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Cavitation Induced Fracture Of Intact Brain Tissue, Carey E. Dougan, Zhaoqiang Song, Hongo Fu, Alfred J. Crosby, Shengqiang Cai, Shelly Peyton
Cavitation Induced Fracture Of Intact Brain Tissue, Carey E. Dougan, Zhaoqiang Song, Hongo Fu, Alfred J. Crosby, Shengqiang Cai, Shelly Peyton
Chemical Engineering Faculty Publication Series
Nonpenetrating traumatic brain injuries (TBI) are linked to cavitation. The structural organization of the brain makes it particularly susceptible to tears and fractures from these cavitation events, but limitations in existing characterization methods make it difficult to understand the relationship between fracture and cavitation in this tissue. More broadly, fracture energy is an important, yet often overlooked, mechanical property of all soft tissues. We combined needle-induced cavitation (NIC) with hydraulic fracture models to induce and quantify fracture in intact brains at precise locations. We report here the first measurements of the fracture energy of intact brain tissue that range from …
A Poly(Ethylene Glycol) Three-Dimensional Bone Marrow Hydrogel, Lauren E. Jansen, Hyuna Kim, Christopher L. Hall, Thomas P. Mccarthy, Michael J. Lee, Shelly R. Peyton
A Poly(Ethylene Glycol) Three-Dimensional Bone Marrow Hydrogel, Lauren E. Jansen, Hyuna Kim, Christopher L. Hall, Thomas P. Mccarthy, Michael J. Lee, Shelly R. Peyton
Chemical Engineering Faculty Publication Series
Three-dimensional (3D) hydrogels made from synthetic polymers have emerged as in vitro cell culture platforms capable of representing the extracellular geometry, modulus, and water content of tissues in a tunable fashion. Hydrogels made from these otherwise non-bioactive polymers can be decorated with short peptides derived from proteins naturally found in tissues to support cell viability and direct phenotype. We identified two key limitations that limit the ability of this class of materials to recapitulate real tissue. First, these environments typically display between 1 and 3 bioactive peptides, which vastly underrepresents the diversity of proteins found in the extracellular matrix …
Materials-Driven Approaches To Understand Extrinsic Drug Resistance In Cancer, Pritchard Justin, Michael Lee, Shelly Peyton
Materials-Driven Approaches To Understand Extrinsic Drug Resistance In Cancer, Pritchard Justin, Michael Lee, Shelly Peyton
Chemical Engineering Faculty Publication Series
Metastatic cancer has a poor prognosis, because it is broadly disseminated and associated with both intrinsic and acquired drug resistance. Critical unmet needs in effectively killing drug resistant cancer cells include overcoming the drug desensitization characteristics of some metastatic cancers/lesions, and tailoring therapeutic regimens to both the tumor microenvironment and the genetic profiles of the resident cancer cells. Bioengineers and materials scientists are developing technologies to determine how metastatic sites exclude therapies, and how extracellular factors (including cells, proteins, metabolites, extracellular matrix, and abiotic factors) at metastatic sites significantly affect drug pharmacodynamics. Two looming challenges are determining which feature, or …
Linear Viscoelasticity And Time—Alcohol Superposition Of Chitosan/Hyaluronic Acid Complex Coacervates, Juanfeng Sun, Jessica D. Schiffman, Sarah L. Perry
Linear Viscoelasticity And Time—Alcohol Superposition Of Chitosan/Hyaluronic Acid Complex Coacervates, Juanfeng Sun, Jessica D. Schiffman, Sarah L. Perry
Chemical Engineering Faculty Publication Series
Complex coacervation is an associative liquid−liquid phase separation phenomenon resulting from the complexation of oppositely charged macroions. While it is well-known that the phase behavior and rheological character of the resulting coacervates can vary as a function of the identity of the various species present (i.e., macroions, salt, and solution conditions), the effect of solvent quality has been rarely studied. Here, the effect of adding small amounts of either methanol or ethanol to complex coacervates of the natural polymers chitosan and hyaluronic acid is described. The effect of cosolvent addition on the phase behavior and linear viscoelasticity of the resulting …