Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Entire DC Network
Systemic Oxytocin Administration Alters Mesolimbic Dopamine Relase, Mary Kathlyn Estes
Systemic Oxytocin Administration Alters Mesolimbic Dopamine Relase, Mary Kathlyn Estes
Electronic Theses and Dissertations
Growing research indicates oxytocin may be involved in relieving anxiety and attenuating the rewarding effects of psychostimulants. The present study investigated the effects of subchronic oxytocin treatments on mesolimbic dopamine transmission in areas associated with anxiety (amygdala) and addiction (nucleus accumbens, NAc). Using in vivo fixed potential amperometry, stimulation-evoked dopamine release was recorded either in the amygdala or NAc in oxytocin pretreated mice. During dopamine recordings, mice received a drug challenge of either oxytocin, the dopamine reuptake blocker nomifensine (psychostimulant), or saline. In the amygdala, dopamine release was decreased following the oxytocin challenge but only in oxytocin pretreated mice. In …
Examining Cerebellar Modulation Of Mesolimbic Dopamine Transmission Using Fixed Potential Amperometry, Zade Ramses Holloway
Examining Cerebellar Modulation Of Mesolimbic Dopamine Transmission Using Fixed Potential Amperometry, Zade Ramses Holloway
Electronic Theses and Dissertations
Elucidating how dopamine neurons operate regularly in aspects of neurochemical release and in pathological systems is essential for understanding their role in behavior, drug treatment, and disease. Fixed-potential amperometry (FPA) combined with carbon fiber microelectrodes has proven to be effective at probing these dynamic microsystems and precisely describing the regulatory mechanisms that govern dopamine neurotransmission. To date, we have utilized FPA to: a) observe and quantify differences in the neurochemical profile of phasic dopamine release in major dopaminergic afferents including the striatum, nucleus accumbens (NAc), amygdala, and prefrontal cortex through stimulation of the medial forebrain bundle (MFB), b) provide evidence …