Digital Commons Network^™

Spatially Distributed Infection Increases Viral Load In A Computational Model Of Sars-Cov-2 Lung Infection, Melanie E. Moses, Steven Hofmeyr, Judy L. Cannon, Akil Andrews, Rebekah Gridley, Monica Hinga, Kirtus Leyba, Abigail Pribisova, Vanessa Surjadidjaja, Humayra Tasnim, Stephanie Forrest

Pathology Research and Scholarship

A key question in SARS-CoV-2 infection is why viral loads and patient outcomes vary dramatically across individuals. Because spatial-temporal dynamics of viral spread and immune response are challenging to study in vivo, we developed Spatial Immune Model of Coronavirus (SIMCoV), a scalable computational model that simulates hundreds of millions of lung cells, including respiratory epithelial cells and T cells. SIMCoV replicates viral growth dynamics observed in patients and shows how spatially dispersed infections can lead to increased viral loads. The model also shows how the timing and strength of the T cell response can affect viral persistence, oscillations, and control. …

Randomized Controlled Trial Of Early Outpatient Covid-19 Treatment With High-Titer Convalescent Plasma, David J. Sullivan, Kelly A. Gebo, Shmuel Shoham, Bryan Lau, Aarthi G G Shenoy, Giselle S. Mosnaim, Thomas J. Gniadek, Yuriko Fukuta, Bela Patel, Sonya L. Heath, Adam C. Levine, Barry R. Meisenberg, Emily S. Spivak, Shweta Anjan, Moises A. Huaman, Janis E. Blair, Judith S. Currier, James H. Paxton, Jonathan M. Gerber, Joann R. Petrini, Patrick B. Broderick, William Rausch, Marie Elena Cordisco, Jean Hammel, Benjamin Greenblatt, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L. Hammitt, Catherine G. Sutcliffe, Donald N. Forthal, Martin S. Zand, Edward R. Cachay, Jay S. Raval, Seble G. Kassaye, E Colin Foster, Michael Roth, Christi E. Marshall, Anusha Yarava, Karen Lane, Nichol A. Mcbee, Amy L. Gawad, Nicky Karlen, Atika Singh, Daniel E. Ford, Douglas A. Jabs, Lawrence J. Appel, David M. Shade, Stephan Ehrhardt, Sheriza N. Baksh, Oliver Laeyendecker, Andrew Pekosz, Sabra L. Klein, Arturo Casadevall, Aaron A R Tobian, Daniel F. Hanley, Evan M. Bloch, Valerie C. Cluzet

Pathology Research and Scholarship

BACKGROUND: The efficacy of polyclonal high titer convalescent plasma to prevent serious complications of COVID-19 in outpatients with recent onset of illness is uncertain.

METHODS: This multicenter, double-blind randomized controlled trial compared the efficacy and safety of SARS-CoV-2 high titer convalescent plasma to placebo control plasma in symptomatic adults ≥18 years positive for SARS-CoV-2 regardless of risk factors for disease progression or vaccine status. Participants with symptom onset within 8 days were enrolled, then transfused within the subsequent day. The measured primary outcome was COVID-19-related hospitalization within 28 days of plasma transfusion. The enrollment period was June 3, 2020 to …

20211217_Hslic Door Window Decorating Contest, Tamara Wheeler

HSLIC Blog Post

No abstract provided.

20211215_Dr. Eldredge Receives Hsc Faculty Research Excellence Award, Tamara Wheeler

HSLIC Blog Post

No abstract provided.

Comparison Of The Transcriptomic Signatures In Pediatric And Adult Cml, Minyoung Youn, Stephanie M. Smith, Alex Gia Lee, Hee-Don Chae, Elizabeth Spiteri, Jason Erdmann, Ilana Galperin, Lara Murphy Jones, Michele Donato, Parveen Abidi, Henrique Bittencourt, Norman Lacayo, Gary Dahl, Catherine Aftandilian, Kara L. Davis, Jairo A. Matthews, Steven M. Kornblau, Min Huang, Nathan Sumarsono, Michele S. Redell, Cecilia H. Fu, I-Ming Chen, Todd A. Alonzo, Elizabeth Eklund, Jason Gotlib, Purvesh Khatri, E Alejandro Sweet-Cordero, Nobuko Hijiya, Kathleen M. Sakamoto

