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Electrospun Fibers And Nanoparticles For The Prevention Of Sexually Transmitted Infections., Kevin Michael Tyo
Electrospun Fibers And Nanoparticles For The Prevention Of Sexually Transmitted Infections., Kevin Michael Tyo
Electronic Theses and Dissertations
Human immunodeficiency virus-1 (HIV-1) and herpes simplex virus 2 (HSV-2) affect hundreds of millions of people worldwide, with women disproportionately impacted by these infections. Currently, only oral pre-exposure prophylaxis (PrEP) is approved specifically for the prevention of HIV-1, but is challenged with adverse side effects associated with long-term use. Topical delivery platforms, such as gels and films, deliver agents directly to the female reproductive tract, but are limited in providing transient-release. The technology of polymeric electrospun fibers may serve as alternative topical delivery platform to the female reproductive tract. In these studies, we fabricated electrospun fibers comprised of different polymers …
The Tournament And Chivalry As Represented By Chrétien De Troyes, Marie De France, And Geoffrey Chaucer., Hailey Michelle Brangers
The Tournament And Chivalry As Represented By Chrétien De Troyes, Marie De France, And Geoffrey Chaucer., Hailey Michelle Brangers
Electronic Theses and Dissertations
It is a common belief among historians that the tournament was the ultimate expression of chivalry, as a place where knights could openly display their prowess, courtoisie, and largesse. A knight’s relationship with ladies was also crucial to measuring his chivalrousness. Despite the importance of both within chivalric knighthood, little has been done to explore their interrelation. With romance literature being the most tangible source for understanding both the tournament and a lady’s role in it, this thesis explores the relationship between the two. I begin with a brief introductory history of the tournament, establishing its war-centric foundations and touching …
An Electrochemical Instrument For The Analysis Of Heavy Metals In Water Via Anodic Stripping Coulometry For Applications In Remote Sensing., Kelsey Lynn Kaht
An Electrochemical Instrument For The Analysis Of Heavy Metals In Water Via Anodic Stripping Coulometry For Applications In Remote Sensing., Kelsey Lynn Kaht
Electronic Theses and Dissertations
From the high levels of arsenic in groundwater in Bangladesh to the lead contamination of drinking water in Flint, Michigan, there are incidents across the globe that highlight the need for a reliable instrument capable of monitoring heavy metals remotely and continuously in a variety of geographical locations. Typical instrumentation for water analysis, such as ICP and AAS, must be housed in a central lab and relies on an operator traveling to the collection site, obtaining a sample, and transporting it back to the lab. This analysis provides a snapshot of the water quality that is limited to the specific …
Non-Invasive Detection And Assessment Of Coronary Stenosis From Blood Mean Residence Times., Javad Hashemi
Non-Invasive Detection And Assessment Of Coronary Stenosis From Blood Mean Residence Times., Javad Hashemi
Electronic Theses and Dissertations
Coronary artery stenosis is an abnormal narrowing of a coronary artery caused by an atherosclerotic lesion that reduces lumen space. Fractional flow reserve (FFR) is the gold standard method to determine the severity of coronary stenosis based on the determination of rest and hyperemic pressure fields, but requires an invasive medical procedure. Normal FFR is 1.0 and FFR RT, to account for varying volume and flow rate of individual segments. BloodRT was computed in 100 patients who had undergone the pressure-wire FFR procedure, and a threshold for BloodRT was determined to assess the physiological significance of a stenosis, …
Exploring Normalization Of Deviance And Examining Factors That Predict Culture Of Safety In The Operating Room., M. Imelda Wright
Exploring Normalization Of Deviance And Examining Factors That Predict Culture Of Safety In The Operating Room., M. Imelda Wright
Electronic Theses and Dissertations
Patient safety in the operating room is a prodigious responsibility of OR nurses as the OR environment is complex and laden with risk, which increases surgical patients’ risk for adverse events. The dissertation presents the topic of patient safety in the operating room (OR), the concept of normalization of deviance, and a mixed-methods study with an exploratory sequential design that involved three phases. The dissertation comprises of five chapters. Chapter One presents an introductory overview of the salience of patient safety as well as its relevance to the unique environment of the OR. Chapter Two presents a concept analysis of …
