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Stimulating Canonical Wnt Signaling In Pituitary Progenitors Inhibits Differentiation Of Hormone Cell Types, Tanner F. Coleman
Stimulating Canonical Wnt Signaling In Pituitary Progenitors Inhibits Differentiation Of Hormone Cell Types, Tanner F. Coleman
Senior Theses
The mouse pituitary gland secretes hormones that regulate many physiological processes including growth, stress response, and reproduction. The canonical WNT signaling pathway, activation of which results in nuclear accumulation of β-CATENIN and transcription of target genes including LEF1, is crucial for proper development of the pituitary gland. Pituitary progenitors that lack β-CATENIN at embryonic day of development 8.5 (E8.5) cannot form three of the six cell types of the anterior pituitary that produce growth hormone (GH), thyroid stimulating hormone (TSH), and prolactin (PRL). Additionally, stimulating canonical WNT signaling through creation of degradation-resistant β-CATENIN at E9.5 causes pituitary tumors and results …
Exploring The Role Of Schema Development And Its Impact Within The Digital Vocabulary Application Quizlet, Jana M. Tolleson
Exploring The Role Of Schema Development And Its Impact Within The Digital Vocabulary Application Quizlet, Jana M. Tolleson
Theses and Dissertations
The purpose of this action research study was to ascertain the possible impact of using schema development strategies and the digital application Quizlet on student learning perspectives and achievement in a mid-level social studies classroom. U.S. schools are highly influenced by state standardized testing based on standards-driven curriculum that reinforces basic recall and recognition. School curriculum should be focused on higherlevel thinking skills such as critical thinking, social negotiation, and self-directed learning. The identified problem of practice of this study explored and described the use of technology at a basic level. Students are exploiting technology by copying and pasting information …
More Than Meets The Eye: Development Of A Sport Event Stimuli And Destination Image Fit Scale, Yongjin Hwang
More Than Meets The Eye: Development Of A Sport Event Stimuli And Destination Image Fit Scale, Yongjin Hwang
Theses and Dissertations
Much research demonstrates an impact of sensory experience on sports fans’ satisfaction with live sporting events (Lee, Heere, & Chung, 2013; Lee, Lee, Seo, & Green, 2012). It was, however, not studied how to enhance those sense-centric experiences. One possible approach would be to utilize unique region-based characteristics to design unforgettable and emotionally engaging experiences. Most sporting events are location-based, and venues are also considered as a landmark of the area where they are placed. Consequently, we can create a natural link between sporting events and the hosting cities or regions. Visual designs, musical contents, famous local food, and signature …
The Impact Of Number Talks On Third-Grade Students’ Number Sense Development And Mathematical Proficiency, Nicole D. Gaillard
The Impact Of Number Talks On Third-Grade Students’ Number Sense Development And Mathematical Proficiency, Nicole D. Gaillard
Theses and Dissertations
This action research study employed a mixed-methods design to examine the impact of a number talks intervention on the number sense development and mathematical proficiency of students in one third-grade mathematics class. The number talks strategy was also studied to determine its impact on third-grade students’ development of a productive mathematical disposition. Number sense is “a person’s general understanding of numbers and operations along with the ability and inclination to use this understanding in flexible ways to make mathematical judgments and to develop useful strategies for handling numbers and operations” (McIntosh, Reys, & Reys, 1992, p. 3). This eight-week study …
Effect Of Resveratrol On The Development Of Eczema, Christopher Carlucci
Effect Of Resveratrol On The Development Of Eczema, Christopher Carlucci
Theses and Dissertations
Atopic dermatitis is a type of eczema characterized by chronic inflammation of the skin, affecting millions of people worldwide. Resveratrol, a naturally occurring stilbenoid, is widely believed to exhibit beneficial effects on a host of chronic diseases. Although some previous studies have aimed to evaluate the effects of resveratrol on the pathogenesis of atopic dermatitis, this relationship remains ill-defined. We have previously established that mast cell activation, remodeling, and cellular infiltration in the hypodermis all begin prior to the IgE-mediated immune response in an atopic dermatitis mouse model, and that this early pathogenesis is directly related to an increase in …
