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Articles 1 - 21 of 21
Full-Text Articles in Entire DC Network
Neuroprotective Effects Of Human Amniotic Fluid Stem Cells-Derived Secretome In An Ischemia/Reperfusion Model, Vanessa Castelli, Ivana Antonucci, Michele D'Angelo, Alessandra Tessitore, Veronica Zelli, Elisabetta Benedetti, Claudio Ferri, Giovambattista Desideri, Cesar Borlongan, Liborio Stuppia, Annamaria Cimini
Neuroprotective Effects Of Human Amniotic Fluid Stem Cells-Derived Secretome In An Ischemia/Reperfusion Model, Vanessa Castelli, Ivana Antonucci, Michele D'Angelo, Alessandra Tessitore, Veronica Zelli, Elisabetta Benedetti, Claudio Ferri, Giovambattista Desideri, Cesar Borlongan, Liborio Stuppia, Annamaria Cimini
Neurosurgery and Brain Repair Faculty Publications
Stem cells offer the basis for the promotion of robust new therapeutic approaches for a variety of human disorders. There are still many limitations to be overcome before clinical therapeutic application, including a better understanding of the mechanism by which stem cell therapies may lead to enhanced recovery. In vitro investigations are necessary to dissect the mechanisms involved and to support the potential development in stem cell-based therapies. In spite of growing interest in human amniotic fluid stem cells, not much is known about the characteristics of their secretome and regarding the potential neuroprotective mechanism in different pathologies, including stroke. …
Untreated Stroke As Collateral Damage Of Covid-19: "Time Is Brain" Versus "Stay At Home"., David Z. Rose, W. Scott Burgin, Swetha Renati
Untreated Stroke As Collateral Damage Of Covid-19: "Time Is Brain" Versus "Stay At Home"., David Z. Rose, W. Scott Burgin, Swetha Renati
All publications
For decades, neurologists have been advocating that anyone with acute focal deficits report immediately to the closest hospital's emergency room. Major advancements in the hyperacute diagnosis and treatment of stroke have justified our call-to-action slogan of "Time is Brain"-faster therapy leads to superior outcomes. However, this mantra has been recently usurped by the catchphrase "Stay at Home" during the coronavirus disease 2019 (COVID-19) pandemic. Fewer patients are presenting to hospitals with acute stroke; our census is down. Presumably the etiology of this phenomenon is either strict "social distancing" that some people may misperceive to exclude even emergent situations, or fears …
Untreated Stroke As Collateral Damage Of Covid-19: “Time Is Brain” Versus “Stay At Home”:, David Z. Rose, W. Scott Burgin, Swetha Renati
Untreated Stroke As Collateral Damage Of Covid-19: “Time Is Brain” Versus “Stay At Home”:, David Z. Rose, W. Scott Burgin, Swetha Renati
All publications
For decades, neurologists have been advocating that anyone with acute focal deficits report immediately to the closest hospital’s emergency room. Major advancements in the hyperacute diagnosis and treatment of stroke have justified our call-to-action slogan of “Time is Brain”—faster therapy leads to superior outcomes. However, this mantra has been recently usurped by the catchphrase “Stay at Home” during the coronavirus disease 2019 (COVID-19) pandemic. Fewer patients are presenting to hospitals with acute stroke; our census is down. Presumably the etiology of this phenomenon is either strict “social distancing” that some people may misperceive to exclude even emergent situations, or fears …
Untreated Stroke As Collateral Damage Of Covid-19: “Time Is Brain” Versus “Stay At Home, David Z. Rose, W. Scott Burgin, Swetha Renati
Untreated Stroke As Collateral Damage Of Covid-19: “Time Is Brain” Versus “Stay At Home, David Z. Rose, W. Scott Burgin, Swetha Renati
Neurology Faculty Publications
For decades, neurologists have been advocating that anyone with acute focal deficits report immediately to the closest hospital’s emergency room. Major advancements in the hyperacute diagnosis and treatment of stroke have justified our call-to-action slogan of “Time is Brain”—faster therapy leads to superior outcomes. However, this mantra has been recently usurped by the catchphrase “Stay at Home” during the coronavirus disease 2019 (COVID-19) pandemic. Fewer patients are presenting to hospitals with acute stroke; our census is down. Presumably the etiology of this phenomenon is either strict “social distancing” that some people may misperceive to exclude even emergent situations, or fears …