Pathology Research and Scholarship

Children with chronic myeloid leukemia (CML) tend to present with higher white blood counts and larger spleens than adults with CML, suggesting that the biology of pediatric and adult CML may differ. To investigate whether pediatric and adult CML have unique molecular characteristics, we studied the transcriptomic signature of pediatric and adult CML CD34+ cells and healthy pediatric and adult CD34+ control cells. Using high-throughput RNA sequencing, we found 567 genes (207 up- and 360 downregulated) differentially expressed in pediatric CML CD34+ cells compared to pediatric healthy CD34+ cells. Directly comparing pediatric and adult CML CD34+ cells, 398 genes (258 …

Decreasing Water Supply And Community Health In New Mexico: A Reason For Change, Chelsea Whitney

Climate Change and Public Health Preparedness

No abstract provided.

12/09/2021 Meeting, Kelleen Maluski

Meeting Minutes

No abstract provided.

University Of New Mexico Board Of Regents Minutes For December 7, 2021, University Of New Mexico Board Of Regents

Board of Regents Meeting Minutes

No abstract provided.

20211207_Clinicalkey Resources Available, Robyn Gleasner

HSLIC Blog Post

No abstract provided.

Coalition For Prisoners' Rights Newsletter, Vol. 46-C, No. 12, Coalition For Prisoners' Rights

Coalition for Prisoners' Rights Newsletters

Worse When Poor Too

Pfizer Y Moderna Ganan Millones De $$$

The Least Read Part of the Newsletter

More Law Breakers

International Human Rights Day

Rather Than Pay More

A Few James Baldwin Quotes for All Seasons

Burden Of Mycoplasma Genitalium And Bacterial Coinfections In A Population-Based Sample In New Mexico, Anne Hammer, Patti E. Gravitt, Rachael Adcock, Nicole Patterson, Jack Cuzick, Cosette M. Wheeler

Pathology Research and Scholarship

In this population-based US study, the overall prevalence of Mycoplasma genitalium was 1.95% (95% confidence interval [CI], 1.62%-2.34%), declining from 6.12% (95% CI, 4.72%-7.92%) in women aged 21 to 24 years to 0.48% (95% CI, 0.25%-0.94%) in women aged 40 to 64 years. The prevalence of coinfections with Chlamydia trachomatis and Trichomonas vaginalis was low.

Subcutaneous Testosterone Is Effective And Safe As Gender-Affirming Hormone Therapy In Transmasculine And Gender-Diverse Adolescents And Young Adults: A Single Center's 8-Year Experience, Sarah E. Laurenzano, Ron S. Newfield, Euyhyun Lee, Maja Marinkovic

Pediatrics Research and Scholarship

Purpose: To describe our Center's 8-year experience with subcutaneous testosterone (SC-T) as gender-affirming hormone therapy (GAHT) in transmasculine and gender-diverse (TM/GD) youth. Methods: An Institutional Review Board (IRB)-approved retrospective study for 119 TM/GD subjects who started SC-T at age 13-19 and received SC-T for >6 months between 2012 and 2020. Results: SC-T was typically started at 25-50 mg biweekly and dose was escalated at provider's discretion. Over 96% of subjects were on 100-320 mg monthly (divided weekly or biweekly) at last follow-up. There was an overall increase in mean total and free testosterone (T) over the dose range (p …

Genomes For Kids: The Scope Of Pathogenic Mutations In Pediatric Cancer Revealed By Comprehensive Dna And Rna Sequencing, Scott Newman, Joy Nakitandwe, Chimene A Kesserwan, Elizabeth M Azzato, David A Wheeler, Michael Rusch, Sheila Shurtleff, Dale J Hedges, Kayla V Hamilton, Scott G Foy, Michael N Edmonson, Andrew Thrasher, Armita Bahrami, Brent A Orr, Jeffery M Klco, Jiali Gu, Lynn W Harrison, Lu Wang, Michael R Clay, Annastasia Ouma, Antonina Silkov, Yanling Liu, Zhaojie Zhang, Yu Liu, Samuel W Brady, Xin Zhou, Ti-Cheng Chang, Manjusha Pande, Eric Davis, Jared Becksfort, Aman Patel, Mark R Wilkinson, Delaram Rahbarinia, Manish Kubal, Jamie L Maciaszek, Victor Pastor, Jay Knight, Alexander M Gout, Jian Wang, Zhaohui Gu, Charles G Mullighan, Rose B Mcgee, Emily A Quinn, Regina Nuccio, Roya Mostafavi, Elsie L Gerhardt, Leslie M Taylor, Jessica M Valdez, Stacy J Hines-Dowell, Alberto S Pappo, Giles Robinson, Liza-Marie Johnson, Ching-Hon Pui, David W Ellison, James R Downing, Jinghui Zhang, Kim E Nichols

