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Generating A Novel Fly Line To Quantify Cellular Oxidative Stress On Developing Drosophila Melanogaster, Hanna Washburn
Generating A Novel Fly Line To Quantify Cellular Oxidative Stress On Developing Drosophila Melanogaster, Hanna Washburn
Summer Research
The redox condition of the cell, the ratio of reactive oxygen species to reducing agents present, can indicate the likelihood of oncogenesis. There are several genetic pathways present, such as the Nrf2 pathway in humans, which moderate the level of reactive oxygen species (ROS) within the cell. The Nrf2 pathway is an orthologue to the cncC pathway in Drosophila melanogaster, making Drosophila an ideal model organism to study redox pathways in the cell. Previous work has shown that cncC alterations can alter oncogene levels in Drosophila, however it hasn’t been shown that this manipulation truly alters ROS levels within the …