Eyeballing Stroke: Blood Flow Alterations In The Eye And Visual Impairments Following Transient Middle Cerebral Artery Occlusion In Adult Rats, Jea-Young Lee, Vanessa Castelli, Brooke Bonsack, Julián García-Sánchez, Chase Kingsbury, Hung Nguyen, Naoki Tajiri, Cesar V. Borlongan
Eyeballing Stroke: Blood Flow Alterations In The Eye And Visual Impairments Following Transient Middle Cerebral Artery Occlusion In Adult Rats, Jea-Young Lee, Vanessa Castelli, Brooke Bonsack, Julián García-Sánchez, Chase Kingsbury, Hung Nguyen, Naoki Tajiri, Cesar V. Borlongan
Neurosurgery and Brain Repair Faculty Publications
Middle cerebral artery occlusion in rodents remains a widely used model of ischemic stroke. Recently, we reported the occurrence of retinal ischemia in animals subjected to middle cerebral artery occlusion, owing in part to the circulatory juxtaposition of the ophthalmic artery to the middle cerebral artery. In this study, we examined the eye hemodynamics and visual deficits in middle cerebral artery occlusion-induced stroke rats. The brain and eye were evaluated by laser Doppler at baseline (prior to middle cerebral artery occlusion), during and after middle cerebral artery occlusion. Retinal function-relevant behavioral and histological outcomes were performed at 3 and 14 …
Cell Therapy For Central Nervous System Disorders: Current Obstacles To Progress, Takao Yasuhara, Satoshi Kawauchi, Kyohei Kin, Jun Morimoto, Masahiro Kameda, Tatsuya Sasaki, Brooke Bonsack, Chase Kingsbury, Naoki Tajiri, Cesar V. Borlongan, Isao Date
Cell Therapy For Central Nervous System Disorders: Current Obstacles To Progress, Takao Yasuhara, Satoshi Kawauchi, Kyohei Kin, Jun Morimoto, Masahiro Kameda, Tatsuya Sasaki, Brooke Bonsack, Chase Kingsbury, Naoki Tajiri, Cesar V. Borlongan, Isao Date
Neurosurgery and Brain Repair Faculty Publications
Cell therapy for disorders of the central nervous system has progressed to a new level of clinical application. Various clinical studies are underway for Parkinson's disease, stroke, traumatic brain injury, and various other neurological diseases. Recent biotechnological developments in cell therapy have taken advantage of the technology of induced pluripotent stem (iPS) cells. The advent of iPS cells has provided a robust stem cell donor source for neurorestoration via transplantation. Additionally, iPS cells have served as a platform for the discovery of therapeutics drugs, allowing breakthroughs in our understanding of the pathology and treatment of neurological diseases. Despite these recent …
An Eye Opener In Stroke: Mitochondrial Dysfunction And Stem Cell Repair In Stroke-Induced Retinal Ischemia, Hung Vu Thien Nguyen
An Eye Opener In Stroke: Mitochondrial Dysfunction And Stem Cell Repair In Stroke-Induced Retinal Ischemia, Hung Vu Thien Nguyen
USF Tampa Graduate Theses and Dissertations
Stoke is a leading cause of disability and mortality across the globe, making it a global health crisis. However, treatments for stroke remain limited with narrow therapeutic time window. Visual impairment negatively affects patients’ quality of life. During stroke, the disruption in blood flow might affect both brain and eye resulting in cerebral and retinal ischemia. Currently, there is a lack of treatment option that targets both cerebral and retinal ischemia. Ischemic stroke pathology is complex and multiphasic. The ischemic event is followed by a secondary cascade of inflammatory cytokines exacerbating the initial focal injury and expanding into the penumbra. …
Pathophysiology Of Ganglioside Gm1 In Ischemic Stroke: Ganglioside Gm1: A Critical Review, Wenchao Zhang, Paul R. Krafft, Tianlong Wang, John H. Zhang, Li Li, Jiping Tang
Pathophysiology Of Ganglioside Gm1 In Ischemic Stroke: Ganglioside Gm1: A Critical Review, Wenchao Zhang, Paul R. Krafft, Tianlong Wang, John H. Zhang, Li Li, Jiping Tang
