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University of Louisville

2018

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Studying Galaxy Troughs And Ridges Using Weak Gravitational Lensing With The Kilo-Degree Survey, Margot M. Brouwer, Vasiliy Demchenko, Joachim Harnois-Déraps, Maciej Bilicki, Catherine Heymans, Henk Hoekstra, Konrad Kuijken, Mehmet Alpaslan, Sarah Brough, Yan Chuan Cai, Marcus V. Costa-Duarte, Andrej Dvornik, Thomas Erben, Hendrik Hildebrandt, Benne W. Holwerda, Peter Schneider, Cristóbal Sifón, Edo Van Uitert Dec 2018

Studying Galaxy Troughs And Ridges Using Weak Gravitational Lensing With The Kilo-Degree Survey, Margot M. Brouwer, Vasiliy Demchenko, Joachim Harnois-Déraps, Maciej Bilicki, Catherine Heymans, Henk Hoekstra, Konrad Kuijken, Mehmet Alpaslan, Sarah Brough, Yan Chuan Cai, Marcus V. Costa-Duarte, Andrej Dvornik, Thomas Erben, Hendrik Hildebrandt, Benne W. Holwerda, Peter Schneider, Cristóbal Sifón, Edo Van Uitert

Faculty Scholarship

We study projected underdensities in the cosmic galaxy density field known as 'troughs', and their overdense counterparts, which we call 'ridges'. We identify these regions using a bright sample of foreground galaxies from the photometric Kilo-Degree Survey (KiDS), specifically selected to mimic the spectroscopic Galaxy And Mass Assembly survey. Using background galaxies from KiDS, we measure the weak gravitational lensing profiles of the troughs/ridges. We quantify the amplitude of their lensing strength A as a function of galaxy density percentile rank P and galaxy overdensity δ, and find that the skewness in the galaxy density distribution is reflected in the …

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Perceived Public Opinion Vs. Actual Public Opinion And Media's Influence., Sarah Carey Dec 2018

Perceived Public Opinion Vs. Actual Public Opinion And Media's Influence., Sarah Carey

College of Arts & Sciences Senior Honors Theses

This paper examines the extent of polarization in the United States in the current political climate. It was predicted that individual beliefs would be less polarized than news media makes it seem because while the political parties are moving further toward the poles, there is no evidence to suggest that individuals are doing the same. Using Berkeley’s Survey Documentation and Analysis tool, data from the American National Election Studies (ANES) was analyzed to test this premise. The ANES measured individuals’ party identification. The analysis focused on those who identify as Democrats, Republicans, and Independents. The survey then asked those same …

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Mentee And Mentor Teacher Perspectives On The Effectiveness Of School-Based Mentorship In High-Poverty, Low-Performing Schools., Amanda Leigh Santos-Colon, Carlisha Smith Kent Dec 2018

Mentee And Mentor Teacher Perspectives On The Effectiveness Of School-Based Mentorship In High-Poverty, Low-Performing Schools., Amanda Leigh Santos-Colon, Carlisha Smith Kent

College of Education & Human Development Capstone Projects

This capstone intends to seek a teacher’s perspective on the effectiveness of school-based mentorship in a high-poverty, low-performing school setting. The first study investigates the perspectives of new teachers, while the second study focuses on the perspectives of the mentor teachers. When new teachers complete the undergraduate program, they become certified teachers but have never actually had the opportunity to be alone in a classroom with up to thirty students. New teachers are often prepared to teach the curriculum but unprepared for the student behavior and classroom management. Furthermore, teachers may be assigned a mentor, but the mentor may lack …

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Conquerors Or Cowards: The Role Of The Kentucky Mounted Militia In The Indian Wars From 1768 To 1841., Joel Anderson Dec 2018

Conquerors Or Cowards: The Role Of The Kentucky Mounted Militia In The Indian Wars From 1768 To 1841., Joel Anderson

Electronic Theses and Dissertations

The thesis argues that Kentuckians developed the myth that the Kentucky Mounted Volunteers were the most effective troops to fight Native American warriors in the Northwest Indian War of 1790 to 1794 and the War of 1812. The idea that these troops were the best fighters originated in the decades following the War of 1812 as Kentuckians generated a communal history. Residents of the state listened to orators mythologize the successes of mounted Kentuckians in battle, while remembering the foot militia for their sacrifices rather than their shortcomings.

