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Compositions And Methods For Treating Rsv-Infections, Eleni Markoutsa, Subhra Mohapatra, Shyam Mohapatra
Compositions And Methods For Treating Rsv-Infections, Eleni Markoutsa, Subhra Mohapatra, Shyam Mohapatra
USF Patents
This invention provides for a RSV-targeted nanoparticle PMN (RTPMN), combining HR2D anti-fusion peptide, and plasmid encoded siRNA against RSV-NS1 and/or RSV-P gene as a safe, effective and inexpensive anti-RSV prophylaxis and/or therapy.
Method For Electroporation Controlled By Electrical Impedence Measurements, Mark Jeffrey Jaroszeski, Timothy Fawcett, Richard Jason Connolly, Andrew M. Hoff, Reginald Morley Atkins, Douglas Walter Brown, Richard A. Gilbert
Method For Electroporation Controlled By Electrical Impedence Measurements, Mark Jeffrey Jaroszeski, Timothy Fawcett, Richard Jason Connolly, Andrew M. Hoff, Reginald Morley Atkins, Douglas Walter Brown, Richard A. Gilbert
USF Patents
The present invention provides a system and method for measuring an impedance of one or more target cells before and after an electroporation protocol has been applied to the one or more target cells. The result of the impedance measurement provides a feedback control that can be implemented during and/or after the electroporation protocol to customize the electrical treatment for a particular target cell or cellular tissue.
Inhibition Of Beta-Arrestin Oligomerization In Tauopathy, Jung A. Woo, Stephen Bryant Liggett, David E. Kang, Yu Chen, Eric Lewandowski
Inhibition Of Beta-Arrestin Oligomerization In Tauopathy, Jung A. Woo, Stephen Bryant Liggett, David E. Kang, Yu Chen, Eric Lewandowski
USF Patents
As disclosed herein, β-arrestin1 and β-arrestin2 levels are highly elevated in brains of FTLD-tau patients suggesting that both β-arrestin1 and β-arrestin2 are elevated in the brains of patients with AD and FLTD. The current work also shows that when β-arrestin2 is overexpressed, tau levels become elevated. The data indicate that β-arrestin2 reduces tau clearance by impairing p62-mediated autophagy, a role carried out by the oligomerized form of β-arrestin2. Therefore, disclosed herein are β-arrestin oligomerization inhibitors that can be used to prevent β-arrestin oligomerization and therefore the accumulation of tau in cells, i.e. tauopathy. Also disclosed are methods of treating a …
Methods Of Treating Cognitive Impairment, Huntington Potter, Gary W. Arendash, Steven Bennett, Timothy Boyd
Methods Of Treating Cognitive Impairment, Huntington Potter, Gary W. Arendash, Steven Bennett, Timothy Boyd
USF Patents
The subject invention concerns materials and methods for treating a person or animal having cognitive impairment. In one embodiment, the method comprises administering an effective amount of one or more inflammatory mediator(s), for example, fms-related tyrosine kinase 3 (Flt3) ligand, interleukin-6 (IL-6), macrophage migration inhibitory factor (MIF), interleukin-1 (IL-1), interleukin-3 (IL-3), erythropoietin (EPO), vascular endothelial growth factor A (VEGF-A), hypoxia-inducible transcription factor (HIF-1alpha), insulin like growth factor-1 (IGF-1), tumor necrosis factor (TNF), granulocyte colony-stimulating factor (G-CSF), granulocyte/macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), Stem Cell Factor (SCF), Darbepoetin (ARANESP), and metalloproteinases, to an animal or person in need of …
4d-Perfused Tumoroid-On-A-Chip Platform For Personalized Cancer Treatment Applications, Subhra Mohapatra, Shyam S. Mohapatra, Tao Wang
4d-Perfused Tumoroid-On-A-Chip Platform For Personalized Cancer Treatment Applications, Subhra Mohapatra, Shyam S. Mohapatra, Tao Wang
USF Patents
A 4D-perfused tumoroid-on-a-chip platform used in personalized cancer treatment. The platform includes a plate with a plurality of bottomless wells that resides atop a microfluidic channel layer, which in turn resides atop a surface acoustic wave (SAW) based sensor layer that is capable of measuring potential pH values of fluids disposed within the platform. The microfluidic channel layer includes a plurality of bioreactors, with each bioreactor including an inlet well, a culture well, and an outlet well. The inlet well, culture well, and outlet well form a closed system via fluid conduits spanning from the inlet well to the culture …
Motion Taxonomy For Manipulation Embedding And Recognition, Yu Sun, David Andres Paulius, Maxat Alibayev
