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Alterations In Resting State Functional Connectivity Associated With Alcohol Use Severity And Impulsivity In A Community Sample, Elena R. Stein

Psychology ETDs

Alcohol Use Disorder (AUD) is characterized by neurocognitive and behavioral impairments including the multidimensional construct of impulsivity. Increased impulsivity is both a risk factor for, and a consequence of problematic alcohol use. Individuals with AUD exhibit alterations in neural circuitry when compared to those who do not have AUD. These circuit-level changes in AUD may underlie the difficulties that these individuals experience with heightened impulsivity. The present study uses data-driven resting state functional connectivity (rsFC) methodology to examine the differences in intrinsic functional networks between individuals with AUD and those who are social drinkers (SD). Participants in this secondary data …

Frameworks To Investigate Robustness And Disease Characterization/Prediction Utility Of Time-Varying Functional Connectivity State Profiles Of The Human Brain At Rest, Anees Abrol

Electrical and Computer Engineering ETDs

Neuroimaging technologies aim at delineating the highly complex structural and functional organization of the human brain. In recent years, several unimodal as well as multimodal analyses of structural MRI (sMRI) and functional MRI (fMRI) neuroimaging modalities, leveraging advanced signal processing and machine learning based feature extraction algorithms, have opened new avenues in diagnosis of complex brain syndromes and neurocognitive disorders. Generically regarding these neuroimaging modalities as filtered, complimentary insights of brain’s anatomical and functional organization, multimodal data fusion efforts could enable more comprehensive mapping of brain structure and function.

Large scale functional organization of the brain is often studied by …

The Effects Of Prenatal Alcohol Exposure On The Resting State Functional Brain Connectivity In A Sample Of Individuals With Fetal Alcohol Spectrum Disorder, Carlos I. Rodriguez

Psychology ETDs

It is well established that alcohol exposure during prenatal development can lead to a heterogeneous and wide ranging set of morphological and neurobehavioral deficits that are collectively known as Fetal Alcohol Spectrum Disorders (FASDs). Previous neuroimaging research conducted on individuals with FASD has primarily employed graph-theoretical based analysis methods on functional imaging data to elucidate the impact of prenatal alcohol on brain connectivity. This study applied a widely used computational algorithm, group independent components analysis (gICA), to extract coherent sets of voxels that were correlated with one another as a measure of functional network connectivity (FNC) in a sample of …

Relationship Between Structure And Functional Connectivity Within The Default Mode Network, Andrei A. Vakhtin

Psychology ETDs

We proposed a novel measure of conceptualizing dynamic functional network connectivity (FNC) in the human brain using flexibility of functional connectivity (fFC), which captures the variance of functional connectivity across time. In task-free fMRI scans (N = 122), this measure was demonstrated to correspond to the underlying structural connectivity (SC) within the default mode network (DMN), while static functional connectivity (sFC) did so to a relatively low degree. As SC likely does not develop to facilitate task-free brain function, but rather to integrate information during cognitive engagement, we argue that fFC can estimate the potential functional connectivity exhibited outside of …

The Effects Of Moderate Prenatal Alcohol Exposure On Resting State Functional Connectivity And Its Relationship To Behavior, Carlos Rodriguez

Psychology ETDs

It is well established that heavy ethanol exposure during prenatal brain development leads to drastic morphological, cognitive and behavioral consequences. In contrast to heavy exposure, the effects of moderate prenatal alcohol exposure (PAE) are less severe yet continue well into adulthood. Animal models of PAE have been of immense importance to researchers for their ability to control for extraneous variables such as socio economic status, age, nutrition, stress, and co-exposure to other substances. Studies of moderate PAE have investigated several discrete brain regions, neurotransmitter systems, and animal behaviors. However, the effects of moderate PAE on resting state functional network connectivity …