Pediatrics Research and Scholarship

Genomic studies of pediatric cancer have primarily focused on specific tumor types or high-risk disease. Here, we used a three-platform sequencing approach, including whole-genome sequencing (WGS), whole-exome sequencing (WES), and RNA sequencing (RNA-seq), to examine tumor and germline genomes from 309 prospectively identified children with newly diagnosed (85%) or relapsed/refractory (15%) cancers, unselected for tumor type. Eighty-six percent of patients harbored diagnostic (53%), prognostic (57%), therapeutically relevant (25%), and/or cancer-predisposing (18%) variants. Inclusion of WGS enabled detection of activating gene fusions and enhancer hijacks (36% and 8% of tumors, respectively), small intragenic deletions (15% of tumors), and mutational signatures revealing …

The Report From Asfa Covid-19 Taskforce: Considerations And Prioritization On Apheresis Procedures During The Sars-Cov-2 Coronavirus Disease (Covid-19) Pandemic, Chisa Yamada, Jan C. Hofmann, Volker Witt, Gaurav K. Gupta, Jeffrey L. Winters

Pathology Research and Scholarship

Since vaccination for SARS-CoV-2 coronavirus started, the trajectory of patient numbers infected with the virus has improved once; however, variants of SARS-CoV-2 have emerged and more people have been infected; therefore, pandemic status is still far from resolution. Government and social efforts to prevent coronavirus infection continue in most states in the US and globally even after the Centers for Disease Control and Prevention declared some restriction relief for fully vaccinated people in March 2021. Healthcare institutions and various professional organizations have developed guidelines or policies to prevent the spread of these coronaviruses in the setting of apheresis. In this …

Clinical Follow-Up Practices After Cervical Cancer Screening By Co-Testing: A Population-Based Study Of Adherence To U.S. Guideline Recommendations, Rebecca B. Perkins, Rachael Adcock, Vicki Benard, Jack Cuzick, Alan Waxman, Jean Howe, Stephanie Melkonian, Janis Gonzales, Charles Wiggins, Cosette M. Wheeler

Pathology Research and Scholarship

Failure to follow-up women after abnormal cervical screening could lead to cervical cancers, yet little is known about adherence to recommended follow-up after abnormal co-testing [cytology and high-risk human papillomavirus (hrHPV) testing]. We documented clinical management following cervical screening by co-testing in a diverse population-based setting. A statewide surveillance program for cervical screening, diagnosis, and treatment was used to investigate all cytology, hrHPV and biopsy reports in the state of New Mexico from January 2015 through August 2019. Guideline-adherent follow-up after co-testing required 1) biopsy within 6 months for low-grade cytology if positive for hrHPV, for high-grade cytology irrespective of …

Telehealth During The Covid-19 Pandemic: A Cross-Sectional Survey Of Registered Dietitian Nutritionists, Mary Rozga, Deepa Handu, Kathryn Kelley, Elizabeth Yakes Jimenez, Hannah Martin, Marsha Schofield, Alison Steiber

Pediatrics Research and Scholarship

During the current coronavirus disease 2019 (COVID-19) pandemic, health care practices have shifted to minimize virus transmission, with unprecedented expansion of telehealth. This study describes self-reported changes in registered dietitian nutritionist (RDN) practice related to delivery of nutrition care via telehealth shortly after the onset of the COVID-19 pandemic in the United States. This cross-sectional, anonymous online survey was administered from mid-April to mid-May 2020 to RDNs in the United States providing face-to-face nutrition care prior to the COVID-19 pandemic. This survey included 54 questions about practitioner demographics and experience and current practices providing nutrition care via telehealth, including billing …

Efficacy And Safety Of Low-Dose Versus High-Dose Hydrocortisone To Treat Hypotension In Neonates: A Protocol For A Systematic Review And Meta-Analysis, Katelyn Sushko, Nada Al-Rawahi, Kristi L. Watterberg, John Van Den Anker, Catherine Litalien, Jacques Lacroix, Abdul Razak, Samira Samiee-Zafarghandy

Pediatrics Research and Scholarship

BACKGROUND: Impaired adrenal function is a well-described entity in critically ill term and preterm neonates with systemic hypotension. The standard treatment for neonatal hypotension includes volume expanders and vasopressors. Recent evidence supports the use of glucocorticoids for the primary or rescue treatment of neonatal hypotension associated with impaired adrenal function. However, inconsistency regarding the prescribed dosing regimen to provide the best balance between efficacy and safety in this vulnerable population remains an area of concern.

