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Effects Of Creatine Monohydrate Supplementation On Cytochrome C And Caspase-9 Expression In Skeletal Muscles From Doxorubicin Treated Rats, Yeon Hee Kim
Master's Theses
Doxorubicin (DOX) is an effective chemotherapeutic drug for many types of cancer. However, the deleterious effect of DOX is also observed in heart and skeletal muscles. Doxorubicin-induced reactive oxygen species (ROS) in mitochondria causes muscle dysfunction and atrophy leading to the release of cytochrome c (cyt c) and activation of caspase-9 (casp-9) which cause apoptosis, a programmed cell death in skeletal muscles. Previous studies have proposed that creatine (Cr) possesses antioxidant capacity by reducing ROS in oxidative environment. Creatine supplements have shown to reduce mitochondrial ROS production and decrease apoptotic enzyme activities in oxidative skeletal muscles; however, Cr’s effects on …
Comparison Of Gait Kinematic And Temporospatial Measures Between Lock And Pin And A New Vacuum Suspension System In Transtibial Amputees, Vanessa A. Kellems
Comparison Of Gait Kinematic And Temporospatial Measures Between Lock And Pin And A New Vacuum Suspension System In Transtibial Amputees, Vanessa A. Kellems
Master's Theses
Walking in healthy populations has been characterized by symmetrical gait patterns and used to determine variability within pathological populations. Gait patterns of individuals with transtibial amputation are commonly asymmetrical due to the inability to completely replicate the physiological ankle with prosthetics; thus, contributing to inter-limb asymmetries. Currently, only a few studies have reported the effects of suspension systems on gait mechanics. In this study, functional differences between lock and pin (PIN) and a newly developed internal vacuum suspension system (Smart PUCKTM) (PUCK) during overground and treadmill walking were evaluated in five transtibial amputees. Statistically, no differences were found between groups …
The Effects Of Combined Curcumin Supplementation And High Intensity Interval Training On Time Trial Performance In Moderately Active Individuals, Nora Jacqueline Johnston
The Effects Of Combined Curcumin Supplementation And High Intensity Interval Training On Time Trial Performance In Moderately Active Individuals, Nora Jacqueline Johnston
Master's Theses
Individuals who participate in intensified training programs such as high intensity interval training (HIIT), are at risk for an uncontrolled inflammatory response, which may hinder the body’s recovery process. Curcumin is the most recognized compound in turmeric and has a distinctive yellow color. Curcumin has many medicinal actions and is most well-known for its anti-inflammatory activities. More recently, curcumin has emerged as an agent that can potentially optimize performance during intense exercise and may also attenuate pain and muscle soreness. Additionally, curcumin has been linked to improvements in mental health status such as reductions in depression and anxiety. PURPOSE: The …
Comparison Of Socket Suspension Systems During Stair Ascent In Individuals With Transtibial Amputees, Gabrielle Marie Rentuma
Comparison Of Socket Suspension Systems During Stair Ascent In Individuals With Transtibial Amputees, Gabrielle Marie Rentuma
Master's Theses
Socket suspension systems have an important role in an amputee’s ability to perform activities of daily living. There are three common modes of suspension used to attach the prosthetic foot to the residual limb including lock and pin (PIN), suction, and vacuum suspension systems. A new vacuum suspension system has been developed, the PUCK, which has a vacuum system internal to the socket and maintains pressure throughout the residual limb. Previous literature has focused on the role of suspension during over-ground walking but few have examined the effects during a more difficult task such as stair ascent. The purpose of …
Effects Of Creatine Supplementation And Doxorubicin Treatment Of Myostatin And Muscle Ring-Finger Protein-1 Expression In The Rat Diaphragm, Addison M. Shepard
Effects Of Creatine Supplementation And Doxorubicin Treatment Of Myostatin And Muscle Ring-Finger Protein-1 Expression In The Rat Diaphragm, Addison M. Shepard
Master's Theses
Doxorubicin (DOX) is a highly potent chemotherapy drug that impacts the entire body rather than a targeted treatment area. While DOX treatment assists in the disruption and prevention of certain types of cancer growth, it damages many physiological processes in the body that were functioning normally and otherwise healthy prior to its administration. Damage induced by DOX on organ functioning can lead to other malignancies in the body, such as cachexia, cardiotoxicity, and myotoxicity, among others. Skeletal muscle relies on myogenic regulatory factors (MRFs), transcription factors expressed by satellite cells, for positive regulation of phases of muscle development and response …
The Impact Of Shod Versus Unshod Walking On Center Of Pressure Variability, Zachary Barrons
The Impact Of Shod Versus Unshod Walking On Center Of Pressure Variability, Zachary Barrons
Master's Theses
The purpose of the present investigation was to examine the influence of footwear on walking stability. Twenty healthy women walked at 1.3 m/s on an instrumented treadmill. One hundred steps (50-right, 50-left) were analyzed from two walking conditions (shod, unshod). The variability of the center of pressure (COP) for each step was calculated for quadrants of the contact period. Significant differences in variability were seen between shod and unshod conditions in all quadrants as well as differences between left and right feet in quadrants one and four. Restricted foot motion while shod may explain the differences seen in COP variability. …
Effects Of Exercise Training On The Blood Lactate Response To Acute Exercise In Cancer Survivors, Arjun Ramani
Effects Of Exercise Training On The Blood Lactate Response To Acute Exercise In Cancer Survivors, Arjun Ramani
Master's Theses
Otto Warburg, a German physiologist, deduced that cancer cells exhibit a remarkably different metabolic profile in comparison to normal healthy cells characterized by increased rates of glycolysis and lactate fermentation, even in the presence of adequate oxygen content. Through the respective gain of function/loss of function of oncogenes and tumor suppressor genes, three major genes emerge as hallmarks of carcinogenic metabolic reconfiguration; HIF-1a, c-Myc oncogenes, and p53 tumor-suppressor genes. A result of their respective gain/loss of function are the upregulation of several glycolytic proteins and subsequent high rates of glucose influx into the tumor microenvironment, as well as lactate production, …