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Fostering Compassionate Care For Persons With Alzheimer's Disease In Nursing Facilities., Sam Gilbert Cotton Dec 2018

Fostering Compassionate Care For Persons With Alzheimer's Disease In Nursing Facilities., Sam Gilbert Cotton

Electronic Theses and Dissertations

The aim of this dissertation study was to examine the impact of the implementation of a new Compassionate Care (CC) curriculum on the quality of care provided by Certified Nursing Assistants (CNAs) to residents with Alzheimer’s disease (AD). More specifically, this dissertation used Kirkpatrick’s model of evaluation to assess the reactions, learning, and behavior change of the CNAs exposed to the curriculum, and ultimately the impact of the curriculum on the stress levels of residents with AD. To accomplish this, we had two studies that aligned with the Kirkpatrick model of evaluation. For Study #1, the evaluation of the compassionate …

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Process-Property-Microstructure Relationships In Laser-Powder Bed Fusion Of 420 Stainless Steel., Subrata Deb Nath Dec 2018

Process-Property-Microstructure Relationships In Laser-Powder Bed Fusion Of 420 Stainless Steel., Subrata Deb Nath

Electronic Theses and Dissertations

Laser-powder bed fusion (L-PBF) is an additive manufacturing technique for fabricating metal components with complex design and customized features. However, only a limited number of materials have been widely studied using L-PBF. AISI 420 stainless steel, an alloy with a useful combination of high strength, hardness, and corrosion resistance, is an example of one such material where few L-PBF investigations have emerged to date. In this dissertation, L-PBF experiments were conducted using 420 stainless steel powders to understand the effects of chemical composition, particle size distribution and processing parameters on ensuing physical, mechanical and corrosion properties and microstructure in comparison …

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The Unequal City: The Mass Criminalization Of The Urban Poor., Elizabeth Michele Jones Dec 2018

The Unequal City: The Mass Criminalization Of The Urban Poor., Elizabeth Michele Jones

Electronic Theses and Dissertations

Exploring and understanding the widespread use of arrests and incarceration in urban neighborhoods of concentrated poverty is the subject of this dissertation. The research addresses gaps in theoretical debates about the causes of mass criminalization that position the phenomenon as the result of either neoliberalism or racism. In addition, the dissertation explores the impact of mass criminalization on urban citizenship. Urban citizenship is a theoretical frame that considers the substance of the economic, social, political, and mobility dimensions of city life. The research methodology is a case study of two impoverished neighborhoods in the city of Louisville, Kentucky that incorporates …

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Student Voices: African American High School Seniors' Perception Of Culturally Responsive Teaching., Whitney M. Stewart Dec 2018

Student Voices: African American High School Seniors' Perception Of Culturally Responsive Teaching., Whitney M. Stewart

Electronic Theses and Dissertations

This dissertation examined African-American high school seniors’ perceptions of culturally responsive teaching in one public high school within a large urban public-school district in the southeastern region of the United States. It begins with a brief historical overview on the plight of African-Americans in the US public education system and how public school educators have failed to leverage Afrocultural learning orientations as an asset to educate and increase the academic achievement of African-American students in classrooms. The Philosophical Aspects of Cultural Difference Framework (Nichols, 1986, 1995) will guide this dissertation study. The latter part of the dissertation reveals that a …

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Evaluation Of The Predictive Ability Of A Screening Instrument Used To Diagnose Co-Occurrence Of Anxiety In Children With High-Functioning Autism., Austin Zachary Dec 2018

