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University of Richmond

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1999

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Modifications Of Nitric Oxide And Sexual Behavior In Prenatally Stressed Male Rats, Stephen D. Miller Aug 1999

Modifications Of Nitric Oxide And Sexual Behavior In Prenatally Stressed Male Rats, Stephen D. Miller

Master's Theses

Normal male sexual differentiation is the culmination of perfectly timed, prenatal gonadal hormone release. Prenatal stress (PS) has a detrimental effect upon this process, obstructing the natural development of brain structures and sexual behavior. Prenatally-stressed male rats exhibit many physiological and neuroendocrinological differences when compared to control males. PS has a particularly harmful effect upon male sexual behavior, to which the neurotransmitter nitric oxide (NO) has been shown to be intimately involved. The present experiment examined whether PS reduces nNOS, the rate limiting enzyme of NO, in the medial preoptic area (rnPOA) of male rats, and whether administration of the ...