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Implication Of A Retrovirus-Like Glycoprotein Peptide In The Immunopathogenesis Of Ebola And Marburg Viruses, Kavitha Yaddanapudi, Gustavo F. Palacios, Jonathan S. Towner, Ivy Chen, Carlos A. Sariol, Stuart T. Nichol, W. Ian Lipkin
Implication Of A Retrovirus-Like Glycoprotein Peptide In The Immunopathogenesis Of Ebola And Marburg Viruses, Kavitha Yaddanapudi, Gustavo F. Palacios, Jonathan S. Towner, Ivy Chen, Carlos A. Sariol, Stuart T. Nichol, W. Ian Lipkin
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Ebola and Marburg viruses can cause hemorrhagic fever (HF) outbreaks with high mortality in primates. Whereas Marburg (MARV), Ebola Zaire (ZEBOV), and Ebola Sudan (SEBOV) viruses are pathogenic in humans, apes, and monkeys, Ebola Reston (REBOV) is pathogenic only in monkeys (1–3). Early immunosuppression may contribute to pathogenesis by facilitating viral replication (4–6). Lymphocyte depletion, intravascular apoptosis, and cytokine dysregulation are prominent in fatal cases (7). Here we functionally characterize a 17 amino acid domain in filoviral glycoproteins that resembles an immunosuppressive motif in retroviral envelope proteins (8, 9). Activated human or rhesus peripheral blood mononuclear cells (PBMC) were exposed …