Motion Taxonomy For Manipulation Embedding And Recognition, Yu Sun, David Andres Paulius, Maxat Alibayev
USF Patents
A method for motion recognition and embedding is disclosed. The method may include receiving a plurality of frames of an input video for extracting a feature vector of a motion in the plurality of frames, generating a plurality of sets of one or more motion component bits based on the feature vector and a plurality of classifiers, the plurality of sets corresponding to the plurality of classifiers, each set of one or more motion component bits representing a physical or mechanical attribute of the motion; and generating a motion code for a machine to execute the motion by combining the …
Hybrid Electro-Plasmonic Modulation Of Neural Activity With Visible-Light-Sensitive Gold Nanotransducer Interface, Ratka Damnjanovic, Parveen Bazard, Robert Dana Frisina, Venkat Rama Bhethanabotla
Hybrid Electro-Plasmonic Modulation Of Neural Activity With Visible-Light-Sensitive Gold Nanotransducer Interface, Ratka Damnjanovic, Parveen Bazard, Robert Dana Frisina, Venkat Rama Bhethanabotla
USF Patents
A method of modulating neural activity using a combination of electrical and optical stimulation transmitted via a gold nanoparticle covered nanoelectrode is presented. The combination of short-duration green visible light optical pulses with the complementary sub-threshold level electric current pulses are capable of producing action potentials in neurons. Cells were found to have a greater than a 5Ã survival rate using this hybrid stimulation method as compared to pure plasmonic/optical stimulation. The cell stimulation success rate was 3Ã greater with hybrid stimulation.
Apkc Inhibitors And Methods Of Treating A Neurodegenerative Disease Or Disorder, Robert Vito Farese, Mini Paliyath Sajan, Margaret Genevieve Higgs
Apkc Inhibitors And Methods Of Treating A Neurodegenerative Disease Or Disorder, Robert Vito Farese, Mini Paliyath Sajan, Margaret Genevieve Higgs
USF Patents
Provided herein are formulations effective for and methods of treating or preventing a neurodegenerative disorder in a subject in need thereof that can include administering an amount of an aPKC inhibitor to a subject in need thereof.
Modulating Angiogenesis By Proteomimetics Of Vascular Endothelial Growth Factor, Jianfeng Cai, Sami Abdulkadir
Modulating Angiogenesis By Proteomimetics Of Vascular Endothelial Growth Factor, Jianfeng Cai, Sami Abdulkadir
USF Patents
Provided herein are novel VEGF mimics, pharmaceutical compositions thereof, and methods of their use in increasing or reducing angiogenesis.
Self-Replicating Cell Selective Gene Delivery Compositions, Methods, And Uses Thereof, Hana Totary-Jain
Self-Replicating Cell Selective Gene Delivery Compositions, Methods, And Uses Thereof, Hana Totary-Jain
USF Patents
Described herein are cell-selective mRNA constructs that can contain a RNA of interest and one or more miRNA targets. The cell-selective mRNA constructs described herein can be used to express an RNA of interest to a cell in a cell-selective manner.
Nanoparticles Carrying Antibiotics, Edward Turos, Faeez Mahzamani
Nanoparticles Carrying Antibiotics, Edward Turos, Faeez Mahzamani
USF Patents
The subject invention pertains to polyacrylate homopolymers produced from acrylolated drug monomers. The homopolymers can be produced in the form of nanoparticles. The nanoparticles comprising the homopolymers can be produced via a free radical-induced emulsion polymerization of the acrylolated drug monomers to produce an aqueous emulsion of uniformly sized nanoparticles. The homopolymers of the invention containing acrylolated antibiotic monomers can be active against Gram-positive and Gram-negative bacteria, such as Staphylococcus aureus and Escherichia coli. Accordingly, methods are provided of treating a disease, for example, an infection, by administering to a subject the homopolymers, homopolymeric nanoparticles, or emulsions containing homopolymeric nanoparticles …
Methods For Achieving A Target Joint Preload, Daniel P. Hess
Methods For Achieving A Target Joint Preload, Daniel P. Hess
USF Patents
