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Role Of Breastfeeding Duration, Maternal Smoking During Pregnancy, And Dna-Methylation For The Risk Of Eczema, Nandini Mukherjee
Role Of Breastfeeding Duration, Maternal Smoking During Pregnancy, And Dna-Methylation For The Risk Of Eczema, Nandini Mukherjee
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Prior studies linking breastfeeding duration and maternal gestational smoking, respectively, to offspring eczema report contradictory findings. However, it is not known whether maternal gestational smoking and breastfeeding duration can jointly influence eczema and whether these exposures mediate their effect on eczema via DNA Methylation (DNA-M) of CpG (cytosine-phosphate-guanine) sites. With data from the Isle of Wight (IOW) birth cohort, UK, we first evaluated the combined effect of maternal gestational smoking and breastfeeding duration on eczema at ages 1-to-2 (n=980), 4 (n=902), 10 (n=966), and 18 years (n=929) using Generalized estimating equations (GEE). We found a protective effect of longer duration …
The Transgenerational Effect Of Maternal Grandmothers Body Mass Index And Socioeconomic Status On Offspring Birth Weight: The Mediation Effect Of Maternal Birth Weight, Early Adulthood Bmi, And Dna Methylation, Yan Shen
Electronic Theses and Dissertations
Prior research demonstrated intergenerational effects of maternal risk factors on offspring birth weight. However, only a limited number of studies investigated whether grand-maternal risk factors, i.e. body mass index (BMI) and socioeconomic status (SES), affected grandchilds birth weight (GBW). Besides, it is unknown whether such associations are direct or mediated by maternal risk factors. Grand-maternal smoking during pregnancy was additionally included due to many studies addressing the adverse effect of maternal smoking on birth weight. I used three-generation data from Isle of Wight birth cohort in UK and performed structural equation models (SEM) to assess the associations between grand-maternal risk …