Neurosurgery and Brain Repair Faculty Publications
Ganglioside GM1 is a member of the ganglioside family which has been used in many countries and is thought of as a promising alternative treatment for preventing several neurological diseases, including cerebral ischemic injury. The therapeutic effects of GM1 have been proved both in neonates and in adults following ischemic brain damage; however, its clinical efficacy in patients with ischemic stroke is still uncertain. This review examines the recent knowledge of the neuroprotective properties of GM1 in ischemic stroke, collected in the past two decades. We conclude that GM1 may have potential for stroke treatment, although we need to be …
Immunomodulation With Human Umbilical Cord Blood Stem Cells Ameliorates Ischemic Brain Injury – A Brain Transcriptome Profiling Analysis, Maple L. Shiao, Ce Yuan, Andrew T. Crane, Joseph P. Voth, Mario Juliano, Laura L. Hocum Stone, Zhenghong Nan, Ying Zhang, Nicole Kuzmin-Nichols, Paul R. Sanberg, Andrew W. Grande, Walter C. Low
Immunomodulation With Human Umbilical Cord Blood Stem Cells Ameliorates Ischemic Brain Injury – A Brain Transcriptome Profiling Analysis, Maple L. Shiao, Ce Yuan, Andrew T. Crane, Joseph P. Voth, Mario Juliano, Laura L. Hocum Stone, Zhenghong Nan, Ying Zhang, Nicole Kuzmin-Nichols, Paul R. Sanberg, Andrew W. Grande, Walter C. Low
Neurosurgery and Brain Repair Faculty Publications
Our group previously demonstrated that administration of a CD34-negative fraction of human non- hematopoietic umbilical cord blood stem cells (UCBSC) 48 h after ischemic injury could reduce infarct volume by 50% as well as significantly ameliorate neurological deficits. In the present study, we explored possible mechanisms of action using next generation RNA sequencing to analyze the brain transcriptome profiles in rats with ischemic brain injury following UCBSC therapy. Two days after ischemic injury, rats were treated with UCBSC. Five days after administration, total brain mRNA was then extracted for RNAseq analysis using Illumina Hiseq 2000. We found 275 genes that …
Men Lacking A Caregiver Have Greater Risk Of Long‐Term Nursing Home Placement After Stroke, Justin Blackburn, Karen C. Albright, William E. Haley, Virginia J. Howard, David L. Roth, Monika M. Safford, Meredith L. Kilgore
Men Lacking A Caregiver Have Greater Risk Of Long‐Term Nursing Home Placement After Stroke, Justin Blackburn, Karen C. Albright, William E. Haley, Virginia J. Howard, David L. Roth, Monika M. Safford, Meredith L. Kilgore
Aging Studies Faculty Publications
Background/Objectives: Social support can prevent or delay long‐term nursing home placement (NHP ). The purpose of our study was to understand how the availability of a caregiver can affect NHP after ischemic stroke and how this affects different subgroups differently.
Design: Nested cohort study.
Setting: Nationally based RE asons for Geographic and Racial Differences in Stroke (REGARDS ) study.
Participants: Stroke survivors aged 65 to 100 (256 men, 304 women).
Measurements: Data were from Medicare claims from January 2003 to December 2013 and REGARDS baseline interviews conducted from January 2003 to October 2007. Caregiver support was measured by asking, “If …
Progress And Updates In Stroke Research: Introduction To The Special Issue On Stroke, Yu Luo, John H. Zhang, Paul R. Sanberg, Samantha M. Portis
Progress And Updates In Stroke Research: Introduction To The Special Issue On Stroke, Yu Luo, John H. Zhang, Paul R. Sanberg, Samantha M. Portis
Neurosurgery and Brain Repair Faculty Publications
As guest editors of this special issue, we are delighted to present 13 articles that discuss advances in stroke research including translational stroke research, stroke research milestones, and proposals for future directions. Stroke is a major cause of disability, and, according to the Centers for Disease Control and Prevention, is the fifth leading cause of death in the US alone. Possible factors contributing to stroke pathogenesis are elucidated and possible treatment modalities are explored in the following special issue of Cell Transplantation.