Evaluation Of The Predictive Ability Of A Screening Instrument Used To Diagnose Co-Occurrence Of Anxiety In Children With High-Functioning Autism., Austin Zachary

Electronic Theses and Dissertations

Anxiety has shown to have a high co-occurrence in children with Autism Spectrum Disorder (ASD), but has been difficult to co-diagnose. This study analyzed the ability of the Screen for Child Anxiety-Related Emotional Disorders (SCARED) to predict positive ASD screenings of the Social Responsiveness Scale (SRS). Parents and children ages 8 to 18 years (N = 100) were screened for anxiety using the SCARED and autism using the SRS. Moderate correlation was found between parent-reported SCARED and positive screening of the SRS (r = .579), with weak correlation found in the child-reported SCARED (r = .105). LASSO regression was conducted …

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Present But Not Accounted For: A Phenomenological Study Of Gifted African American Males., Ronda Elizabeth George Dec 2018

Present But Not Accounted For: A Phenomenological Study Of Gifted African American Males., Ronda Elizabeth George

Electronic Theses and Dissertations

The purpose of this research study was to explore the lived experiences of gifted African American males in grades 6-8. Specifically, the study examined how gifted African American males perceived and understood their participation in a gifted program and how their sense of self-efficacy shaped their disposition and approach toward academic persistence. Much of the literature published on the social, emotional, and academic success of gifted African American males has focused on college-aged students, therefore the current study is crucial in contributing to the body of knowledge on African American males, in particular, those identified as gifted during early adolescence …

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Student Perception Of The Effects Of Out Of School Suspension On Academic Motivation., Dawn Boone Roseberry Dec 2018

Student Perception Of The Effects Of Out Of School Suspension On Academic Motivation., Dawn Boone Roseberry

Electronic Theses and Dissertations

Historically, the response to rule violations and misbehavior in schools was to punish students by using methods such as exclusionary discipline. Exclusionary discipline may lead to poor academic outcomes for the student, increased likelihood of dropping out of school, and an introduction to the criminal justice system (Cueller and Markowitz, 2015). Being suspended from school also increases the chances a student will feel disconnected, intensify conflict with adults, and impact a youth’s choice to engage in criminal activities (Skiba et al., 2006). Researchers have concluded that suspension is also a predictor of future suspensions, not a deterrent (Rafaele & Mendez, …

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The Emperor's New Clothes: How The New Atheists Are Reminding The Humanities Of Their Place And Purpose In Society., David Ira Buckner Dec 2018

The Emperor's New Clothes: How The New Atheists Are Reminding The Humanities Of Their Place And Purpose In Society., David Ira Buckner

Electronic Theses and Dissertations

This dissertation will examine the social and intellectual impact of the so-called “New Atheism” as evidenced by the writings and public careers of its four principal protagonists: evolutionary biologist Richard Dawkins, philosopher Daniel Dennett, journalist Christopher Hitchens, and neuroscientist Sam Harris. I will argue that the New Atheists together provide an account of reality philosophically superior to that of theism, including those superficially sophisticated variations espoused in the writings of scholars William Lane Craig, John Lennox, Allister McGrath, Alvin Plantinga, etc. Yet, even if this were not so, I would still contend that the accessible, informative, and provocative style of …

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North American Indigenous Collection And Curation And Its Impact On Market Arts., Adelaide Mccomb Dec 2018

North American Indigenous Collection And Curation And Its Impact On Market Arts., Adelaide Mccomb

Electronic Theses and Dissertations

This thesis examines the history of two North American Indigenous groups, those belonging to the Great Plains and the Arctic, and observes how settler-colonial influence determined the collection and curation of arts and artifacts in these areas. This art includes a mention of pre-Colombian works, but focuses predominantly on works being made after “first-contact” through the contemporary ear. The paper addresses the effect imperialist history has had on the development of Indigenous art markets, and how institutions such as museums may address them through ethical practices, and efforts to decolonize museum spaces.

