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Comparison Of Dietary And Caloric Restriction Models On Insulin Sensitivity In Young Mice, Jade Leanna Caldwell
Comparison Of Dietary And Caloric Restriction Models On Insulin Sensitivity In Young Mice, Jade Leanna Caldwell
Electronic Theses and Dissertations
Background: Various forms of fasting can result in improvements in insulin sensitivity. Objective: Compare the effects of various fasting models on measures of insulin sensitivity in young male C57BL/6 mice. Methods: 60 mice were assigned to the following groups: HF, CHOW, SWITCH, DF, CR, TRF, and ADF for 8 weeks, following a 6 week lead-in period of ad libitum HF consumption. Fasting blood glucose (mg/dL) and insulin (ng/mL) were measured and HOMA-IR, determined. Glucose tolerance tests were performed to determine glucose clearance pre- and post-intervention. Results: Compared to the HF ad libitum group, all groups displayed significantly lower fasting glucose, …
A Comparison Of Dietary And Caloric Restriction Models On Measures Of Body Composition And Physical Performance In Young Mice, Nicholas John Grayson Smith
A Comparison Of Dietary And Caloric Restriction Models On Measures Of Body Composition And Physical Performance In Young Mice, Nicholas John Grayson Smith
Electronic Theses and Dissertations
Background: In recent years, time-restricted feeding, alternate day fasting, and the Daniel Fast have garnered attention as potential dietary interventions to combat obesity. Objective: To compare the effects of various dietary models on measures of body composition and physical performance in male C57BL/6 mice. Methods: 60 young C57BL/6 male mice were assigned to a diet of time-resticted feeding, alternate day fasting, the Daniel Fast, caloric restriction, a high-fat diet, or a standard rodent chow for 8 weeks. Body composition and run time to exhaustion were determined. Results: Compared to the high-fat ad libitum grounp, all groups displayed significantly less weight …