A Tree-Based Multiscale Regression Method, Haiyan Cai, Qingtang Jiang

Mathematics and Statistics Faculty Works

A tree-based method for regression is proposed. In a high dimensional feature space, the method has the ability to adapt to the lower intrinsic dimension of data if the data possess such a property so that reliable statistical estimates can be performed without being hindered by the “curse of dimensionality.” The method is also capable of producing a smoother estimate for a regression function than those from standard tree methods in the region where the function is smooth and also being more sensitive to discontinuities of the function than smoothing splines or other kernel methods. The estimation process in this …

Lipg A Bifunctional Phospholipase/Thioesterase Involved In Mycobacterial Envelope Remodeling, Christopher Spilling, Pierre Santucci, Vanessa Point, Isabelle Poncin, Alexandre Guy, Celine Crauste, Carole Serveau-Avesque, Jean Galano, Jean-Francois Cavalier, Stephane Canaan

Chemistry & Biochemistry Faculty Works

Tuberculosis caused by Mycobacterium tuberculosis is currently one of the leading causes of death from an infectious agent. The main difficulties encountered in eradicating this bacteria are mainly related to (i) a very complex lipid composition of the bacillus cell wall, (ii) its ability to hide from the immune system inside the granulomas, and (iii) the increasing number of resistant strains. In this context, we were interested in the Rv0646c (lipGMTB) gene located upstream to the mmaA cluster which is described as being crucial for the production of cell wall components and required for the bacilli adaptation and survival in …

Systematics Of Malesian-Pacific Piper (Piperaceae), Rani Asmarayani

Dissertations

Comprised of ~2400 spp., Piper is a major clade in the magnoliid angiosperms. Three major groups are recognized in Piper, i.e., the Neotropical, Asian and South Pacific. Unlike Neotropical Piper,relationships in the Paleotropical Piper remain enigmatic. This study focused on the Paleotropical Piperwith emphasize on the Malesian-Pacific Piper, Malesia being the center of diversity of the genus in the Paleotropics. The goals are to evaluate relationships within Paleotropical Piper (chapter 1), to evaluate characters, morphological (chapter 1) and stem anatomical (chapter 2), that may distinguish clades, and to investigate the species boundaries focusing on the well-supported …

The Dynamical State Of A Young Stellar Cluster, Timothy Sullivan

Dissertations

The dynamical state of the young star-forming cluster Rho Ophiuchi is considered, with emphasis on the L1688 cloud. Radial velocities are derived for 32 YSOs, with some being multi-epoch, using Markov-Chain Monte Carlo routines based upon the package emcee. Sources are chosen based upon their spectral index to focus on the earlier stages of star formation, in this case, Class I and Flat spectrum objects, and compared with a sample of Class II and III objects from the same embedded cluster. It is found that the radial velocity dispersion for these younger objects is ∆v = 2.8 ± 0.6 km …

Try To Remember Breath, Rita Chapman

Theses

A collection of original poems.

Asymptotic Properties For Methods Combining The Minimum Hellinger Distance Estimate And The Bayesian Nonparametric Density Estimate, Yuefeng Wu, Giles Hooker

Mathematics and Statistics Faculty Works

In frequentist inference, minimizing the Hellinger distance between a kernel density estimate and a parametric family produces estimators that are both robust to outliers and statistically efficient when the parametric family contains the data-generating distribution. This paper seeks to extend these results to the use of nonparametric Bayesian density estimators within disparity methods. We propose two estimators: one replaces the kernel density estimator with the expected posterior density using a random histogram prior; the other transforms the posterior over densities into a posterior over parameters through minimizing the Hellinger distance for each density. We show that it is possible to …

An Analysis And Evaluation Of The Wefold Collaborative For Protein Structure Prediction And Its Pipelines In Casp11 And Casp12, Chen Keasar, Liam J. Mcguffin, Björn Wallner, Gaurav Chopra, Badri Adhikari, Debswapna Bhattacharya, Lauren Blake, Leandro Oliveira Bortot, Renzhi Cao, B. K. Dhanasekaran, Itzhel Dimas, Rodrigo Antonio Faccioli, Eshel Faraggi, Robert Ganzynkowicz, Sambit Ghosh, Soma Ghosh, Artur Giełdoń, Lukasz Golon, Yi He, Lim Heo, Jie Hou, Main Khan, Firas Khatib, George A. Khoury, Chris Kieslich, David E. Kim, Pawel Krupa, Gyu Rie Lee, Hongbo Li, Jilong Li, Agnieszka Lipska, Adam Liwo, Ali Hassan A. Maghrabi