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Lead And Crime: An Ecological Study Between Lead Contaminated Topsoil And Violent Crime., Brian Guinn Dec 2018

Lead And Crime: An Ecological Study Between Lead Contaminated Topsoil And Violent Crime., Brian Guinn

Electronic Theses and Dissertations

Lead is a known neurotoxicant. Human exposure to lead comes primarily through environmental exposures, including remnant lead paint, lead contaminated topsoil and lead contaminated water. Prenatal and early life lead exposure has been associated with numerous neurocognitive and neuropsychiatric disorders. This dissertation presents findings from an ecological study which evaluated the geospatial association between topsoil lead content and the incidence of FBI designated violent crime in Jefferson County, Kentucky. A total of 412 topsoil samples were collected along roadways (n=300) and from Louisville Metro Parks (n=112). Jefferson County crime data was obtained from the Louisville Metro Police Department – Crime …

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Transcending The Panels: Varieties Of Experience And Selfhood In Comics., Will D. Simpson Dec 2018

Transcending The Panels: Varieties Of Experience And Selfhood In Comics., Will D. Simpson

Electronic Theses and Dissertations

In this dissertation, I argue that the typical formal features of American comics over the past century have influenced the types of narrative content that tend to be communicated by said medium. I argue that the types of reader experiences that are afforded by the comics form, in part, shape the types of stories told through comics. The experiences that result from the ways we engage perceptually, cognitively, emotionally, and conceptually with comics imply a certain view of selfhood that is potentially subversive in the context of American cultural religiosity and spirituality. The formal features of comics, and the resulting …

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Synthesis And Characterization Of Targeted Bar Encapsulated Polylactic-Co-Glycolic Acid Nanoparticles To Inhibit Porphyromonas Gingivalis Biofilm Formation., Ranjith Radha Krishnan Dec 2018

Synthesis And Characterization Of Targeted Bar Encapsulated Polylactic-Co-Glycolic Acid Nanoparticles To Inhibit Porphyromonas Gingivalis Biofilm Formation., Ranjith Radha Krishnan

Electronic Theses and Dissertations

Periodontal disease is one of the most prevalent infectious diseases worldwide. Between 30-50% of the global adult population suffers from periodontal disease. Some form of periodontitis is present in 46% of American adults, corresponding to annual expenditures in excess of 14 billion dollars for treatment and prevention. Current treatments for periodontal diseases involve mechanical removal of plaque, correction of risk factors, gingival surgery and/or antibiotic therapy. To our knowledge there is no effective therapeutic approach that aims to limit pathogen colonization of the oral biofilm or re-colonization after treatment. Interaction of the pathogen Porphyromonas gingivalis with oral streptococci is critical …

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Landmine Detection Using Semi-Supervised Learning., Graham Reid Dec 2018

Landmine Detection Using Semi-Supervised Learning., Graham Reid

Electronic Theses and Dissertations

Landmine detection is imperative for the preservation of both military and civilian lives. While landmines are easy to place, they are relatively difficult to remove. The classic method of detecting landmines was by using metal-detectors. However, many present-day landmines are composed of little to no metal, necessitating the use of additional technologies. One of the most successful and widely employed technologies is Ground Penetrating Radar (GPR). In order to maximize efficiency of GPR-based landmine detection and minimize wasted effort caused by false alarms, intelligent detection methods such as machine learning are used. Many sophisticated algorithms are developed and employed to …

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Influence Of Bilberry-Derived Anthocyanidins On Key Regulators Of Colorectal Cancer Development., Ashley M. Mudd Dec 2018

Influence Of Bilberry-Derived Anthocyanidins On Key Regulators Of Colorectal Cancer Development., Ashley M. Mudd

