolet Radiation In The Development Of Encapsulated Embryos From Temperate Rocky Shores, Rachel Przeslawski

University of Wollongong Thesis Collection 1954-2016

Ultraviolet radiation (UVR) is an important abiotic stressor for both acquatic and terrestrial organisms. The recent anthropogenic depletion of stratospheric ozone has resulted in elevated levels of potentially damaging UV-B to which organisms are exposed, and global climate change many also herald changes in environmental conditions, particularly temperature, precipitation, and sea level. Thus, organisms may be simultaneously exposed to variable environmental stressors. In the marine environment, embryos and larvae are likely the most vulnerable to the negative effects of these stresses. Moreover, intertidal organisms are particularly vulnerable to UVR because they occur in habitats where little or no UVR is …

The Effectiveness Of Structured Food Pattern Advice For Achievement Of Macronutrient Targets In Nutrition Intervention, Lynda J. Gillen

University of Wollongong Thesis Collection 1954-2016

Dietary advice to individuals in Medical Nutrition Therapy for the prevention and treatment of disease should be based on the best available evidence. A review of the evidence identifies appropriate nutrients on which to base advice. However, evidence to support the application of advice for the achievement of nutrient targets in free-living individuals has not been adequately determined. In this doctoral program the hypothesis tested was that structured advice based on the pattern of intake from food group sources of required nutrients will result in better achievement of dietary targets and thereby clinical outcomes than advice based on existing core …

The Controlled Ball Milling Of Titanium And Carbon To Form Tic, Benjamin H. Lohse

University of Wollongong Thesis Collection 1954-2016

The aim of this work is to improve the understanding of the reaction to form titanium carbide (TiC) during the high-energy milling of titanium and carbon powder mixtures because a more thorough understanding of this reaction is required if high-energy milling is to be developed as a commercially viable process for the production of TiC and/or TiC-Ti powders. Titanium and activated carbon powder mixtures with compositions of Ti100-xCx (x = 50, 40, 30) were milled under a helium atmosphere using a magneto ball mill. For Ti50C50 and Ti60C40 powder mixtures milled in the higher milling energy impact mode, the combined …

Developing A Model Of Peer Collaborating In E-Learning That Can Be Applied To The Png Context, Lalen Julieanna Simeon

University of Wollongong Thesis Collection 1954-2016

There is an expectation that lecturers should be equipped with the skills needed to apply technology to support and enhance learning in their subjects. For many lecturers, the increasing emphasis on the use of ICT for research and teaching can be threatening, but these fears can be eased if professional development is supportive and ongoing, and provided in flexible, appropriate and adaptable ways. This study focused on collaboration strategies employed by four lecturers and two instructional designers (IDs) as they worked together to develop online learning environments as well as other types of learning resources. It focuses on two case …

Cryptographic Privacy Enhancing Technologies, Lan Duy Nguyen

University of Wollongong Thesis Collection 1954-2016

The growth of information and communication technology creates difficulties for individuals to monitor and control their private information which can be copied, transferred from one location to another within a second and accessible to many people. This thesis focuses on a number of cryptographic technologies, which have been introduced and developed to protect user privacy, including anonymous signatures, anonymous authentication, anonymous credentials and anonymous routing. Our contributions to these technologies are in three aspects: more efficiency, more security and better functionality. We identify and formalize new security requirements, and improve and build formal security models for a number of privacy-preserving …

Removal Of Emerging Trace Organic Contaminants By Nanofiltration And Reverse Osmosis, Long Nghiem

University of Wollongong Thesis Collection 1954-2016

This study investigates the retention mechanisms of three prominent classes of emerging trace organic contaminants . natural steroid hormones, hormone mimicking compounds, and pharmaceutically active compounds . by several nanofiltration (NF) and reverse osmosis membranes. Laboratory-scale experiments were carried out using both cross flow and dead end stirred cell filtration equipment with the goal of relating trace organic retention behaviour to membrane characteristics, physicochemical properties of the trace organic molecules, and solution chemistry. The results reported here show that retention of neutral trace organics by a tight NF or RO membrane is dominated by steric (size) exclusion, whereas both electrostatic …

Palaeoenvironments Of The Gulf Of Carpentaria From The Last Glacial Maximum To The Present, As Determined By Foraminiferal Assemblages, Sabine Holt

University of Wollongong Thesis Collection 1954-2016

This thesis presents a palaeoenvironmental study of the Gulf of Carpentaria, northern Australia, from around the Last Glacial Maximum (LGM) to the present. Foraminifers, microscopic unicellular aquatic organisms, occur throughout the sediment in the time frame studied. Data on the species composition and preservation of the microfossils found in the Gulf of Carpentaria cores are utilised to reconstruct past environments by comparison to the known assemblages of living foraminifers in various modern environments. The Gulf of Carpentaria is a shallow epicontinental sea, situated between Australia and Papua New Guinea, and is a maximum of 70m deep. It is separated from …

Methodologies For Information Source Selection Under Distributed Information Environments, Hui Yang

