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Oncogene-Dependent Regulation Of Autophagic Flux In Melanoma, Kirsten Anne Meyer White
Oncogene-Dependent Regulation Of Autophagic Flux In Melanoma, Kirsten Anne Meyer White
Biomedical Sciences ETDs
Skin cancer is the one of the most diagnosed cancers in the United States with increasing incidence of 6% every year. In 2015, it is estimated 73,870 new cases of melanoma will be identified and 9,480 individuals will die of their disease. While melanoma only accounts for approximately 2.4% of all cancer related deaths and is the 5th leading diagnosed cancer (US) it is the one of the most common cancers in young adults, age 25-29, particularly for young women. Of particular importance, the mean survival rate of patients diagnosed with metastatic melanoma is six months, with five-year survival rates …
Coordination Between Autophagy And The Heat Shock Response: Evidence From Exercise In Animals And Humans, Nathan H. Cole
Coordination Between Autophagy And The Heat Shock Response: Evidence From Exercise In Animals And Humans, Nathan H. Cole
Health, Exercise, and Sports Sciences ETDs
Proteins play a critical role in nearly every biological activity. In consequence, organismal health and homeostasis often hinges on the ability of intracellular regulatory systems to sustain the quality and function of these diverse, structurally complex macromolecules. Correct protein function depends on correct form, and during periods of destabilizing cellular stress, protein quality is managed in part by the heat shock response, which acts to support, isolate, and reform new or damaged proteins, and in part by the autophagic recycling of abnormal proteins, cytotoxic protein aggregates, and terminally damaged organelles. We conducted a pooled analysis of available research in humans …
Gcn5l1 Functions As A Mitochondrial Acetyltransferase That Regulates Mitophagy, Bradley Roy Webster
Gcn5l1 Functions As A Mitochondrial Acetyltransferase That Regulates Mitophagy, Bradley Roy Webster
Biomedical Sciences ETDs
Caloric restriction (CR) increases lifespan and promotes both longevity and €˜healthy-aging. CR's benefits are dependent in part on NAD-dependent deacetylases known as sirtuins. NAD levels increase with CR promoting sirtuin-mediated deacetylation of lysine residues. Humans express seven sirtuin isoforms that localize to specific sub-cellular compartments. Sirtuins and acetylation affect numerous cellular processes including mitochondrial function. Sirt3 is the major mitochondrial deacetylase and regulates mitochondrial function namely ATP levels, oxidative stress and metabolism. Given the importance of mitochondrial acetylation and Sirt3, we hypothesized the existence of a mitochondrial-localized acetyltransferase that 1) localizes to the mitochondria; 2) has an acetyltransferase domain; and …