METHODS: We will conduct a systematic review and meta-analysis to evaluate low-dosing compared with high-dosing regimens of hydrocortisone for the treatment of hypotension in critically …

Editorial: Thrombotic Microangiopathies, Diagnostic And Therapeutic Advances, Robert W. Maitta, Jay S. Raval, Hollie M. Reeves, Magali J. Fontaine

Pathology Research and Scholarship

No abstract provided.

Glomerular Disease In Temporal Association With Sars-Cov-2 Vaccination: A Series Of 29 Cases, Tiffany N. Caza, Clarissa A. Cassol, Nidia Messias, Andrew Hannoudi, Randy S. Haun, Patrick D. Walker, Rebecca M. May, Regan M. Seipp, Elizabeth J. Betchick, Hassan Amin, Mandolin S. Ziadie, Michael Haderlie, Joy Eduwu-Okwuwa, Irina Vancea, Melvin Seek, Essam B. Elashi, Ganesh Shenoy, Sayeed Khalillullah, Jesse A. Flaxenburg, John Brandt, Matthew J. Diamond, Adam Frome, Eugene H. Kim, Gregory Schlessinger, Erlandas Ulozas, Janice L. Weatherspoon, Ethan Thomas Hoerschgen, Steven L. Fabian, Sung Yong Bae, Bilal Iqbal, Kanwalijit K. Chouhan, Zeina Karam, James T. Henry, Christopher P. Larsen

Pediatrics Research and Scholarship

Background: Immune responses to vaccination are a known trigger for a new onset of glomerular disease or disease flare in susceptible individuals. Mass immunization against SARS-CoV-2 in the COVID-19 pandemic provides a unique opportunity to study vaccination-associated autoimmune kidney diseases. In the recent literature, there are several patient reports demonstrating a temporal association of SARS-CoV-2 immunization and kidney diseases.

Methods: Here, we present a series of 29 cases of biopsy-proven glomerular disease in patients recently vaccinated against SARS-CoV-2 and identified patients who developed a new onset of IgA nephropathy, minimal change disease, membranous nephropathy, ANCA-associated GN, collapsing glomerulopathy, or diffuse …

Egfr Transactivates Ron To Drive Oncogenic Crosstalk, Carolina Franco Nitta, Ellen W. Green, Elton D. Jhamba, Justine M. Keth, Iraís Ortiz-Caraveo, Rachel M. Grattan, David J. Schodt, Aubrey C. Gibson, Ashwani Rajput, Keith A. Lidke, Bridget S. Wilson, Mara P. Steinkamp, Diane S. Lidke

Pathology Research and Scholarship

Crosstalk between different receptor tyrosine kinases (RTKs) is thought to drive oncogenic signaling and allow therapeutic escape. EGFR and RON are two such RTKs from different subfamilies, which engage in crosstalk through unknown mechanisms. We combined high-resolution imaging with biochemical and mutational studies to ask how EGFR and RON communicate. EGF stimulation promotes EGFR-dependent phosphorylation of RON, but ligand stimulation of RON does not trigger EGFR phosphorylation - arguing that crosstalk is unidirectional. Nanoscale imaging reveals association of EGFR and RON in common plasma membrane microdomains. Two-color single particle tracking captured formation of complexes between RON and EGF-bound EGFR. Our …

11-30-2021 Hsc Committee Agenda, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Microrna Analysis Of Human Stroke Brain Tissue Resected During Decompressive Craniectomy/Stroke-Ectomy Surgery, Andrew P. Carlson, William Mckay, Jeremy S. Edwards, Radha Swaminathan, Karen S. Santacruz, Ron L. Mims, Howard Yonas, Tamara Roitbak

Pathology Research and Scholarship

BACKGROUND: Signaling pathways mediated by microRNAs (miRNAs) have been identified as one of the mechanisms that regulate stroke progression and recovery. Recent investigations using stroke patient blood and cerebrospinal fluid (CSF) demonstrated disease-specific alterations in miRNA expression. In this study, for the first time, we investigated miRNA expression signatures in freshly removed human stroke brain tissue.