University of Wollongong Thesis Collection 1954-2016

The information revolution is upon us. In fact, we are increasingly overwhelmed by the exponential growth of information on the Web. The profusion of resources on the Web has given rise to considerable interest in the research of information retrieval. Traditional information retrieval techniques are facing new challenges in distributed information environments such as the Internet. One of the more important research issues is information source selection, which is to select a small number of information sources that may contain most of the potentially useful documents when a user information need is presented. This thesis investigates new methodologies for information …

Rapid Adaptive Programming Using Image Data, Alexander D. Nicholson

University of Wollongong Thesis Collection 1954-2016

This work was initiated to address the problem of automated weld repair in a specific application; namely hydro turbine cavitation damage. An extensive review of the application requirements was undertaken and this highlighted the need for a new approach to robot programming. This thesis therefore focused on the development of a novel rapid programming technique based on a vision system. The implementation involved the development of algorithms to correlate robot and vision system coordinates, communication links to the system hardware, and a software environment to ‘manage’ the process. The complete system was successfully validated by representative trials on a full-size …

The Antecedents And Consequences Of The Marketing Manager And R&D Manager Working Relationship During New Product Development: An Empirical Study, Elias Kyriazis

University of Wollongong Thesis Collection 1954-2016

The antecedents and consequences of 'interdepartmental working relations' have been examined in detail in the new product development (NPD) literature, however, less attention has been given to the relationship between functional managers at the interpersonal level. The study presented in this thesis developed and empirically tested a model of the antecedents and consequences of the working relationship between the Marketing Manager and R&D Manager at the NPD project level. By including interpersonal trust as a two-dimensional construct (affective and cognitive-based trust) and conceptualising it as a key mediating variable, the study provides great explanatory power regarding the interplay of important …

Stormwater Impacts On Discharge Water Quality In Licensed Drains At The Port Kembla Steelworks, Louis Mathew Whant

University of Wollongong Thesis Collection 1954-2016

This study encompassed work on four of the Environment Protection Authority (EPA) licensed discharge points at the Port Kembla Steelworks (PKSW). These included the North Gate Drain, the Main Drain, the Flat Products East No.1 Drain and the Ironmaking East Drain. This study incorporated a hydrological study of the drains, and a stormwater discharge water quality study. The aims of the hydrological component were: to obtain an understanding of the behaviour of each of these drains during rainfall events; to determine fractions of runoff compared to rainfall volume; to determine the influence antecedent precipitation has on the discharge of each …

Non-Resident Cinema: Transnational Audiences For Indian Films, Adrian Mabbott Athique

University of Wollongong Thesis Collection 1954-2016

In this thesis the popular Indian film is described as an object of global significance. It is argued that understanding Indian films on a global scale requires different governing structures to existing paradigms of national media research and that, in particular, this requires a focus upon the consumption, rather than the production, of cinema. This thesis will also argue that the Australian media environment is constituted by a complex matrix of transnational cultural flows that spread beyond the boundaries of nationalist discourse, and that understanding the social dynamics of cinema in Australia requires an intellectual engagement with the phenomenon of …

Fault Lines In The World Trade Organization: An Analysis Of The Trips Agreement And Developing Countries, Daya Shanker

University of Wollongong Thesis Collection 1954-2016

The thesis examines the role and position of developing countries in the World Trade Organization (WTO) in relation to the Agreement on Trade Related Aspects of Intellectual Property Rights (TRIPS). The analysis was done through three case studies involving major developing countries such as Brazil, India and Argentina, major developed country such as the USA and the regional trading bloc, the EC. The case studies identified a number of areas of conflict such as the exemptions under Article 30 of the TRIPS Agreement, compulsory licensing under Article 31 of TRIPS, the exhaustion of rights after sale of the patented products …

A Discursive Analysis Of The Relationships Between Instruction, Learning And The Development Of The Higher Mental Processes During Dialogues About Writing Between A Teacher And Three Five-Year-Old Children During Their First Year Of Formal Education, Peter Charles Geekie

University of Wollongong Thesis Collection 1954-2016

This thesis reports on an observational study using data collection methods which were ethnographic in spirit. The primary data consisted of video recordings of a teacher talking to each of three five-year-old children as they attempted to write simple written language texts. Five such sessions were recorded for each child during the school year. The inquiry was based upon the assumption that most could be learnt about literacy learning by observing successful learners. All three children learnt to write during the year of observation. While prolonged engagement on the research site, and the use of field notes and informants is …

A Moral Law For The Jungle: A Kantian Exploration In Corporate Environmental Ethics, Fabian P. D. Sack

University of Wollongong Thesis Collection 1954-2016

Almost global acknowledgement of environmental crisis and social inequity suggest a secular revision of Kantian moral philosophy embracing sustainability. By eschewing subjective preferences as the foundation of morality Kant avoids an aspect of corporate responsibility that has otherwise proved intractable. Corporations, as artificial and disembodied agents, cannot depend on desires or intuitions to guide their actions. Kant's moral theory avoids subjective preferences that arbitrarily exclude our environments, communities or future generations from moral relevance and corporations from moral responsibility. Kant says: 'Let no one think that here the trivial 'quod tibi no vis fieri, etc.' [Don't do unto others what …

