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Will Radiation-Induced Bystander Effects Or Adaptive Responses Impact On The Shape Of The Dose Response Relationships At Low Doses Of Ionizing Radiation?, William F Morgan
Will Radiation-Induced Bystander Effects Or Adaptive Responses Impact On The Shape Of The Dose Response Relationships At Low Doses Of Ionizing Radiation?, William F Morgan
Dose-Response: An International Journal
Radiation induced bystander effects and adaptive responses are two phenomena that modulate cellular responses to low doses of ionizing radiation. Bystander effects generally exaggerate the effects of low doses of radiation by eliciting detrimental effects in nonirradiated cells, thus making the target for radiation effects greater than the volume irradiated. Adaptive responses on the other hand indicate that low doses of radiation can reduce damage induced by a second challenging dose. The potential impact of these two low dose effects on the shape of the dose response relationship will be discussed.
Adaptive And Bystander Responses In Human And Rodent Cell Cultures Exposed To Low Level Ionizing Radiation: The Impact Of Linear Energy Transfer, Sonia M De Toledo, Edouard I Azzam
Adaptive And Bystander Responses In Human And Rodent Cell Cultures Exposed To Low Level Ionizing Radiation: The Impact Of Linear Energy Transfer, Sonia M De Toledo, Edouard I Azzam
Dose-Response: An International Journal
To understand the potential impact on risk from exposure to low-level ionizing radiation, we have investigated the modulation of gene expression, induction of DNA damage and of neoplastic transformation in human or rodent cells derived from cultures exposed in vitro to low dose γ-rays (a low linear energy transfer radiation) or very low fluences of α-particles (a high linear energy transfer radiation). Pre-exposure of cells to a low γ-ray dose protected cells from the DNA damaging and killing effects induced by a subsequent acute challenge exposure to γ-rays. Furthermore, a low dose chronic exposure to γ-rays decreased the frequency of …
Development Of An In Vivo Assay For Detection Of Nontargeted Radiation Effects, Colin Seymour, Carmel Mothersill
Development Of An In Vivo Assay For Detection Of Nontargeted Radiation Effects, Colin Seymour, Carmel Mothersill
Dose-Response: An International Journal
An adaptive response may be defined as the effect of a small priming dose of radiation modifying the anticipated cellular response of the same tissues so as to alter the predicted response to a larger dose of radiation. We and others have demonstrated that at low radiation doses (less than 0.5 Gy) the lethal and mutational effect of the radiation is mainly, possibly entirely, due to the non-targeted effects. This is the dose range for priming doses in adaptive response protocols. In an associated presentation from our group, we demonstrate that the adaptive response may be explicable as a non …
In Vivo Mutagenic Effect Of Very Low Dose Radiation, Pamela J Sykes, Tanya K Day, Sarah J Swinburne, Joanne M Lane, Alexander A Morley, Anthony M Hooker, Madhava Bhat
In Vivo Mutagenic Effect Of Very Low Dose Radiation, Pamela J Sykes, Tanya K Day, Sarah J Swinburne, Joanne M Lane, Alexander A Morley, Anthony M Hooker, Madhava Bhat
Dose-Response: An International Journal
Almost all of our knowledge about the mutational effect of radiation has come from high dose studies which are generally not relevant to public exposure. The pKZ1 mouse recombination mutagenesis assay enables study of the mutational effect of very low doses of low LET radiation (μGy to cGy range) in a whole animal model. The mutational endpoint studied is chromosomal inversion which is a common mutation in cancer. We have observed 1) a non-linear dose response of induced inversions in pKZ1 mice exposed to a wide dose range of low LET radiation, 2) the ability of low priming doses to …