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Evaluation Of The Epidermal Growth Factor Receptor Signaling Pathway As A Therapeutic Target In Human Papillomavirus-Associated Disease, Anastacia Griego
Evaluation Of The Epidermal Growth Factor Receptor Signaling Pathway As A Therapeutic Target In Human Papillomavirus-Associated Disease, Anastacia Griego
Biomedical Sciences ETDs
Human papillomaviruses (HPVs) are the most common sexually transmitted infectious agents. They are responsible for >99% of all cervical cancers as well as subsets of other anogenital cancers. HPVs are also the causative agents of a growing number of head and neck cancers. As such, they present a significant health problem both in the U.S. and developing countries. Much is still unknown regarding the factors underlying progression from HPV infection to cancer or maintenance of viral oncoprotein expression following oncogenic transformation. Previous studies reported significant interplay between the epidermal growth factor (EGFR) pathway and HPV oncoproteins. HPV oncoproteins E5, E6, …
Cancer Experience Modulates The Relationship Between Child And Parent Hypothalamic Pituiatary Adrenal (Hpa) Axis Functioning, Sarah Dinces
Cancer Experience Modulates The Relationship Between Child And Parent Hypothalamic Pituiatary Adrenal (Hpa) Axis Functioning, Sarah Dinces
Psychology ETDs
Objective: We examine how parental stress and pediatric cancer might jointly predict child HPA function using a non-invasive method of cortisol assessment (hair samples). Methods: Parents and children from healthy control and pediatric cancer survivor families participated. Multilevel modeling was applied to data from a nested-design study (85 children, 5-18 years old, from 64 families, healthy controls: n=32; cancer survivors: n=32) to determine the relationship between parent salivary and child hair cortisol measures. Results: No main effect of the cancer experience on child cortisol was found. Parental cortisol positively correlated with child cortisol levels within healthy controls, while there was …