Cost-Effectiveness Analysis Of Targeted Herpes Zoster Vaccination In Adults 50-59 At Increased Cardiovascular Risk, Kathleen M. Glassner
Cost-Effectiveness Analysis Of Targeted Herpes Zoster Vaccination In Adults 50-59 At Increased Cardiovascular Risk, Kathleen M. Glassner
USF Tampa Graduate Theses and Dissertations
Background: Over the last twenty years the incidence of herpes zoster (HZ) infection, also known as shingles, has been increasing among adults for unknown reasons. The economic burden of HZ is currently estimated at over $1 billion per year in the United States (U.S.) and is expected to increase as the susceptible adult population ages. HZ is caused by a re-activation of the varicella zoster virus (VZV), chicken pox, and more than 95% of adults living today carry the virus with a lifetime risk of 1 in 3 for developing HZ. In 2006 the FDA approved a vaccine for the …
Reorienting Health Services To People With Chronic Health Conditions: Diabetes And Stroke Services In Malaysia, Sri Lanka And Thailand, Vasoontara Yiengprugsawan, Judith Healy, Hal Kendig, Malinee Neelamegam, Palitha Karunapema, Vijj Kasemsup
Reorienting Health Services To People With Chronic Health Conditions: Diabetes And Stroke Services In Malaysia, Sri Lanka And Thailand, Vasoontara Yiengprugsawan, Judith Healy, Hal Kendig, Malinee Neelamegam, Palitha Karunapema, Vijj Kasemsup
Epidemiology and Biostatistics Faculty Publications
This paper explores whether middle-income Asian countries are reorienting their health services in response to non-communicable diseases (NCDs). Malaysia, Sri Lanka, and Thailand were selected as case studies of Asian societies experiencing rapid increases both in NCDs and an aging population. While NCD programs, especially those related to diabetes and stroke, are well-established in Thailand, health services struggle to respond to increasing numbers of people with chronic health problems. Health services at all levels must plan ahead for more patients with chronic and often multiple conditions who require better integrated health care.
Medicare Claims Indicators Of Healthcare Utilization Differences After Hospitalization For Ischemic Stroke: Race, Gender, And Caregiving Effects, David L. Roth, Orla C. Sheehan, Jin Huang, James D. Rhodes, Suzanne Judd, Meredith Kilgore, Brett Kissela, Janeet P. Bettger, William E. Haley
Medicare Claims Indicators Of Healthcare Utilization Differences After Hospitalization For Ischemic Stroke: Race, Gender, And Caregiving Effects, David L. Roth, Orla C. Sheehan, Jin Huang, James D. Rhodes, Suzanne Judd, Meredith Kilgore, Brett Kissela, Janeet P. Bettger, William E. Haley
Aging Studies Faculty Publications
Background—Differences in healthcare utilization after stroke may partly explain race or gender differences in stroke outcomes and identify factors that might reduce post-acute stroke care costs.
Aim—To examine systematic differences in Medicare claims for healthcare utilization after hospitalization for ischemic stroke in a United States (US) population-based sample.
Methods—Claims were examined over a 6-month period after hospitalization for 279 ischemic stroke survivors 65 years or older from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. Statistical analyses examined differences in post-acute healthcare utilization, adjusted for pre-stroke utilization, as a function of race (African American …
Leukemia Inhibitory Factor As A Neuroprotective Agent Against Focal Cerebral Ischemia, Stephanie Davis
Leukemia Inhibitory Factor As A Neuroprotective Agent Against Focal Cerebral Ischemia, Stephanie Davis
USF Tampa Graduate Theses and Dissertations
Previous publications from this laboratory demonstrated that administration of leukemia inhibitory factor (LIF) (125 µg/kg) to young, male Sprague-Dawley rats at 6, 24, and 48 h after middle cerebral artery occlusion (MCAO) reduced infract volume, improved sensimotor skills, and alleviated damage to white matter at 72 h after the injury. In vitro studies using cultured oligodendrocytes (OLs) showed that LIF (200 ng/ml) also protects against 24 h of oxygen-glucose deprivation through activation of Akt signaling and upregulation of the antioxidant enzymes peroxiredoxin IV and metallothionein III. Other groups have demonstrated that LIF reduces neurodegeneration in animal models of disease, but …
Sigma Receptor Activation Mitigates Toxicity Evoked By The Convergence Of Ischemia, Acidosis And Amyloid-Beta, Adam Alexander Behensky
Sigma Receptor Activation Mitigates Toxicity Evoked By The Convergence Of Ischemia, Acidosis And Amyloid-Beta, Adam Alexander Behensky
USF Tampa Graduate Theses and Dissertations
Stroke is the fifth leading cause of death in the United States and a major cause of long-term disability in industrialized countries. The core region of an ischemic stroke dies within minutes due to activation of necrotic pathways. Outside of this core region is the penumbral zone, where some perfusion is maintained via collateral arteries. Delayed cell death occurs in this area due to the triggering of apoptotic mechanisms, which expands the ischemic injury over time. The cellular and molecular events that produce the expansion of the ischemic core continue to be poorly understood. The increases in the amyloid precursor …
