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Systemic Oxytocin Administration Alters Mesolimbic Dopamine Relase, Mary Kathlyn Estes
Systemic Oxytocin Administration Alters Mesolimbic Dopamine Relase, Mary Kathlyn Estes
Electronic Theses and Dissertations
Growing research indicates oxytocin may be involved in relieving anxiety and attenuating the rewarding effects of psychostimulants. The present study investigated the effects of subchronic oxytocin treatments on mesolimbic dopamine transmission in areas associated with anxiety (amygdala) and addiction (nucleus accumbens, NAc). Using in vivo fixed potential amperometry, stimulation-evoked dopamine release was recorded either in the amygdala or NAc in oxytocin pretreated mice. During dopamine recordings, mice received a drug challenge of either oxytocin, the dopamine reuptake blocker nomifensine (psychostimulant), or saline. In the amygdala, dopamine release was decreased following the oxytocin challenge but only in oxytocin pretreated mice. In …
An Architecture Beyond The Walls: Aligning Mind, Body, And Soul For Human Connection, Priya Kharel
An Architecture Beyond The Walls: Aligning Mind, Body, And Soul For Human Connection, Priya Kharel
Electronic Theses and Dissertations
The pace of urbanization is deepening a sense of social isolation. The brutality of urban settings allows limited access to nature resulting in stress, anxiety, and depression among city dwellers. To bridge the gap of human disconnection, this thesis project proposes an architecture of connection: A connection of mind, body, and soul, with nature as the medium. This connection is achieved by actively designing for the senses, in order to reconnect city dwellers with the built environment. Architecture with nature at its heart can produce a beautiful way of living. To understand this lived experience, phenomenological architecture is discussed, and …
Arachidonoyl Serotonin (Aa-5-Ht) Modulates Exploratory Anxiety-Related Behavior And Tunes Mesolimbic Dopamine Transmission, Timothy Glenn Freels
Arachidonoyl Serotonin (Aa-5-Ht) Modulates Exploratory Anxiety-Related Behavior And Tunes Mesolimbic Dopamine Transmission, Timothy Glenn Freels
Electronic Theses and Dissertations
Cannabinergic and vanilloidergic signaling are mechanisms of interest for the treatment of anxiety symptoms due to the anxiolytic properties of cannabinoid type 1 receptor (CB1R) activation and transient potential vanilloid type 1 channel (TRPV1) inhibition. Arachidonoyl serotonin (AA-5-HT), a dual fatty acid amide hydrolase and TRPV1 inhibitor provides an efficient means of modulating these systems. We therefore examined the effects of AA-5-HT on anxiety- and fear-like behaviors in male low (C57BL/6J; [B6]) and high (BALB/cJ; [BCJ]) anxiety mice in light/dark box (LDB), open-field (OF), and fear extinction (FE) paradigms. AA-5-HT (1 mg/kg) administration did not affect anxiety-related behaviors in the …