Computer Science Faculty Works

Every two years groups worldwide participate in the Critical Assessment of Protein Structure Prediction (CASP) experiment to blindly test the strengths and weaknesses of their computational methods. CASP has significantly advanced the field but many hurdles still remain, which may require new ideas and collaborations. In 2012 a web-based effort called WeFold, was initiated to promote collaboration within the CASP community and attract researchers from other fields to contribute new ideas to CASP. Members of the WeFold coopetition (cooperation and competition) participated in CASP as individual teams, but also shared components of their methods to create hybrid pipelines and actively …

An Analysis And Evaluation Of The Wefold Collaborative For Protein Structure Prediction And Its Pipelines In Casp11 And Casp12., Chen Keasar, Liam Mcguffin, Björn Wallner, Gaurav Chopra, Badri Adhikari, Debswapna Bhattacharya, Lauren Blake, Leandro Bortot, Renzhi Cao, B. Dhanasekaran, Itzhel Dimas, Rodrigo Faccioli, Eshel Faraggi, Robert Ganzynkowicz, Sambit Ghosh, Soma Ghosh, Artur Giełdoń, Lukasz Golon, Yi He, Lim Heo, Jie Hou, Main Khan, Firas Khatib, George Khoury, Chris Kieslich, David Kim, Pawel Krupa, Gyu Lee, Hongbo Li, Jilong Li, Agnieszka Lipska, Adam Liwo, Ali Maghrabi, Milot Mirdita, Shokoufeh Mirzaei, Magdalena Mozolewska, Melis Onel, Sergey Ovchinnikov, Anand Shah, Utkarsh Shah, Tomer Sidi, Adam Sieradzan, Magdalena Ślusarz, Rafal Ślusarz, James Smadbeck, Phanourios Tamamis, Nicholas Trieber, Tomasz Wirecki, Yanping Yin

Computer Science Faculty Works

Every two years groups worldwide participate in the Critical Assessment of Protein Structure Prediction (CASP) experiment to blindly test the strengths and weaknesses of their computational methods. CASP has signifcantly advanced the feld but many hurdles still remain, which may require new ideas and collaborations. In 2012 a web-based efort called WeFold, was initiated to promote collaboration within the CASP community and attract researchers from other felds to contribute new ideas to CASP. Members of the WeFold coopetition (cooperation and competition) participated in CASP as individual teams, but also shared components of their methods to create hybrid pipelines and actively …

A Scoping Review Of The Associations Between Mental Health And Factors Related To Hiv Acquisition And Disease Progression In Conflict-Affected Populations, Erica Koegler, Erica Koegler, Caitlin Kennedy

Social Work Faculty Works

The association between poor mental health and factors related to HIV acquisition and disease progression (also referred to as HIV-related factors) may be stronger among conflict-affected populations given elevated rates of mental health disorders. We conducted a scoping review of the literature to identify evidence-based associations between mental health (depression, anxiety, and post-traumatic stress disorder [PTSD]) and factors related to HIV acquisition and progression in conflict-affected populations. Five electronic databases were searched on October 10, 2014 and updated on March 7, 2017 to identify peer-reviewed publications presenting primary data from January 1, 1994 to March 7, 2017. Articles were included …

The Evolution Of Psychological Altruism, Gualtiero Piccinini, Armin Schulz

Philosophy Faculty Works

We argue that there are two different kinds of altruistic motivation: classical psychological altruism, which generates ultimate desires to help other organisms at least partly for those organisms’ sake, and nonclassical psychological altruism, which generates ultimate desires to help other organisms for the sake of the organism providing the help. We then argue that classical psychological altruism is adaptive if the desire to help others is intergenerationally reliable and, thus, need not be learned. Nonclassical psychological altruism is adaptive when the desire to help others is adaptively learnable. This theory opens new avenues for the interdisciplinary study of psychological altruism.