A method for achieving a target joint preload includes identifying a thread pitch of a first fastener element used to secure two components together. The first fastener element is passed through the two components and a second fastener element is threaded onto the first fastener element. A tightening torque is applied to the second fastener element, which is measured as the trial tightening torque. A loosening torque is applied to the second fastener element, which is measured as the trial removal torque. A required tightening torque that is required to be applied to the second fastener element to achieve the …
Sr Flip-Flop Based Physical Unclonable Functions For Hardware Security, Srinivas Katkoori, Rohith Prasad Challa, Sheikh Ariful Islam
Sr Flip-Flop Based Physical Unclonable Functions For Hardware Security, Srinivas Katkoori, Rohith Prasad Challa, Sheikh Ariful Islam
USF Patents
The present disclosure presents various systems and methods for implementing a physical unclonable function device. One such method comprises providing an integrated circuit having a plurality of set/reset flip flop logic circuits, wherein each of the set/reset flip flop logic circuits enters a metastable state for a particular input sequence. The method includes varying circuit parameters for each of the plurality of set/reset flip flop logic circuits to account for manufacturing variations in the set/reset flip flop logic circuits and enable generating a stable but random output in response to the particular input sequence. Thus, by applying the particular input …
Bone Fusion System, Frank D. Vrionis, Kamran Aghayev, Sabrina A. Gonzalez Blohm, James J. Doulgeris
Bone Fusion System, Frank D. Vrionis, Kamran Aghayev, Sabrina A. Gonzalez Blohm, James J. Doulgeris
USF Patents
A method and system for performing bone fusion and/or securing one or more bones, such as adjacent vertebra, are disclosed. The screws include a threaded tip connected to a main shaft and a threaded outer sleeve that rotates relative to the outer shaft until locked down. Independent rotation of the threaded outer sleeve relative to the threaded distal tip allows compression or distraction to modify the gap between the vertebral bodies. The screws are passed from the inferior to superior vertebra or superior to inferior, for example, through a trans-pedicular route to avoid neurological compromise. At the same time, the …
Protection Of Polymeric/Organic Materials From Photodegradation By Encapsulation, Elias K. Stefanakos, Sesha S. Srinivasan
Protection Of Polymeric/Organic Materials From Photodegradation By Encapsulation, Elias K. Stefanakos, Sesha S. Srinivasan
USF Patents
Structures of a particle containing a core and at least one shell, a metal oxide material of which is necessarily doped to ensure protection of a material of the core from photodegradation. The core can include any of a thermochromic material, a phase-change material, and a judiciously defined auxiliary material that in turn contains organic and/or polymeric material. Derivative products utilizing a plurality of such particles. Methodologies for producing such particles and derivative products.
N-Myc-Interactor Protein As A Marker For Chronic Lung Disease And Uses Thereof, Nirmal S. Sharma, Mudassir Banday, Andreas Seyfang
N-Myc-Interactor Protein As A Marker For Chronic Lung Disease And Uses Thereof, Nirmal S. Sharma, Mudassir Banday, Andreas Seyfang
USF Patents
A method of predicting the development of chronic lung allograft dysfunction (CLAD) in lung transplant patients using N-myc-interactor (NMI) as a biomarker and associated treatment thereof is presented. Also presented is a method of reducing the risk of CLAD by administering a therapeutic agent capable of increasing NMI in the patient. NMI is a critical regulator of epithelial-to-mesenchymal transition (EMT) and an important precursor to development of CLAD. NMI expression is reduced in CLAD patients and can be used as an early diagnostic biomarker to predict the development of CLAD. NMI can also be used as a drug target for …
Pkc-Delta-I Inhibitor Formulations And Uses Thereof, Niketa A. Patel, Rekha S. Patel, Robert Pleasants Sparks, Wayne Charles Guida
Pkc-Delta-I Inhibitor Formulations And Uses Thereof, Niketa A. Patel, Rekha S. Patel, Robert Pleasants Sparks, Wayne Charles Guida
USF Patents
Provided herein are formulations that can contain an effective amount of a PKCδ inhibitor. Also provided herein are methods of inhibiting a PKCδ in a subject in need thereof, that can include the step of administering an effective amount of a compound that is capable of inhibiting a PKCδ.