Electronic Theses and Dissertations

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths within the United States. A variety of factors including exposure to environmental carcinogens, such as benzo[a]pyrene (B[a]P), dysbiosis of the gut microbiome and hereditary influences, including APC mutations, have been shown to lead to an increased risk of developing colorectal cancer. Given the recent alarming rise in cases of colorectal cancer diagnosed in individuals under the age of 40, further insight into developing novel and effective prevention and treatment strategies are warranted. The family of plant pigments known as the anthocyanins has been identified with …

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Common Ground, Diverging Paths: Eighteenth-Century English And French Landscape Painting., Jessica Robins Schumacher Dec 2018

Common Ground, Diverging Paths: Eighteenth-Century English And French Landscape Painting., Jessica Robins Schumacher

Electronic Theses and Dissertations

In the early eighteenth century, both English and French artists traveled to Rome to study the great seventeenth-century landscape artists --Claude Lorrain and Nicolas Poussin in particular—at the source. The English were motivated by a combination of reverence for the ancient, classical world, an associative imagination and a burgeoning competitive art market. The French, by an equal regard for antiquity and the pragmatic desire to complete the requirements of the monopolistic French Academy. While English landscape painting evolved away from the idealism of Claude to a modern naturalism imbued with the artist’s subjective response to a visual experience, French landscape …

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Particulate Hexavalent Chromium Does Not Induce Centrosome Amplification In Sperm Whale And Bowhead Whale Cells., Jennifer Haruka Toyoda Dec 2018

Particulate Hexavalent Chromium Does Not Induce Centrosome Amplification In Sperm Whale And Bowhead Whale Cells., Jennifer Haruka Toyoda

Electronic Theses and Dissertations

Hexavalent chromium [Cr(VI)] is a widespread environmental and occupational carcinogen. The mechanism of carcinogenesis remains poorly understood, but chromosome instability (CIN) is the dominant theory. How numerical CIN arises is unclear, but it correlates with centrosome amplification. Both phenotypes are hallmarks of cancers, early events in carcinogenesis, and have been shown to occur after Cr(VI) exposure to human skin and lung fibroblasts. In this study, we investigate numerical CIN and centrosome amplification in whale cells. Whales are our closest marine relatives, have long lifespans, and are exposed to environmental Cr(VI). Importantly, they have low cancer rates and cell culture studies …

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Epidermal Growth Factor Receptor (Egfr) Inhibition By Polychlorinated Biphenyls Contributes To Non-Alcoholic Fatty Liver Disease (Nafld)., Josiah Hardesty Dec 2018

Epidermal Growth Factor Receptor (Egfr) Inhibition By Polychlorinated Biphenyls Contributes To Non-Alcoholic Fatty Liver Disease (Nafld)., Josiah Hardesty

Electronic Theses and Dissertations

This dissertation describes how poly-chlorinated biphenyls (PCBs) exacerbate the pathogenesis of non-alcoholic fatty liver disease (NAFLD). While PCBs were banned in 1979, they still persist in contaminated biota, including food, and are detected in human plasma and adipose. The body burden of PCBs is associated with elevation of liver enzymes and necrosis markers in humans, characteristic of NAFLD. PCB exposure in high-fat diet fed mice leads to steatohepatitis that recapitulate the findings seen in exposed humans. The global estimate of people diagnosed with NAFLD is up to 1 in 4 people, unrelated to dietary or genetic factors. The hepatic mechanisms …

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Understanding The Relationship Between Anti-Transgender Bias, Non-Affirmation, And Post-Traumatic Stress: A Model Of Internalized Transphobia-Mediated Post-Traumatic Stress., Sebastian Mitchell Barr Dec 2018

Understanding The Relationship Between Anti-Transgender Bias, Non-Affirmation, And Post-Traumatic Stress: A Model Of Internalized Transphobia-Mediated Post-Traumatic Stress., Sebastian Mitchell Barr