Generating High-Order Optical And Spin Harmonics From Ferromagnetic Monolayers, G.P. Zhang, M.S. Si, M. Murakami, Y.H. Bai, Thomas George

Chemistry & Biochemistry Faculty Works

High-order harmonic generation (HHG) in solids has entered a new phase of intensive research, with envisioned band-structure mapping on an ultrashort time scale. This partly benefits from a flurry of new HHG materials discovered, but so far has missed an important group. HHG in magnetic materials should have profound impact on future magnetic storage technology advances. Here we introduce and demonstrate HHG in ferromagnetic monolayers. We find that HHG carries spin information and sensitively depends on the relativistic spin–orbit coupling; and if they are dispersed into the crystal momentum k space, harmonics originating from real transitions can be k-resolved and …

Missouri-Iowa Science Cooperative (Science Co-Op), James Shymansky, Larry Yore, Leonard Annetta, Susan Everett

Educator Preparation & Leadership Faculty Works

No abstract provided.

Looking Past The Images: Art And Film As Propaganda Apparatuses, Alexander Schumm

Theses

This paper aims to show that art and film can operate as propaganda in subtle and unintentional ways. Jacques Ellul called such propaganda “sociological propaganda.” Recent work in philosophy has relied on the notion of intention in defining how propaganda works to affect the beliefs and attitudes of its recipients. This paper argues that intention is not a necessary condition for messages to be propagandistic and works to decouple propaganda from intention. Because our current models rely on intention in defining propaganda, recent work in philosophy cannot account for sociological propaganda. Ellul’s gestures toward defining propaganda explicitly feature intention as …

A Multi-Skilled Approach To Property Maintenance Considering Temporal, Spatial And Resource Constraints, Anthony G. Vatterott

Dissertations

With the continued increase in age of the United States housing and building stock, as well as the continued need to maintain properties across the U.S., the need for timely, cost-optimal maintenance is ever more critical. This paper proposes the application of a mathematical model to aid in the scheduling and assignment of construction and maintenance tasks, considering the multi-skilled workforce. The benefit of this approach is to take advantage of the economies of scale that can be developed using cross-functional skilled workers with varying levels of competence and efficiency. This approach schedules and assigns tasks using data from maintenance …

Gone To Ground, Brian Blair

Theses

Gone to Ground is a collection of short stories that explores the possibilities beyond the edge of the everyday. They are an attempt to peek beyond the imaginary boundaries we erect for ourselves in the name of danger or the unknown. Each story is an opportunity to see our own familiar humanity in others, no matter the accidents of fortune that separate us. Though the stories in Gone to Ground often touch the surreal or the magical, they are firmly rooted in what could be out there, on the other side of our walls, whether real or imagined. These are …

Temporal Changes In The Diversity And Composition Of Tropical Andean Forest Communities, Claudia Andrea Aparicio-Chavez

Theses

During the last few thousand years, human population growth and resource use has been reshaping the planet’s nutrient cycles, climate and biodiversity and might be causing significant changes to spatial and temporal patterns in the distribution of species, and a general erosion of biodiversity at global scales. Many studies have been looking to model and predict how species could respond to actual rates of change on environmental conditions, with a high interest in terms of species distribution and richness with potential extinctions. However, how global change impact local communities still remains unclear. Moreover, previous research suffers from a significant bias …

The Meaning Of A Family History Of Colorectal Cancer In Black Families In The United States, Cassandra Loggins

Dissertations

The purpose of this study is to understand the meaning of a family history of colorectal cancer (CRC) for first-degree relatives of Blacks diagnosed with CRC. Even though CRC is more preventable than other cancers because of effective screening tests for prevention and early detection, Blacks experience a disproportionate burden of CRC compared to other groups. Interventions to increase CRC screening among Blacks have not produced a significant reduction in CRC disparity. Underutilization of CRC screening and low perceived risk of CRC are major factors contributing to CRC disparity. The informing methodological approach employed in this study was hermeneutic phenomenology, …

Evolution Of Bidirectional Costly Mutualism From Byproduct Consumption, Lon Chubiz, William Harcombe, Jeremy Chacón, Elizabeth Adamowicz, Christopher Marx

