Digital Commons Network^™

Biological Teleology In The Modern World, Kathryn Siena

Honors Theses

In humans, the heart moves blood through the body. Does the heart therefore have a teleological explanation? Aristotelian teleology (described in Aristotle’s Physics) is the cause-for-the-sake-of-which, or the end towards which something moves. It is evident from current scientific knowledge that there is some sort of orientation of organisms toward an end. This orientation, following Aristotle’s definition of teleology, is conceptually distinct from efficient causation. This orientation is also metaphysically distinct from efficient causation because efficient causal explanations do not properly describe the orientation. However, two common ways of describing teleological explanations imply efficient causation as a metaphysical element. …

Extranodal Tumors And Chromosomal Abnormalities Associated With Non-Hodgkin Lymphoma In T(14;18)-Positive Patients, Alexis Finch

Honors Theses

Nebraska is mostly an agricultural state with a non-Hodgkin lymphoma (NHL) incidence rate of 20.1 per 100,000 individuals, which is greater than the US incidence rate of 19 per 100,000 individuals. It is possible that the higher incidence rate in Nebraska is due to an increase in pesticide usage. Pesticide exposure is linked to t(14;18), a genetic translocation involving the BCL2 gene that regulates apoptosis. The dysregulation of apoptosis could contribute to the proliferation of NHL. This exploratory study utilized the Nebraska Lymphoma Study Group, which consists of patients with non-Hodgkin lymphoma, Hodgkin disease, or some other neoplastic hematologic disorder …

The Concentration Of Heavy Metals In Lincoln Nebraska's Tap Water, Evan Neuhaus

Honors Theses

Heavy metals are commonplace in nature, and are typically found in scarce quantities in all drinking sources. However, in high enough concentrations, they can have a myriad of negative health effects. This study seeks to find the concentrations of such metals in the Lincoln water supply utilizing the resources of the Water Center at the University of Nebraska at Lincoln. To test for discrete concentrations of trace elements, a method of using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) was implemented. ICP-MS uses plasma to ionize and atomize a sample which is then filtered into a series of cones into a …

Utilizing Markov Chains To Estimate Allele Progression Through Generations, Ronit Gandhi

Honors Theses

All populations display patterns in allele frequencies over time. Some alleles cease to exist, while some grow to become the norm. These frequencies can shift or stay constant based on the conditions the population lives in. If in Hardy-Weinberg equilibrium, the allele frequencies stay constant. Most populations, however, have bias from environmental factors, sexual preferences, other organisms, etc. We propose a stochastic Markov chain model to study allele progression across generations. In such a model, the allele frequencies in the next generation depend only on the frequencies in the current one.

We use this model to track a recessive allele …

Bacteriophage That Infect Gordonia Species Show Varying Host Specificity And Infection, Lindsay Birge

Honors Theses

Bacteriophage (phage) are an incredibly abundant species of virus that infect bacteria. One major characteristic of phage is their small host range- many phage are known to infect only one or a few hosts. This phage and host relationship has led to phage therapy recently becoming highlighted as a possible alternative to traditional antibiotics in light of the growing antibiotic resistance crisis. The study of phage host specificity has risen in line with this concept, as a phage with a more extensive host range can provide more opportunities for use as an antibiotic. Samples of phage previously isolated on a …

Can Gdp Be Predictive Of Fertility Rates In Sweden?, Hannah Coleman

Honors Theses

Fertility rates in a country vary and can be influenced by numerous different aspects of an individual’s life and the society in which they live. One aspect that may influence fertility rates at the national level is the gross domestic product (GDP). GDP is an indicator of a country’s economic productivity. Because fertility is linked to both economic development and individual resources, GDP may be a useful indicator of fertility rates. If so, knowing or predicting GDP could be used to project the fertility rates of a population years into the future. To determine if a reasonable connection between GDP …

Teaching Muscle Function And Physical Fitness: An Afterschool Program For Elementary Schools, Julianna Peters

Honors Theses

For this creative project, a nine-week club curriculum about muscle function and exercise was designed for upper elementary students (4^th-6^th grade), integrating science and physical education. This curriculum aims to introduce students to a basic understanding of muscle function and their body utilizing a scientific lens while also encouraging movement through the education of different muscle groups. It principally covers the three types of muscle with an emphasis on skeletal muscles. Students engage in experiments and activities focused on different aspects of muscle function and then do exercises focused on certain muscle groups. Additionally, it aims to …

Inheritability Of Ciprofloxacin-Induced Mitochondrial Mutations From Parental To Offspring Generation Using Quantitative Polymerase Chain Reaction, Rose Mccoy