Reaching Zero Waste: Determining The Student Perspective On Campus Food Waste., Cassie Anne Parkins
Reaching Zero Waste: Determining The Student Perspective On Campus Food Waste., Cassie Anne Parkins
Electronic Theses and Dissertations
Food waste is an ongoing problem in the complex global food system. College campuses are in a unique position to address food waste through reducing it in their own food systems and by encouraging students to develop behaviors to reduce and divert waste from landfills. In this thesis project I seek to understand how students consider food waste and their attitudes and ideas about reducing it. To this end, I observed student behaviors and waste in University of Louisville’s all-you-care-to-eat dining hall and weighed plate waste there. I conducted informational interviews with University and Aramark employees, along with semi-structured interviews …
Disentangling The Negativity Bias: 7-9-Month-Old Crawling And Non-Crawling Infants' Responses To Fearful And Angry Expressions., Katherine C. Dixon
Disentangling The Negativity Bias: 7-9-Month-Old Crawling And Non-Crawling Infants' Responses To Fearful And Angry Expressions., Katherine C. Dixon
Electronic Theses and Dissertations
Understanding the origins of the negativity bias in infancy and how it develops is important for building a complete understanding of emotion perception. The goal of the present study was to 1) examine attentional biases for emotional expressions in infants between 7-9 months of age, specifically the bias for fearful and angry expressions, 2) examine how the onset of crawling is related to these biases and what that suggests about the mechanism underlying emotion preference in infants, and 3) examine how infant expression production differs when viewing different facial expressions. Infant attention biases to fearful, angry, happy, and neutral facial …
Addressing The Problem Of Sterile Drug Injecting Supply Acquisition For People Who Inject Drugs., Barbra Ann Cave
Addressing The Problem Of Sterile Drug Injecting Supply Acquisition For People Who Inject Drugs., Barbra Ann Cave
Electronic Theses and Dissertations
This dissertation contains five chapters, including three manuscripts, covering harm reduction and some of the challenges people who inject drugs (PWID) face in their effort to reduce the risk of injection drug-related harms through sterile injecting supply acquisition and use. Chapter One discusses some background related to PWID and provides an overview of the issues addressed in this dissertation. Chapter Two includes a literature review covering the harm reduction concept, important aspects of syringe exchange programs as a harm reduction tool, and the social determinants of health model as a potential tool for future research. Chapter Three is a two-phase …
Development And Characterization Of A Biopolymer Direct-Write Process For 3d Microvascular Structures Formation., Xiaoming Fan
Development And Characterization Of A Biopolymer Direct-Write Process For 3d Microvascular Structures Formation., Xiaoming Fan
Electronic Theses and Dissertations
Engineering of bulk tissues has been limited by the lack of nutrient and waste exchange in these tissues without an adjacent capillary network. To produce microvasculature, a scaffold must be produced that provides temporary mechanical support and stimulate endothelial cell adhesion, growth, and morphogenesis into a vessel. However, current well-established techniques for producing microvasculature, such as electrospinning, are limited since they lack both the precision to control fiber placement in three-dimensional space and the ability to create fiber networks with predefined diameters to replicate the physiological microvascular progression from arteriole to capillary to venule. Our group has developed a “Direct-write” …
Help-Seeking For Cognitive Impairment By The Patient : The Role Of Self-Compassion., Allison J. Midden
Help-Seeking For Cognitive Impairment By The Patient : The Role Of Self-Compassion., Allison J. Midden
Electronic Theses and Dissertations
Older adults represent one of the fastest growing population groups with estimates predicting global growth from 617 million in 2015 to 1.6 billion in 2050. As the aged population increases, incidence of Alzheimer’s disease (AD) and other dementias will also increase. Professionals agree that early intervention is essential for therapeutic and quality of life purposes. However, many older adults wait several months or years to seek medical help after first noticing signs of cognitive impairment. The present study seeks to identify the predictors of help-seeking for cognitive impairment by an individual for him/herself and the role that self-compassion may play …