Biology Department Faculty Works

Mutualisms are essential for life, yet it is unclear how they arise. A two-stage process has been proposed for the evolution of mutualisms that involve exchanges of two costly resources. First, costly provisioning by one species may be selected for if that species gains a benefit from costless byproducts generated by a second species, and cooperators get disproportionate access to byproducts. Selection could then drive the second species to provide costly resources in return. Previously, a synthetic consortium evolved the first stage of this scenario: Salmonella enterica evolved costly production of methionine in exchange for costless carbon byproducts generated by …

Puf Proteins: Regulation Of Condition-Specific Mrna Decay And Contributions To Ribosome Biogenesis In Yeast, Anthony Fischer

Dissertations

Regulation of protein expression is critical to organism survival. Multiple disease states arise from aberrant accumulation/aggregation of proteins or reduced production of key enzymes. Cells have many ways to manipulate protein levels, including transcription factors, chromatin modification, modification of messenger RNA (mRNA), and manipulation of proteolytic protein decay. Cells can indirectly control protein volume by controlling mRNA lifespan, which is directly correlated with protein output. Often, sequence-specific elements in mRNA contribute to this lifespan. The Puf family of RNA-binding proteins is ubiquitous throughout eukarya, and plays important cellular and developmental roles through mRNA lifespan regulation. Puf proteins contain a C-terminal …

A Parallelized Implementation Of Cut-And-Solve And A Streamlined Mixed-Integer Linear Programming Model For Finding Genetic Patterns Optimally Associated With Complex Diseases, Michael Yip-Hin Chan

Theses

With the advent of genetic sequencing, there was much hope of finding the inherited elements underlying complex diseases, such as late-onset Alzheimer’s disease (AD), but it has been a challenge to fully uncover the necessary information hidden in the data. A likely contributor to this failure is the fact that the pathogenesis of most complex diseases does not involve single markers working alone, but patterns of genetic markers interacting additively or epistatically. But as we move upwards beyond patterns of size two, it quickly becomes computationally infeasible to examine all combinations in the solution space. A common solution to solving …

Eye Examination:Satisfying A Quality Care Measure In Diabetes, Meera Shekar

Dissertations

Abstract

Purpose: Diabetic retinopathy (DR), a microvascular complication occurs in patients with poorly controlled diabetes mellitus (DM). A known risk of increased visual impairment associated with DM occurs in patients when the glycosylated hemoglobin level (HbA1c) increases over 7.0%. Therefore, an annual retinal assessment as a quality care measure in diabetes management is necessary. The conducted study aimed to evaluate the documentation of an annual eye exam in all patients with DM in a private family practice clinic and to investigate any possible association between HbA1c level.

Method: This quality improvement study included a retrospective medical record review in …

Application Of Glycosyl Imidates And Nitrates In Carbohydrate Synthesis, Tinghua Wang

Dissertations

Carbohydrates are the most abundant molecules among the four essential classes of biomolecules that also include nucleic acids, lipids and proteins. Unlike proteins and nucleic acids, which follow template-driven synthetic pathways, there is no general route to the synthesis of carbohydrates. The stereoselectivity of the formation of O-glycosidic linkages and the regioselectivity of protection and deprotection of specific hydroxyl groups over others represent two of the major challenges in carbohydrate chemistry. This thesis is dedicated to the development of novel strategies for efficient synthesis of carbohydrate building blocks and stereocontrolled glycosylations for step-economy oligosaccharide synthesis. Novel glycosyl donors with difluoro-3H-indol-2-yl …

Motivation Predicts Self-Control Of Racial Bias After Viewing Alcohol Advertisements, Zachary Wolfgang Petzel

Dissertations

Exerting self-control shifts motivation toward rewarding cues (i.e., approach motivation) and impairs control of racial bias. However, whether approach motivation predicts deficits in control of racial bias is unknown. Exertion of self-control is also related to alcohol use, but whether exerting self-control shifts motivation toward alcohol-related cues is not established. Similar to exerting self-control, viewing alcohol-related cues shifts motivation and promotes racial bias. The current study examined the interaction between exerting self-control and viewing alcohol-related cues on approach motivation and its influence on racial bias. Participants (N = 71) exerted (or did not exert) self-control and then viewed neutral …

Teacher Perceptions Of Ability In Implementing A Culturally Responsive Educational Practice For Culturally Linguistically Diverse Students With Dis/Abilities, Melanie Ziebatree

Dissertations

All children in the United States have the right to an equitable education, regardless of gender, religion, class, race, culture, language, or dis/ability. The literature demonstrates that financial, educational, and legal outcomes are disproportionately negative for those students falling outside of white able-bodied norms and that educational institutions often perpetuate exclusive policies and practices that disproportionately impact culturally linguistically diverse students with dis/abilities. A critical examination of the sociopolitical and contextual factors that fortify the barriers faced by marginalized groups highlights the need for a culturally responsive approach to educating students with multidimensional identities.