Development Of A High-Resolution Spatial Heterodyne Libs Spectrometer, Kevin A. Dudley
Development Of A High-Resolution Spatial Heterodyne Libs Spectrometer, Kevin A. Dudley
Theses and Dissertations
Laser-Induced Breakdown Spectroscopy (LIBS) is an atomic emission technique that uses a pulse laser to ablate a sample and form a plasma. Atomic emissions from the plasma provide unique elemental characteristics regarding the composition of the sample. The technique produces valuable qualitative results, but the accuracy of quantitative analyses is hindered by spectral line broadening mechanisms and laser pulse reproducibility, among other factors. The Spatial Heterodyne Spectrometer (SHS) is a high-resolution spectrometer with very high light throughput, and its use to LIBS is currently limited to two peer-reviewed publications. In the following work a high resolution SHS is developed and …
Development Of Models And Solution Methods For Different Drayage Applications, Samaneh Shiri
Development Of Models And Solution Methods For Different Drayage Applications, Samaneh Shiri
Theses and Dissertations
In the last decades, intermodal freight transport is becoming more attractive in the global supply chains and freight transport policy makings. Intermodal freight transport provides a cost-effective, reliable, and efficient movement of freight by utilizing the strengths of different transport modes. The initial and final segment of intermodal freight transport, performed by truck, is known as “drayage.” The scheduling of truck movements in drayage operation within the service area of an intermodal terminal is an operational problem which leads to a truck scheduling problem that determines the efficient schedule of trucks while satisfying all transportation demands and constraints. Drayage accounts …
The Design, Development, And Evaluation Of A Usable And Privacy-Enhanced Telepresence Interface For Older Adults, Xian Wu
Theses and Dissertations
Maintaining health and wellness while aging-in-place independently is crucial for older adults. Telepresence technology can be potentially beneficial for this target population to stay socially connected. However, this technology is not specifically designed for older adults. For this target population to adopt such technology successfully, it is important to ensure that they do not experience usability barriers. This research uses HCI/HRI concepts and technology design principles for older adults to design, develop and test telepresence user interfaces (UI). This addresses the following research questions: 1): What are the essential usability and privacy-enhanced features needed to inform the design and development …
Development Of Bimetallic Catalysts For Dry Reforming Of Methane And Hydrogenation Of Succinic Acid, Jayson Michael Keels
Development Of Bimetallic Catalysts For Dry Reforming Of Methane And Hydrogenation Of Succinic Acid, Jayson Michael Keels
Theses and Dissertations
Advances in natural gas recovery have greatly impacted the global economy; the abundant supply of gas has revealed new opportunities and challenges in a wide range of markets within the fuels and chemicals industries. One such opportunity exists with the overabundance of gas from remote wells that is flared or emitted because of the high costs associated with transportation of a chemical with such a high molar volume. A possible solution is an on-site process to convert gas to higher value chemicals that are liquid at standard conditions, and can more easily be transported. As a first step, CO2 from …
Development Of A Supplier’S Delivery Time And Delivered Quality Performance Index And Assessment Of Alternative Decisions Regarding Underperforming Suppliers For The Aerospace Industry, Clint Saidy
Theses and Dissertations
This study investigates current practices of supplier’s delivery assessment so that a comprehensive index and a cost function model could be properly developed. Following a thorough literature review, a framework was created based on a penalty cost function that integrates both suppliers’ ability to deliver on time, as well as suppliers’ capability to deliver good quality. Afterward, suppliers could then be ranked and placed either in good standing, or transversely on probation. Underperforming suppliers face three potential outcomes based on current literature: (1) switching supplier, (2) increase collaboration, (3) maintaining the status quo. The decision vis-à-vis failing suppliers is based …