Electronic Theses and Dissertations

Transgender people’s increased risk for negative mental health outcomes, when compared to cisgender peers or the general public, has been well documented in the psychological literature. Researchers have begun to establish empirical support for a relationship between anti-transgender bias, non-affirmation of gender identity, internalized transphobia, and other transgender-specific minority stressors. Although little work has explored the mechanisms of this relationship, some psychologists have proposed conceptualizing these factors as potentially traumatic experiences and understanding the poor mental health outcomes as manifestations of complex post-traumatic stress. In this dissertation, I examine whether there is empirical support for this framework by evaluating the …

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Substellar And Low-Mass Dwarf Identification With Near-Infrared Imaging Space Observatories, Benne W. Holwerda, J. S. Bridge, R. Ryan, M. A. Kenworthy, N. Pirzkal, M. Andersen, S. Wilkins, R. Smit, S. R. Bernard, T. Meshkat, R. Steele, R. C. Bouwens Dec 2018

Substellar And Low-Mass Dwarf Identification With Near-Infrared Imaging Space Observatories, Benne W. Holwerda, J. S. Bridge, R. Ryan, M. A. Kenworthy, N. Pirzkal, M. Andersen, S. Wilkins, R. Smit, S. R. Bernard, T. Meshkat, R. Steele, R. C. Bouwens

Faculty Scholarship

Aims. We aim to evaluate the near-infrared colors of brown dwarfs as observed with four major infrared imaging space observatories: the Hubble Space Telescope (HST), the James Webb Space Telescope (JWST), the Euclid mission, and the WFIRST telescope. Methods. We used the SPLAT SPEX/ISPEX spectroscopic library to map out the colors of the M-, L-, and T-type dwarfs. We have identified which color-color combination is optimal for identifying broad type and which single color is optimal to then identify the subtype (e.g., T0-9). We evaluated each observatory separately as well as the narrow-field (HST and JWST) and wide-field (Euclid and …

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The Effects Of Musical Training On The Well-Being Of Older Adults., Brianna Nicole Berry Dec 2018

The Effects Of Musical Training On The Well-Being Of Older Adults., Brianna Nicole Berry

College of Arts & Sciences Senior Honors Theses

Objective. The current study sought to examine the effects of early musical training on the quality of life of older adults. Method. 58 older adults, at least 65 years old, were divided into three groups based on their levels of musicianship: non-musicians, low-activity musicians (less than ten years of lessons), and high-activity musicians (more than ten years of lessons). Self-report questionnaires were given to determine musical training and other factors such as physical activities. Quality of life was measured by the Quality of Life-AD, a 13-item survey. Results. The differences between level of musicianship and quality of life were statistically …

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Neural Correlates Relating To Executive Function, Intelligence, And Anxiety., Sarah K L'Heureux Dec 2018

Neural Correlates Relating To Executive Function, Intelligence, And Anxiety., Sarah K L'Heureux

College of Arts & Sciences Senior Honors Theses

The human brain is a complex organ responsible for not only perceiving and sensing information in one’s environment, but also integrating and analyzing these details in a way that will allow an individual to comprehend the material. Scientists for centuries have been curious as to why people process their emotions and thoughts differently, resulting in unique and varied behavior. The manner in which a person comprehends information and whether or not they feel anxious as a result, may be connected to their intellectual and functional capacity. Human intelligence and the ability to function at a high level may be related …

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Coagulation Factor Xiiia: Biochemical Properties Underlying Physiological Function., Boris Anokhin Dec 2018

Coagulation Factor Xiiia: Biochemical Properties Underlying Physiological Function., Boris Anokhin

Electronic Theses and Dissertations

Factor XIIIA (FXIIIA) is a transglutaminase that crosslinks intra- and extracellular protein substrates. The oligomeric state of active FXIIIA remains controversial, and the present work commenced with addressing this issue. The results of size exclusion chromatography and analytical ultracentrifugation confirmed a dimeric state for zymogen and, for the first time, indicated a monomeric state for the active FXIIIA in solution. Comparing sedimentation properties of proteolytically and nonproteolytically activated FXIIIA suggested conformational and functional differences between the two forms. Those differences were further assessed in a series of catalytic activity studies. Kinetic analysis revealed affinity for the glutamine substrate was higher …