Strategy To Increase Anti-Viral, Anti-Microbial, And Anti-Fungal Defense, Hana Totary-Jain
Strategy To Increase Anti-Viral, Anti-Microbial, And Anti-Fungal Defense, Hana Totary-Jain
USF Patents
Disclosed herein are compositions and methods for inducing, promoting, or enhancing an immune response in a subject. For example, the disclosed compositions and methods can be used prophylactically to prevent viral/microbial infections or therapeutically to treat acute infections. In some embodiments, the disclosed method involves administering to the subject a composition comprising in vitro transcribed (IVT) RNA comprising short interspersed nuclear elements (SINEs), such as Alu repeats. In some embodiments, the disclosed compositions and methods can be used to induce, promote, or enhance any immune response in a subject, including an anti-viral, anti-microbial, anti-fungal, or anti-parasite response. In some embodiments, …
Plasmonic Photoelectrochemical Oxidation Face Mask, Dharendra Yogi Goswami, Dilip Neeraj Goswami
Plasmonic Photoelectrochemical Oxidation Face Mask, Dharendra Yogi Goswami, Dilip Neeraj Goswami
USF Patents
A breathing system for removing harmful contaminants, such as microbes and volatile organic compounds, is provided. The breathing system includes a face mask, an inhalation limb, and a plasmonic device. As a contaminated gas flows through an internal chamber of the plasmonic device, the contaminates are oxidized. Specifically, the internal chamber includes a source of photons spaced apart from the nanostructure. The nanostructure is coated in a plasmonic layer, including noble metal nanoparticles. The plasmonic layer is protected from oxidation through a photocatalyst layer disposed thereon.
Integrated Detection Scheme For Fast Blood Flow Measurement, Ashwin Bharadwaj Parthasarathy, Arindam Biswas, Arash Takshi
Integrated Detection Scheme For Fast Blood Flow Measurement, Ashwin Bharadwaj Parthasarathy, Arindam Biswas, Arash Takshi
USF Patents
Disclosed are various embodiments for integrated diffuse correlation spectroscopy. A first control signal can be sent to a switch to cause an integrator to integrate a current from a photodiode. An integrated current can be received from the integrator, and a data signal can be sent to a computing device based at least in part on the integrated current. A second control signal can be sent to a switch to cause the integrator to cease integrating the current from the photodiode.
Systems And Methods For Generating Tactile 3d Maps, Howard David Kaplan, Spenser Fox Mason
Systems And Methods For Generating Tactile 3d Maps, Howard David Kaplan, Spenser Fox Mason
USF Patents
A method for generating three dimensional indicators for the visually impaired. The method includes selecting one or more pre-designed symbols from a plurality of pre-designed symbols. The pre-designed symbols represent standard building layout features and are sized to be readable via a physical touch. The method further includes inserting the one or more selected symbols into a two dimensional digital layout, and generating one or more of an orientation object and a legend object into the two dimensional digital layout. The method further includes converting the two dimensional digital layout into a three dimensional digital model, and generating an output …
Acoustic Resonator, Wen-Qing Xu, Di Lan, Jing Wang, Weiqi Li, Xu Han, Chao Liu, Elgin Eissler, Giovanni Barbarossa
Acoustic Resonator, Wen-Qing Xu, Di Lan, Jing Wang, Weiqi Li, Xu Han, Chao Liu, Elgin Eissler, Giovanni Barbarossa
USF Patents
An acoustic resonator includes a piezoelectric stack including a piezoelectric layer having a top surface and a bottom surface, a top electrode layer disposed above the top surface, and a bottom electrode layer disposed below the bottom surface. A number of acoustic wave reflectors are disposed on a side of the bottom electrode layer opposite the piezoelectric layer. Each acoustic wave reflector includes a high acoustic impedance layer and may include a low acoustic impedance layer. The acoustic resonator may include a tether that extends laterally to a stacking direction of the layers of the piezoelectric stack. A supporting structure …
Substituted Chromenones, Ire1 Inhibitors, And Methods Of Using Same, Chih-Chi Andrew Hu, Juan R. Del Valle
Substituted Chromenones, Ire1 Inhibitors, And Methods Of Using Same, Chih-Chi Andrew Hu, Juan R. Del Valle
USF Patents
The present invention includes substituted chromenones that are useful to inhibit the IRE1/XBP-1 pathway. In certain embodiments, the compounds of the invention inhibit IRE1's RNase activity. In other embodiments, the compounds of the invention are useful to treat or prevent a cancer that involve activation of the ER stress response. The invention also relates, in certain aspects, to the discovery that secretory IgM (sIgM) can orchestrate an immunosuppressive microenvironment by recruiting myeloid-derived suppressor cells (MDSCs) into different tumor models, such as but not limited to solid tumors (such as but not limited to lung cancer) and tumors that have high …
Thermal Rectifying Antenna Complex (Trac), Michael Wayne Fountain, Gabriel Lee Saffold
Thermal Rectifying Antenna Complex (Trac), Michael Wayne Fountain, Gabriel Lee Saffold
USF Patents
A method and device to collect and convert thermal energy from the surrounding environments to produce usable electric power. The device includes a rectenna that is preferably a narrow bandwidth rectenna. In an embodiment, the rectenna comprises a rectenna complex, which is, in sequence, a high gain antenna, optional matching circuits, an optional narrow bandpass filter, and one or more rectifying diodes. An embodiment may include multiple arrays of linked nanoscale rectenna complexes. When linked in arrays using preselected bandwidths in the infrared and near infrared spectral regions, the rectenna complex acts as a thermally responsive collector capable of extracting …
Portable Orthogonal Surface Acoustic Wave Sensor System For Simultaneous Sensing, Removal Of Nonspecifically Bound Proteins And Mixing, Venkat R. Bhethanabotla, Shuangming Li
Portable Orthogonal Surface Acoustic Wave Sensor System For Simultaneous Sensing, Removal Of Nonspecifically Bound Proteins And Mixing, Venkat R. Bhethanabotla, Shuangming Li
USF Patents
Disclose herein is a portable platform based on a direct digital synthesizer (DDS) is investigated for the orthogonal SAW sensor, integrating signal synthesis, gain control, phase/amplitude measurement, and data processing in a small, portable electronic system. The disclosed platform allows for simultaneous removal of non-specific binding proteins, and mixing, as well as improved incubation time.
