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The Effect Of Bmal1 On Intestinal Tumourigenesis, Chantelle Trombley
The Effect Of Bmal1 On Intestinal Tumourigenesis, Chantelle Trombley
Electronic Theses and Dissertations
The circadian clock is an endogenous cycle that temporally coordinates physiological and behavioural processes with the Earth’s rotation about its axis. This molecular clock has been proposed to control multiple fundamental biological processes such as metabolism, cell cycle and proliferation-processes in which abnormalities have been shown to be tumourigenic. Epidemiological studies suggest shift workers are at an increased risk for various cancers including breast and colorectal cancer. Colorectal cancer is initiated by mutations to the Adenomatous Polyposis Coli (APC) gene in which loss of heterozygosity results in constitutive Wnt signaling, resulting in increased cellular proliferation. Previous work done in the …
Light And Feeding Cues: Entraining Circadian Rhythms In Chinook Salmon Tissues, Maryam Thraya
Light And Feeding Cues: Entraining Circadian Rhythms In Chinook Salmon Tissues, Maryam Thraya
Electronic Theses and Dissertations
The circadian clock is known to help organisms synchronize their behaviour and physiology with the external environment. Present in almost all cells, the clock is made up of a transcription-translation feedback loop that is responsive to cues such as light and feeding. This clock functions to influence the timing of various processes within the cells by promoting gene expression at optimal timing. Chinook salmon (Oncorhynchus tshawytscha) is an important aquaculture species whose clock has not been characterized yet. The aim of the work presented here is to probe for the expression of circadian clock genes in some tissues of Chinook …