Electrochemical Determination Of Surface Area-To-Volume Ratio For Metal Nanoparticle Analysis., Jay Narayan Sharma
Electrochemical Determination Of Surface Area-To-Volume Ratio For Metal Nanoparticle Analysis., Jay Narayan Sharma
Electronic Theses and Dissertations
This dissertation describes an electrochemical approach for measuring the surface area-to-volume ratio (SA/V) of electrode-attached metal nanoparticles (NPs), which was used to analyze their size, aggregation state, and porosity. This dissertation further describes the effect of the metal NP electrode assembly method on the SA/V, which is related to metal NP catalytic activity and stability. Cyclic voltammetry (CV) in acid electrolyte followed by anodic stripping voltammetry (ASV) in KBr electrolyte allows the electrochemical measurement of the SA/V of electrode-attached Au nanospheres (NSs). In CV, the forward scan produces a thin surface Au2O3 layer on the Au NSs. …
“Pissing In The Wind”: Racially Discriminatory Economic Policies’ Impact On Today’S Banking Status, Use Of Alternative Financial Services And Health Outcomes., Gaberiel Jones Jr
“Pissing In The Wind”: Racially Discriminatory Economic Policies’ Impact On Today’S Banking Status, Use Of Alternative Financial Services And Health Outcomes., Gaberiel Jones Jr
Electronic Theses and Dissertations
Centuries of discriminatory policies and practices in the United States have created racially segregated, resource-poor urban communities. Differential benefits of banking and housing legislation were among the consequences of these policies as they contributed to drastic racial inequities in wealth. Today, racial differences in banking status and financial practices persist. However, a void exists in the literature exploring what alternative financial services (AFS) are used in lieu of banks by Black Americans, why those services are used, the thoughts and beliefs of Black Americans about the use of those services, the impact of bank locations on financial behavior patterns, and …
Gc×Gc-Ms And Parallel 2dlc-Ms Based Untargeted Metabolomics., Md Aminul Islam Prodhan
Gc×Gc-Ms And Parallel 2dlc-Ms Based Untargeted Metabolomics., Md Aminul Islam Prodhan
Electronic Theses and Dissertations
Untargeted metabolomics aims to analyze as many metabolites as possible in a biological system. Due to the vast complexity of the metabolome, bioanalytical platforms have been developed for untargeted metabolomics. While comprehensive two-dimensional gas chromatography mass spectrometry (GC×GC-MS) has been used in different scientific fields, its use in untargeted metabolomics is limited due to several challenges, such as complicated data analysis and limited accuracy of metabolite identification. Two-dimensional liquid chromatography mass spectrometry (2DLC-MS) has also been employed in untargeted metabolomics, but with limited metabolite coverage. This dissertation describes the efforts in developing new data analysis algorithms to improve the accuracy …
Education Abroad Participation: Predicting Participation Through High School Academic Record And Intent To Be Involved In College As Reported In The Freshman Survey (Tfs) And In The College Senior Survey (Css)., Elizabeth Karen Liebschutz-Roettger
Education Abroad Participation: Predicting Participation Through High School Academic Record And Intent To Be Involved In College As Reported In The Freshman Survey (Tfs) And In The College Senior Survey (Css)., Elizabeth Karen Liebschutz-Roettger
Electronic Theses and Dissertations
Globalization is a topic of great interest in higher education yet fewer than 10% of college graduates participate in a formal study abroad program. While according to The American Council on Education [ACE] (2008) data, nearly 80% of incoming first-year students intend to go abroad, the reality is most students do not. Practitioners in Education Abroad (EA) are continually looking at ways to help increase student participation in overseas programs and opportunities. The study looks at frequencies and predictor models to help determine factors that influence student participation in study abroad. The study utilized HERI’s 2009 The Freshman Survey (TFS) …
Characterization Of The Impact Of Prenatal Cigarette Smoke Exposure On Age- And Sex-Specific Sirt1-Mediated Hepatic Molecular Phenotype In C57bl/6 Mice., Kendall S. Stocke
Characterization Of The Impact Of Prenatal Cigarette Smoke Exposure On Age- And Sex-Specific Sirt1-Mediated Hepatic Molecular Phenotype In C57bl/6 Mice., Kendall S. Stocke
Electronic Theses and Dissertations