Small Molecule Inhibitors Targeting Clostridioides Difficile Sporulation, Yu Chen, Michael Sacco, James Leahy, Elena Bray, Xingmin Sun, Xiujun Zhang
Small Molecule Inhibitors Targeting Clostridioides Difficile Sporulation, Yu Chen, Michael Sacco, James Leahy, Elena Bray, Xingmin Sun, Xiujun Zhang
USF Patents
Disclosed herein are compounds that can prevent and treat C. difficile by inhibiting sporulation. Also disclosed herein are compositions and formulations comprising the compound disclosed herein. Methods of preventing and treating C. difficile comprising administering the compounds described herein are also disclosed.
Single Active Layer Electrochromic Devices, Manoj Kumar Ram, Elias K. Stefanakos
Single Active Layer Electrochromic Devices, Manoj Kumar Ram, Elias K. Stefanakos
USF Patents
In one embodiment, an electrochromic device includes a single active layer configured to be alternately placed in a light-transmitting state in which relatively large amounts of light can be transmitted through the active layer and a light-blocking state in which relatively small amounts of light can be transmitted through the active layer, wherein the device comprises no other layers of material that contribute to transitioning between the two states.
System And Medication Box For Improving Medication Adherence, William Diehl Kearns, Kimberly Ann Crosland, Jeffrey D. Craighead, James Leonard Fozard
System And Medication Box For Improving Medication Adherence, William Diehl Kearns, Kimberly Ann Crosland, Jeffrey D. Craighead, James Leonard Fozard
USF Patents
A medication adherence system and corresponding medication box for improving medication adherence. The system includes the medication box, which is transparent and has a machine-readable marker, such as a QR code, on or beneath the floor thereof. The marker is capable of being scanned and read through the transparent bottoms of individual chambers. Data embedded in the marker includes, but is not limited to, the user's medication plan, the date and time when the medication is to be ingested, and instructions for recording the date and time when the marker is scanned and read. The underlying software program/application processes this …
Metabolic Therapy For Wound Healing, Dominic Paul D'Agostino, Shannon Kesl
Metabolic Therapy For Wound Healing, Dominic Paul D'Agostino, Shannon Kesl
USF Patents
Ketone supplementation, such as through use of precursors of beta-hydroxybutyrate (BHB) and acetoacetate (AcAc), increased blood levels of ketone bodies, increases blood flow and wound closure in ischemic young and aged fisher rats significantly earlier compared to standard diet in aged rats. In vitro experiments with ketone bodies demonstrate decreased mitochondrial and cytosolic ROS in young and aged primary human dermal fibroblasts (PHDF). Ketone bodies increased migration in young and aged PHDFs.
Compositions And Uses Thereof For Treatment Of Idiopathic Preterm Birth, Charles Lockwood, Ozlem Guzeloglu-Kayisli, Umit Ali Kayisli, Frederick Schatz
Compositions And Uses Thereof For Treatment Of Idiopathic Preterm Birth, Charles Lockwood, Ozlem Guzeloglu-Kayisli, Umit Ali Kayisli, Frederick Schatz
USF Patents
Disclosed are compositions and methods for delaying or preventing idiopathic preterm birth.