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Genome Characteristics Of Facultatively Symbiotic Frankia Sp. Strains Reflect Host Range And Host Plant Biogeography, Philippe Normand, Pascal Lapierre, Louis S. Tisa, Johann P. Gogarten, Nicole Alloisio, Emilie Bagnarol, Carla A. Bassi, Alison M. Berry, Derek M. Bickhart, Nathalie Choisne, Arnaud Couloux, Benoit Cournoyer, Stephane Cruveiller, Vincent Daubin, Nadia Demange, Maria Pilar Francino, Eugene Goltsman, Ying Huang, Olga R. Kopp, Laurent Labarre
Genome Characteristics Of Facultatively Symbiotic Frankia Sp. Strains Reflect Host Range And Host Plant Biogeography, Philippe Normand, Pascal Lapierre, Louis S. Tisa, Johann P. Gogarten, Nicole Alloisio, Emilie Bagnarol, Carla A. Bassi, Alison M. Berry, Derek M. Bickhart, Nathalie Choisne, Arnaud Couloux, Benoit Cournoyer, Stephane Cruveiller, Vincent Daubin, Nadia Demange, Maria Pilar Francino, Eugene Goltsman, Ying Huang, Olga R. Kopp, Laurent Labarre
Molecular, Cellular & Biomedical Sciences
Soil bacteria that also form mutualistic symbioses in plants encounter two major levels of selection. One occurs during adaptation to and survival in soil, and the other occurs in concert with host plant speciation and adaptation. Actinobacteria from the genus Frankia are facultative symbionts that form N2-fixing root nodules on diverse and globally distributed angiosperms in the “actinorhizal” symbioses. Three closely related clades of Frankia sp. strains are recognized; members of each clade infect a subset of plants from among eight angiosperm families. We sequenced the genomes from three strains; their sizes varied from 5.43 Mbp for a narrow host …
Zebrafish Acid-Sensing Ion Channel (Asic) 4, Characterization Of Homo- And Heteromeric Channels, And Identification Of Regions Important For Activation By H+, Xuanmao Chen, Georg Polleichtner, Ivan Kadurin, Stefan Grunder
Zebrafish Acid-Sensing Ion Channel (Asic) 4, Characterization Of Homo- And Heteromeric Channels, And Identification Of Regions Important For Activation By H+, Xuanmao Chen, Georg Polleichtner, Ivan Kadurin, Stefan Grunder
Molecular, Cellular & Biomedical Sciences
There are four genes for acid-sensing ion channels (ASICs) in the genome of mammalian species. Whereas ASIC1 to ASIC3 form functional H+-gated Na+ channels, ASIC4 is not gated by H+, and its function is unknown. Zebrafish has two ASIC4 paralogs: zASIC4.1 and zASIC4.2. Whereas zASIC4.1 is gated by extracellular H+, zASIC4.2 is not. This differential response to H+ makes zASIC4 paralogs a good model to study the properties of this ion channel. In this study, we found that surface expression of homomeric zASIC4.2 is higher than that of zASIC4.1. Surface expression of zASIC4.1 was much increased by formation of heteromeric …
Caf1 Plays An Important Role In Mrna Deadenylation Separate From Its Contact To Ccr4, Takbum Ohn, Yueh-Chin Chiang, Darren J. Lee, Gang Yao, Chongxu Zhang, Clyde L. Denis
Caf1 Plays An Important Role In Mrna Deadenylation Separate From Its Contact To Ccr4, Takbum Ohn, Yueh-Chin Chiang, Darren J. Lee, Gang Yao, Chongxu Zhang, Clyde L. Denis
Molecular, Cellular & Biomedical Sciences
The CAF1 protein is a component of the CCR4 - NOT deadenylase complex. While yeast CAF1 displays deadenylase activity, this activity is not required for its deadenylation function in vivo, and CCR4 is the primary deadenylase in the complex. In order to identify CAF1- specific functional regions required for deadenylation in vivo, we targeted for mutagenesis six regions of CAF1 that are specifically conserved among CAF1 orthologs. Defects in residues 213 - 215, found to be a site required for binding CCR4, reduced the rate of deadenylation to a lesser extent and resulted in in vivo phenotypes that were less …