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Mechanisms Of Fibrosis In Regeneration Of Aged Skeletal Muscle, Fasih Ahmad Rahman
Mechanisms Of Fibrosis In Regeneration Of Aged Skeletal Muscle, Fasih Ahmad Rahman
Electronic Theses and Dissertations
Skeletal muscle is a highly adaptive tissue that possesses the ability to regenerate following damage. Regenerative capacity of skeletal muscle declines as age advances, leading to restricted mobility and poor quality of life. The impairment of the regeneration process in aged muscle is partly due to the accumulation of structural proteins in the extracellular matrix (ECM), termed fibrosis. In this study, two important proteins regulating ECM remodeling, plasminogen activator inhibitor-1 (PAI-1) and matrix metalloproteinase-9 (MMP-9), were investigated to determine their role in modulating changes in the ECM during aged muscle regeneration. The regeneration process was studied in young (3 month …