METHODS: Human brain samples were obtained during craniectomy and brain tissue resection in severe stroke patients with life-threatening brain swelling. The tissue samples were subjected to histopathological and immunofluorescence microscopy evaluation, next generation miRNA sequencing (NGS), and bioinformatic analysis.

RESULTS: miRNA NGS analysis detected …

20211122_Zines Care, Colonialism, And Health Happening November 29th-December 3rd, Kelleen Maluski

HSLIC Blog Post

No abstract provided.

A Novel Algorithm Using Cell Population Data (Vcs Parameters) As A Screening Discriminant Between Alpha And Beta Thalassemia Traits, Angeli Ambayya, Santina Sahibon, Thoo Wei Yang, Qian-Yun Zhang, Rosline Hassan, Jameela Sathar

Pathology Research and Scholarship

Thalassemia is one of the major inherited haematological disorders in the Southeast Asia region. This study explored the potential utility of red blood cell (RBC) parameters and reticulocyte cell population data (CPD) parameters in the differential diagnosis of α and β-thalassaemia traits as a rapid and cost-effective tool for screening of thalassemia traits. In this study, a total of 1597 subjects (1394 apparently healthy subjects, 155 subjects with α-thalassaemia trait, and 48 subjects with β-thalassaemia trait) were accrued. The parameters studied were the RBC parameters and reticulocyte CPD parameters derived from Unicel DxH800. A novel algorithm named αβ-algorithm was developed: …

20211122_Hslic's Biomedical Informatics Seminar Series Presents- Melissa Rethlefsen, Msls, Tamara Wheeler

HSLIC Blog Post

No abstract provided.

Bioengineered Models To Study Microenvironmental Regulation Of Glioblastoma Metabolism, Joseph Chen, Hyunchul Lee, Philipp Schmitt, Caleb J. Choy, Donald M. Miller, Brian J. Williams, Elaine L. Bearer, Hermann B. Frieboes

Pathology Research and Scholarship

Despite extensive research and aggressive therapies, glioblastoma (GBM) remains a central nervous system malignancy with poor prognosis. The varied histopathology of GBM suggests a landscape of differing microenvironments and clonal expansions, which may influence metabolism, driving tumor progression. Indeed, GBM metabolic plasticity in response to differing nutrient supply within these microenvironments has emerged as a key driver of aggressiveness. Additionally, emergent biophysical and biochemical interactions in the tumor microenvironment (TME) are offering new perspectives on GBM metabolism. Perivascular and hypoxic niches exert crucial roles in tumor maintenance and progression, facilitating metabolic relationships between stromal and tumor cells. Alterations in extracellular …

20211117_24 7 Study Is Coming Soon To All Floors, Kristin R. Proctor

HSLIC Blog Post

No abstract provided.

20211112_What Are You Thankful For, David Lucero

HSLIC Blog Post

No abstract provided.

Social Informatics Techniques Used To Develop A Tool For Testing Electronic Prescription Systems For Substance Use Management In A Pandemic, Azka Riaz Naru

Biomedical Informatics

Learning Objectives

Effective prescription practices for opioid addicts involve a complex process. This seminar describes how informatics need assessment techniques clarified prescribers’ needs for a software interface.

By completion of this seminar, participants should be able to:

1. Describe how the Covid-19 Pandemic complicated an already complex prescribing decision making process.
2. Summarize how the investigator conducted the needs assessment process using social informatics techniques.

Target Audience

Anyone from UNM or who has an interest in biomedical informatics including physicians, nurses, pharmacists, educators, researchers, faculty, and staff.

Improving Peer Review Of Systematic Reviews By Involving Librarians And Information Specialists: Protocol For A Randomized Controlled Trial, Melissa L. Rethlefsen, Sara Schroter, Lex M. Bouter, David Moher, Ana Patricia Ayala, Jamie J. Kirkham, Maurice P. Zeegers

Publications

BACKGROUND: Problems continue to exist with the reporting quality and risk of bias in search methods and strategies in systematic reviews and related review types. Peer reviewers who are not familiar with what is required to transparently and fully report a search may not be prepared to review the search components of systematic reviews, nor may they know what is likely to introduce bias into a search. Librarians and information specialists, who have expertise in searching, may offer specialized knowledge that would help improve systematic review search reporting and lessen risk of bias, but they are underutilized as methodological peer …