To serve the needs resulting from …

Resilience And College Persistence: Characterizing Students Who Have Failed Courses, Mary Merrifield

Dissertations

Students who fail a course early in their college careers are at risk of leaving college before completion of their programs. Little is known about this high-risk group and why some members of this group complete their programs while others do not. This research addressed this gap in the college-level persistence literature by focusing first on differences between completers and non-completers, then on differences between students who fail a course early in their college careers but become completers or non-completers. The goal was to understand the protective value of individual traits beyond the prediction of risk based on membership to …

An Introduction To Psychological Statistics, Garett C. Foster, David Lane, David Scott, Mikki Hebl, Rudy Guerra, Dan Osherson, Heidi Zimmer

Open Educational Resources Collection

This work has been superseded by Introduction to Statistics in the Psychological Sciences available from https://irl.umsl.edu/oer/25/.

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We are constantly bombarded by information, and finding a way to filter that information in an objective way is crucial to surviving this onslaught with your sanity intact. This is what statistics, and logic we use in it, enables us to do. Through the lens of statistics, we learn to find the signal hidden in the noise when it is there and to know when an apparent trend or pattern is really just randomness. The study of statistics involves math and relies …

Nanoporous Carbon Scaffolds For Energy Storage Applications, Waruni Jayawardana

Dissertations

Nanoporous carbons (NCs) have become increasingly popular in various fields of research due to their unique properties including tunable pore sizes, higher pore volumes and higher surface areas, as well as being able to produce controlled nanostructures. The work presented here uses NC scaffolds with as active hosts for (1) Li-ion battery electrodes and (2) confined metal hydrides (MH) for hydrogen storage applications. In (1) we investigate the Li diffusion characteristics in hard carbons (HCs) that are important for electrochemical applications. We develop a novel method named Voltage-Relaxation Galvanostatic Intermittent Titration Technique (VR-GITT). Parameters derived from the fitting of electrochemical …

How School Counselors Cope With Student Suicide: A Qualitative Study, Sara Carpenter

Dissertations

Recognizing that school counselors will likely encounter the tragedy of youth suicide, many counselor educator programs focus on identification of suicidal ideation and prevention, but the field of school counseling remains largely under-equipped regarding how to cope with the aftermath of student suicide. In an effort to expand the qualitative research within the profession on how best to educate, support, and implement suicide postvention strategies, there remained a need to explore the experience of the school counselor in the aftermath of such tragedy. This study addressed how school counselors who were trained in CACREP-accredited programs experience the response to student …

Unmasking Whiteness: Progressing Toward Cultural Responsiveness Within A Rti Framework, Melinda F. Scheetz

Dissertations

Response to Intervention (RTI) developed out of educational policies and practices that comprise NCLB and IDEA. RTI is a system to ensure all students receive high-quality instruction that meets their needs, increases opportunities to learn, and prevents reading failure. A culturally relevant RTI framework offers the most promising pedagogical approach to quality instruction and educational equity. The purpose of this study was to understand, describe, and explore the intersection of culturally relevant practices and RTI. The research questions that guided this study were: What can be learned about a culturally responsive approach to RTI by listening to teachers’ perspectives and …

An Analysis Of African-American Faculty Experiences During The Tenure Process, Katrina M. Hubbard

Dissertations

Abstract

How faculty allocate their time among research, teaching, and service, and the perceived quality of that work determines whether faculty obtain tenure or are released from the university (Bellas & Toutkoushian, 1999; Link, Swann, & Bozeman, 2008; Price & Cotten, 2006). Prior research indicated that African-American faculty comprised 4.5% of the faculty at high-activity research institutions and 3.5% of faculty at very-high-activity research institutions (The Chronicle of Higher Education Almanac 2016-2017, 2016).

The purpose of this study was to 1) document African-American faculty experiences during their tenure probationary period at PWI research institutions; 2) compare faculty experiences during the …