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Mmtv-Pymt And Derived Met-1 Mouse Mammary Tumor Cells As Models For Studying The Role Of The Androgen Receptor In Triple-Negative Breast Cancer Progression, Jessica L. Christenson, Kiel T. Butterfield, Nicole S. Spoelstra, John D. Norris, Jatinder S. Josan, Julie A. Pollock, Donald P. Mcdonnell, Benita S. Katzenellenbogen, John A. Katzenellenbogen, Jennifer K. Richer
Mmtv-Pymt And Derived Met-1 Mouse Mammary Tumor Cells As Models For Studying The Role Of The Androgen Receptor In Triple-Negative Breast Cancer Progression, Jessica L. Christenson, Kiel T. Butterfield, Nicole S. Spoelstra, John D. Norris, Jatinder S. Josan, Julie A. Pollock, Donald P. Mcdonnell, Benita S. Katzenellenbogen, John A. Katzenellenbogen, Jennifer K. Richer
Chemistry Faculty Publications
Triple-negative breast cancer (TNBC) has a faster rate of metastasis compared to other breast cancer subtypes and no effective targeted therapies are currently FDA-approved. Recent data indicate that the androgen receptor (AR) promotes tumor survival and may serve as a potential therapeutic target in TNBC. Studies of AR in disease progression and the systemic effects of anti-androgens have been hindered by the lack of an AR-positive (AR+) immunocompetent preclinical model. In this study we identified the transgenic MMTV-PyMT (mouse mammary tumor virus-polyoma middle tumor antigen) mouse mammary gland carcinoma model of breast cancer and Met-1 cells derived from this model …