Secreted Factors From Human Umbilical Cord Blood Cells Protect Oligodendrocytes From Ischemic Insult, Derrick Rowe
Secreted Factors From Human Umbilical Cord Blood Cells Protect Oligodendrocytes From Ischemic Insult, Derrick Rowe
USF Tampa Graduate Theses and Dissertations
Oligodendrocytes (OL)s are the dominant cell type in the white matter and are integral for synaptic transmission essential for proper neuronal communication between brain areas. Previous studies have shown that intravenous administration of the mononuclear fraction of human umbilical cord blood (HUCB) cells in rat models of stroke reduced white matter injury, gray matter injury and behavioral deficits. Yet the mechanisms used by HUCB cells remain unknown in ischemic injury. These studies will investigate both in vitro and in vivo approaches to elucidate this mechanism in OLs. When mature primary OLs were coincubated with HUCB cells, HUCB cells secreted soluble …
Neuroprotection With Anesthetics In Two Models Of Cerebral Ischemia, Rafael Eduardo Chaparro Buitrago
Neuroprotection With Anesthetics In Two Models Of Cerebral Ischemia, Rafael Eduardo Chaparro Buitrago
USF Tampa Graduate Theses and Dissertations
Neuroprotection with anesthetics has been studied for many decades; important advances in this field have modified the way Anesthesiologists treat patients in the operating room. Animal models have played an important role in the study of ischemia in the operating room. Recent studies have demonstrated that the effect of anesthetics seems to be different in different animal models. We decided to evaluate anesthetics in a well-known model of cerebral ischemia and also in hypotensive models designed by us. We used a model of cerebral ischemia (MCAO) to test anesthetics neuroprotective effect in a two-week period. Then, we used a model …
Naming And Inhibition In Aphasia, Lori R. Bartels-Tobin
Naming And Inhibition In Aphasia, Lori R. Bartels-Tobin
USF Tampa Graduate Theses and Dissertations
Lexical retrieval models illustrate both activation and inhibition between concepts, words, and phonemes. When semantic activation spreads from one concept to its related concepts, inhibition is recruited so that competition between related concepts can be overcome and a target production achieved. Persons with aphasia often exhibit difficulty with producing the desired response, which could be the result of inadequate inhibitory processes to overcome response competition.
Inhibitory processing is typically measured using a negative priming task. Twenty participants with aphasia, twenty-five young participants, and twenty age-matched aphasia group controls were recruited for this study. Participants with aphasia completed a picture-naming task, …
Human Umbilical Cord Blood Cells Migration To Stroke Cns Tissue Extracts And The Potential Cytokines And Chemokines Involved, Mary B. Newman
Human Umbilical Cord Blood Cells Migration To Stroke Cns Tissue Extracts And The Potential Cytokines And Chemokines Involved, Mary B. Newman
USF Tampa Graduate Theses and Dissertations
Human umbilical cord blood (HUCB) cells consist of a heterogeneous population of cells, rich in hematopoietic stem and progenitor cells. These cells have been used in the treatment of various nonmalignant and malignant hematopoietic diseases. With in the last few years HUCB cells have been used in pre-clinical animal models of brain and spinal cord injuries, in which functional recovery has been shown. The properties of cord blood cells that could be important in cell transplantation (repair or replacement) of CNS injury or disease are currently being evaluated. The major focus of this study was to determine whether HUCB cells …
Evaluation Of The Prognostic Criteria For Medicare Hospice Eligibility, D Helen Moore
Evaluation Of The Prognostic Criteria For Medicare Hospice Eligibility, D Helen Moore
USF Tampa Graduate Theses and Dissertations
This work evaluates Medicare Hospice Benefit (MHB) eligibility standards that are referenced throughout this work as either "Medicare prognostic criteria," or "Local Medical Review Policies." Following the Chapter 1 overview of prognosis in end-stage disease, association between the Medicare clinical predictors and survival outcomes in dementing, cardiovascular and cerebrovascular illnesses are described in Chapter 2. Chapter 3 examines the prognostic belief systems of multidisciplinary hospice personnel. Chapter 4 seeks to improve the predictive performance of the Medicare prognostic criteria for dementia. The fifth and final chapter critiques the Medicare prognostic criteria from conceptual, methodological, and applied perspectives and suggests related …