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Functional Consequence Of Psat1 Association On Pkm2'S Inherent Enzymatic Activity., Alexis Avidan Vega Dec 2018

Functional Consequence Of Psat1 Association On Pkm2'S Inherent Enzymatic Activity., Alexis Avidan Vega

Electronic Theses and Dissertations

Pyruvate kinase M2 (PKM2) is predominantly found in tumors, where it allows the cancer cell to adapt to metabolic conditions through allosteric regulation of its activity. We recently discovered that phosphoserine aminotransferase 1 (PSAT1) associates with and activates PKM2. Here, I sought to affirm PSAT1's ability to increase PKM2 activity through kinetic and association studies of wild-type or mutant PKM2 enzymes. I demonstrate that His-tagged WT and mutant PKM2 enzymes are active, exhibit different kinetics, yet cannot be activated by PSAT1. Comparison studies using untagged WT PKM2 suggest that inclusion of the His-tag disrupts PSAT1 association. In support, pull-down strategies …

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Association Between Cigarette Smoking And Ovarian Reserve Among Women Seeking Fertility Treatment With Effect Modification By Race And Nat2 Genotype., Islamiat A. Oladipupo Dec 2018

Association Between Cigarette Smoking And Ovarian Reserve Among Women Seeking Fertility Treatment With Effect Modification By Race And Nat2 Genotype., Islamiat A. Oladipupo

Electronic Theses and Dissertations

Cigarette smoking in women has been associated with adverse reproductive outcomes such as reduced ovarian reserve, poorer in vitro fertilization (IVF) outcomes and increased adverse pregnancy outcomes. This study examined the association of smoking with ovarian reserve in a cross-sectional study of women seeking fertility treatment, and potential effect modification by race and NAT2 acetylator phenotype. Data from 265 women from the Louisville Tobacco Smoke, Genetic Susceptibility, and Infertility (LOUSSI) Study were analyzed. A total of 265 women were recruited through a single infertility clinic between September 2016 and June 2018. Information on current smoking status was assessed using a …

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The Migration And Developmental Remodeling Of Intrinsic Interneurons In Visual Thalamus And The Role Of Retinal Signaling., Naomi E. Charalambakis Dec 2018

The Migration And Developmental Remodeling Of Intrinsic Interneurons In Visual Thalamus And The Role Of Retinal Signaling., Naomi E. Charalambakis

Electronic Theses and Dissertations

The dorsal lateral geniculate nucleus (dLGN) of the mouse is a model system to study the development of thalamic circuitry. While most studies focus on relay neurons of dLGN, little is known about the factors regulating the development of the other principal cell type, intrinsic interneurons. To date, the targeting and migratory path of dLGN interneurons as well as their morphological development remains unclear. Here we examined whether the migration, structure, and function of interneurons relies on retinal signaling. We took a loss-of-function approach and crossed GAD67-GFP mice, which express green fluorescent protein (GFP) in dLGN interneurons, with math5 nulls …

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Frederic Lindley Morgan : Gentleman Architect And Reluctant Modernist., Lisa Grace Carpenter Dec 2018

Frederic Lindley Morgan : Gentleman Architect And Reluctant Modernist., Lisa Grace Carpenter

Electronic Theses and Dissertations

Frederic Lindley Morgan, a major architect in Louisville,Kentucky, was born in Loda,Illinois in 1889. Morgan, in partnerships with other architects throughout his career, designed a variety of projects including homes, schools, churches, commercial buildings and even an airport. Morgan worked up until he died, in 1970, in Louisville. What makes Mr.Morgan's work distinctive is not the timelessness of his designs, nor the fact he was dubbed "Louisville's society architect," nor his lengthy 50 plus year career. Morgan had the ability to take his training, in combination with his talent and savvy business sense, and work successfully in a variety of …

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