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Tuning Shear Thinning Factors Of 3d Bio-Printable Hydrogels Using Short Fiber, Slesha Tuladhar, Scott Clark, Ahasan Habib
Tuning Shear Thinning Factors Of 3d Bio-Printable Hydrogels Using Short Fiber, Slesha Tuladhar, Scott Clark, Ahasan Habib
New Hampshire EPSCoR
Among various available 3D bioprinting techniques, extrusion-based three-dimensional (3D) bioprinting allows the deposition of cell-laden bioink, ensuring predefined scaffold architecture that may offer living tissue regeneration. With a combination of unique characteristics such as biocompatibility, less cell toxicity, and high water content, natural hydrogels are a great candidate for bioink formulation for the extrusion-based 3D bioprinting process. However, due to its low mechanical integrity, hydrogel faces a common challenge in maintaining structural integrity. To tackle this challenge, the rheological properties, specifically the shear thinning behavior (reduction of viscosity with increasing the applied load/shear rate on hydrogels) of a set of …
3d Bio-Printability Of Hybrid Pre-Crosslinked Hydrogels, Cartwright Nelson, Slesha Tuladhar, Loren Launen, Ahasan Habib
3d Bio-Printability Of Hybrid Pre-Crosslinked Hydrogels, Cartwright Nelson, Slesha Tuladhar, Loren Launen, Ahasan Habib
New Hampshire EPSCoR
Maintaining shape fidelity of 3D bio-printed scaffolds with soft biomaterials is an ongoing challenge. Here, a rheological investigation focusing on identifying useful physical and mechanical properties directly related to the geometric fidelity of 3D bio-printed scaffolds is presented. To ensure during- and post-printing shape fidelity of the scaffolds, various percentages of Carboxymethyl Cellulose (CMC) (viscosity enhancer) and different calcium salts (CaCl2 and CaSO4, physical cross-linkers) were mixed into alginate before extrusion to realize shape fidelity. The overall solid content of Alginate-Carboxymethyl Cellulose (CMC) was limited to 6%. A set of rheological tests, e.g., flow curves, amplitude tests, and three interval …