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Immunological Characteristics In Refractory Chronic Rhinosinusitis With Nasal Polyps Undergoing Revision Surgeries, Gwanghui X Gwanghui Ryu, Dong-Kyu Kim, Hun-Jong Dhong, Kyoung Mi Eun, Seung-Kyu Chung, Dong-Young Kim, Chae-Seo Rhee, Seong-Ho Cho, Sang Duk Hong, Dae Woo Kim
Immunological Characteristics In Refractory Chronic Rhinosinusitis With Nasal Polyps Undergoing Revision Surgeries, Gwanghui X Gwanghui Ryu, Dong-Kyu Kim, Hun-Jong Dhong, Kyoung Mi Eun, Seung-Kyu Chung, Dong-Young Kim, Chae-Seo Rhee, Seong-Ho Cho, Sang Duk Hong, Dae Woo Kim
Internal Medicine Faculty Publications
Purpose: Despite medical and surgical treatments, some cases of nasal polyps (NP) exhibit recidivism. However, the endotype of refractory chronic rhinosinusitis with NP (CRSwNP) remains unclear. Therefore, the objective of this study was to characterize the immunological profile of refractory CRSwNP. Methods: The control (n =23), primary NP group (pNP, n =70) and refractory NP group (rNP, n =86) were enrolled in this study. Patients who underwent revision surgeries due to failed maximal medical treatment after primary surgery were defined as the rNP group. A total of 18 inflammatory markers were investigated in nasal tissues using multiplex cytokine assay or …