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Anxiety And Social Withdrawal Among Children: Associations With Emotion Awareness And Emotion Regulation Strategy Use At The Intra- And Interpersonal Levels, Janae Ellen Teer Aug 2021

Anxiety And Social Withdrawal Among Children: Associations With Emotion Awareness And Emotion Regulation Strategy Use At The Intra- And Interpersonal Levels, Janae Ellen Teer

Theses and Dissertations

Anxiety and social withdrawal are two frequently experienced internalizing conditions among children. These early-onset challenges are associated with numerous maladaptive outcomes in the academic, social, and psychological domains (Levitt & Merrill, 2009; Long, 2018; Sanchez et al., 2018; Shernoff et al., 2017). While identifying anxious and socially withdrawn children in the classroom is difficult as symptoms generally occur internally, distinguishing between the conditions is perhaps more challenging as the two are closely associated, oftentimes overlapping constructs (Barzeva et al., 2019; Rubin et al., 2009). Particularly, it is unclear whether anxiety and social withdrawal are similarly or differently associated with key …


Neural Substrates Of Fear Generalization And Its Associations With Anxiety And Intolerance Of Uncertainty, Ashley Ann Huggins Aug 2021

Neural Substrates Of Fear Generalization And Its Associations With Anxiety And Intolerance Of Uncertainty, Ashley Ann Huggins

Theses and Dissertations

Fear generalization - the tendency to interpret ambiguous stimuli as threatening due to perceptual similarity to a learned threat – is an adaptive process. Overgeneralization, however, is maladaptive and has been implicated in a number of anxiety disorders. Neuroimaging research has indicated several regions sensitive to effects of generalization, including regions involved in fear excitation (e.g., amygdala, insula) and inhibition (e.g., ventromedial prefrontal cortex). Research has suggested several other small brain regions may play an important role in this process (e.g., hippocampal subfields, bed nucleus of the stria terminalis [BNST], habenula), but, to date, these regions have not been examined …


Behavioral, Physiological, And Molecular Characterization Of Long-Term Administration Of A Novel Estrogen Receptor Beta Agonist In A Mouse Model Of Menopause, Aaron William Fleischer May 2021

Behavioral, Physiological, And Molecular Characterization Of Long-Term Administration Of A Novel Estrogen Receptor Beta Agonist In A Mouse Model Of Menopause, Aaron William Fleischer

Theses and Dissertations

The menopausal loss of circulating hormones, including estrogens, is associated with negative symptoms, such as hot flashes, anxiety and depression, cognitive decline, and weight gain. Although estrogenic hormone therapies (HT) prevent many of the negative symptoms related to the menopausal transition, these same therapies are associated with increased health risks, such as the development of breast and ovarian cancers, which is mediated by the activation of the a (ERa), but not b (ERb), estrogen receptor isoform. Furthermore, ERb agonism has previously been shown to reduce preclinical indices of hot flashes, memory decline, anxiety, and depression. As most ERb agonists are …


Neural Correlates Underlying The Interactions Between Anxiety And Cannabis Use In Predicting Motor Response Inhibition, Richard Ward May 2021

Neural Correlates Underlying The Interactions Between Anxiety And Cannabis Use In Predicting Motor Response Inhibition, Richard Ward

Theses and Dissertations

The ability to effectively withhold an inappropriate response is a critical feature of cognitive control. Prior research indicates alterations in neural processes required for motor response inhibition in anxious individuals, including those with posttraumatic stress disorder (PTSD), and those who engage in regular cannabis use. However, thus far most research has examined how anxiety-related symptoms and cannabis use influence response inhibition in isolation of one another. The current study examined the interactions between anxious symptomology and recent cannabis use in a sample that recently experienced a traumatic event using functional magnetic resonance imaging (fMRI) during the completion of a Stop-Signal …