Groundwater Remediation Using A Coal Washery Discard Permeable Reactive Wall, Stuart Gray

University of Wollongong Thesis Collection 1954-2016

Groundwater remediation has become increasingly necessary for environmental sustainability in industrial, agricultural and urban settings. One reason for this need has been the emplacement of rock waste materials (e.g. coal washery discard (CWD) and blast furnace slag (BFS)) from mining and metallurgical industries in areas such as the Illawarra region of New South Wales. Since there has been a lack of rigorous research into the potential for these emplacements to pollute groundwater, the majority of these emplacements were constructed without the installation of engineering leachate controls. Indeed, until research over the last 15 to 20 years proved the contrary, available …

Using Multipath Fading To Increase Performance Of Wireless Communication Systems, Phillip Conder

University of Wollongong Thesis Collection 1954-2016

For impending wireless communications networks, such as 3rd Generation Mobile networks and Wireless Local Area Networks, there is a greater emphasis on providing higher data rates and improved quality in terms of reliability over multipath fading channels. The area of Multiple Input Multiple Output (MIMO) communications systems has received enormous attention recently, as they can provide a roughly linear increase in data rate by using multiple transmit and receive antennas. In a future, where communication systems may implement MIMO technology, mobile user terminals are desired to be small, lightweight and have extended battery life. This seems at odds with MIMO …

Sintering, Microstructure And Properties Of Wc-Feal-B And Wc-Ni3al-B Composite Materials, Mehdi Ahmadian-Najafabadi

University of Wollongong Thesis Collection 1954-2016

The effect of boron on microstructure and mechanical properties of the intermetallic matrix composites (WC-FeAl-B and WC-Ni3Al-B) were investigated. The results were compared with those obtained from WC-Co composite which had same binder volume fraction and fabricated under identical sintering conditions. Boron doped FeAl (FeooA14o) and NhAl alloys were selected as potential new alternative binders in place of cobalt for WC composites due to their particular combination of mechanical properties.

Sub micron WC-40vol%(FeAl-B), WC40vol%(NhAl-B) and WC-4Ovol%Co composites were synthesized by powder processing followed by uniaxial hot-pressing at the optimized temperature of 1500 °C under a pressure of20 MFa in argon …

To Develop And Trial A New Warfarin Education Program, Judy Mullan

University of Wollongong Thesis Collection 1954-2016

The principal purpose of this study was to identify, develop and trial a new warfarin education program to enhance warfarin knowledge, management and compliance in a wider patient population, inclusive of the ‘high risk’ group. This ‘high risk’ group included patients who were elderly, had low literacy skills and came from non-English speaking backgrounds. Effective patient education is a central part of the practice of all health professionals because it helps to ensure safe and effective warfarin management. With recent increases in warfarin prescribing and warfarin-related adverse drug events the need for an effective patient warfarin education program is more …

Effects Of Household Footwear-Surface Interactions On The Gait Of Older Arthritic Females, Bridget J. Munro

University of Wollongong Thesis Collection 1954-2016

Inappropriate footwear, poor footwear-surface interactions and gait adaptations resulting from musculoskeletal problems, such as arthritis and foot problems, are all factors that contribute to home slips. However, no research was located which identified the effects of interactions between household footwear and household surface characteristics on variables that may predispose older individuals to fall in the home. Therefore, the purpose of this thesis was to identify how different household shoe-surface interactions affected the gait of older people, particularly those with foot problems, to recommend a “safe” household shoe for older people. To achieve this purpose, this thesis was completed in two …

Theatre Internationalisation: A Vietnamese Perspective, Dinh Thi Nguyen

University of Wollongong Thesis Collection 1954-2016

During the last century, there have been many international theatrical exchanges which provided theatre practitioners with a wide range of opportunities to adapt and borrow elements or techniques from one theatre culture to apply to another. However, the question remains, whether this process is a collaboration in which 'foreign' elements equally exist with the original tradition, creating a new form or are they assimilated into the tradition and absorbed by it? Do 'foreign' elements remain foreign, used within familiar structures? In this thesis I map out a conceptual framework for analysing a number of related practices in adapting and borrowing …

The Application Of The Fmea Risk Assessment Technique To Electronic Health Record Systems, Khin Than Win

University of Wollongong Thesis Collection 1954-2016

Patient safety and Medical errors are of growing concern in the health care industry. Some errors are caused by preventable adverse events; identifying potential errors and preventing them would mitigate risk and hence enhance the safety. Electronic health records (EHRs) are an inherent part of the healthcare systems and thus it is imperative that errors do not originate from EHRs. A thorough literature review indicated that no risk assessment methods currently exist for EHR systems. Project management risk and system security risk assessments do exist but not risk assessment of threats to safety. Accordingly, this research aims to develop a …