Honors Theses

In all eukaryotes, mitochondria are known as the powerhouse of the cell (Siekevitz, 1957). In plants, however, their mitochondrial genome is especially strange. Plant mitochondrial genomes are extremely large and contain both linear and circular subgenomic DNA fragments. Plant mitochondrial genomes undergo a significant amount of mutations in the form of rearrangements. However, it is not known how often these rearrangements are inherited by the next generation. It is thought that plant cells that are still dividing have higher rates of DNA repair, such as double-strand break repair, to ensure the quality of that plant lineage. As follows, it is …

Membrane Lipid Extraction Methods From Sorghum Bicolor, Max Regester

Honors Theses

Plants are the basis of the world as we know it. As sessile beings, there are often subject to many environment stressors like drought, extreme temperatures, etc. One way of analyzing how plants respond to these stressors is by monitoring changes in their lipid compositions. Having a better understanding of how plants respond to different stressors can have very important implications when it comes to cultivating crops. When testing lipid composition, it is important to measure levels as they were in the living tissue. The problem is, enzymes known as lipases are active during extraction and can greatly change the …

Adaptations Of Interferon Regulatory Factor 3 During Transition From Terrestrial To Aquatic Life, Monica Angeletti

Honors Theses

Interferon regulatory factor 3 (IRF3) and IRF7 are closely related IRF members and play a major role in the induction of interferons, which are a key component in vertebrate innate immunity. However, there is limited knowledge regarding the evolution and adaptation of these IRFs to the environment. Two unique motifs in IRF3 and 7 were identified. One motif, GASSL, is highly conserved throughout the evolution of IRF3 and 7 and located in the signal response domain. Another motif, DPHK, is in the DNA-binding domain. The ancestral protein of IRF3 and 7 seemed to possess the DPHK motif. In the ray-finned …

H/L Ratio As A Measurement Of Immune Function In Terrapene Ornata Species, Vesa Govori

Honors Theses

White blood cells are a key part of the immune system, and changes in white cell count can reveal the overall state of health and the immune systems functional ability of a species. White blood such as heterophils and lymphocytes are essential for being able to fight off infections. Analyzing different cell ratios has been commonly done before as a way to observe immune function in bird species as well as other species. Understanding that there are different functions between the different white blood cells provides an extra interesting perspective to what could be happening in the immune system function …

Student Perceptions Of Reasons For Lecture And Active Learning, Calan Koch

Honors Theses

With perceived student resistance to active learning in the classroom, instructors are hesitant to implement such methods into their classroom structure despite how effective they may be. This research seeks to understand student perceptions related to the transition to higher prevalence of active learning techniques. We aimed to find answers to how students perceive the ideal classroom to be structured, what reasons they perceive for lecture and active learning components, and possible explanations to concerns of groupwork during class time. We analyzed 64 interviews with undergraduate biology students at the University of Nebraska- Lincoln, developed coding rubrics from commonly found …

Investigating The Role Of Free Radicals In Huntington's Disease Using Drosophila Melanogaster, Jennifer Libov

Honors Theses

During normal cell metabolism, reactive oxygen species (ROS) are produced as a byproduct of oxidative phosphorylation. ROS are utilized in the cell as a signaling molecule and can be maintained at healthy levels by cellular antioxidants. However, when the cell experiences oxidative stress due to environmental or genetic conditions, levels of ROS can exceed healthy levels and inhibit necessary life functions by damaging biomolecules and cellular structures. This loss of function can lead to physiological decline and neurodegeneration, such as in diseases like Alzheimer’s, amyotrophic lateral sclerosis (ALS), and, potentially, Huntington’s disease. The following experiments use the model genetic organism …

Enduring Chronic Kidney Disease: An Investigation Of Psychosocial Factors And Life Satisfaction In Older Adults Receiving Dialysis Treatment, Bailee Sobotka

Honors Theses

Chronic kidney disease is a condition during which the kidneys begin to shut down and no longer filter blood efficiently. Once the disease has progressed far enough, dialysis treatments are mandatory to sustain life. To further understand how older adults receiving dialysis treatments cope with their disease, psychosocial factors were evaluated to investigate possible correlations with life satisfaction using a Life Satisfaction Index Z (LSI-Z). Expected correlations with life satisfaction were sociability, financial satisfaction, importance of spirituality, and activities of daily living scores. Interviews were conducted with 30 dialysis patients and results were analyzed using various statistical measures. Significant correlations …