In the U.S., 7.2% of women still report having smoked at some point during pregnancy despite known risks to fetal health. Prenatal cigarette smoke exposure (CSE) in children puts them at risk for low birth weight, premature birth, and other adverse impacts on developmental and postnatal health. Children subjected to prenatal CSE have a higher risk of adulthood metabolic disease predicted by the Barker Hypothesis. The hepatic molecular phenotype associated with this risk is unknown. This dissertation characterizes the prenatal CSE-induced hepatic molecular phenotype during three key life stages. We used a murine model of prenatal CSE utilizing a Teague …
The Manipulation Of Host Transcription By The Ankh Effector Of Legionella., Juanita E. Von Dwingelo
The Manipulation Of Host Transcription By The Ankh Effector Of Legionella., Juanita E. Von Dwingelo
Electronic Theses and Dissertations
Legionella pneumophila is a Gram-negative facultative intracellular bacterium that can be found dispersed throughout freshwater environments, where it primarily parasitizes amoebae and other protozoan species. Humans are an accidental host for L. pneumophila, and infection occurs upon inhalation of aerosolized water droplets that contain the bacteria. L. pneumophila is the causative agent of Legionnaires’ Disease, which is the result of intracellular proliferation within alveolar macrophages. Pathogenesis of L. pneumophila is dependent on the Dot/Icm type 4 secretion system (T4SS) apparatus, which is comprised of 27 proteins and is responsible for translocating over 330 effector proteins into the host cell. Many …
Therapeutic Potential Of Withaferin A Against Non-Small Cell Lung Cancer., Al Hassan Kyakulaga
Therapeutic Potential Of Withaferin A Against Non-Small Cell Lung Cancer., Al Hassan Kyakulaga
Electronic Theses and Dissertations
Lung cancer is the leading cause of cancer-related deaths worldwide and in the United States. Despite recent advancements in treatment approaches, chemoresistance and metastasis remain a major therapeutic challenge. Withaferin A (WFA), a plant-derived compound has recently emerged as a promising antitumor agent. In the present study, we explored the therapeutic potential of WFA against advanced NSCLC. Briefly, WFA was evaluated for its efficacy, toxicity and pharmacokinetic properties against advanced NSCLC using in vitro and in vivo models. Two human NSCLC cell lines, H1299 and A549 were used in cell culture to determine the anticancer properties of WFA. Repeat dose …
It's A Mad World After All: The Influence Of Stoic Thought In Goya's Los Caprichos., Jennifer Anne Steward
It's A Mad World After All: The Influence Of Stoic Thought In Goya's Los Caprichos., Jennifer Anne Steward
Electronic Theses and Dissertations
This dissertation is a study of use of the principles of Stoic rhetoric and moral psychology in Goya’s print series, Los Caprichos. The relationship between Stoic thought and the technical aspects will be explored with regard to the effects used to support the visual conceptualizations. The function of the Caprichos as a book with chapters or parts relating particular modes of perception will be addressed. The technique of aquatint employed by Goya will also be explored. The predominance of geometric forms within the composition that reflect inter-personal relationships is also presented for consideration.
Campus Recreation Inclusion For People With Disabilities: A Qualitative Investigation Of Current Inclusive Practices., Tyler C. Spencer
Campus Recreation Inclusion For People With Disabilities: A Qualitative Investigation Of Current Inclusive Practices., Tyler C. Spencer
Electronic Theses and Dissertations
This study investigated the current practices of campus recreation professionals to create inclusive campus recreation programs, services, and facilities. The researcher identified twelve campus recreation programs known by their peers and the industry to be at the forefront of providing inclusion efforts to people with disabilities. Through in-depth discussions with campus recreation practitioners at the twelve identified institutions, the investigation elicited a variety of interesting results. Utilizing the frameworks of Critical Disability Theory and Universal Design, this investigation identified how campus recreation practitioners perceive the inclusiveness of their campus recreation departments and how the campus recreation practitioners developed their inclusive …
Denkyem (Crocodile): Identity Development And Negotiation Among Ghanaian-American Millennials., Jakia Marie
Denkyem (Crocodile): Identity Development And Negotiation Among Ghanaian-American Millennials., Jakia Marie
Electronic Theses and Dissertations
Ghanaian immigrants and second-generation Ghanaian-American Millennials are largely ignored in scholarship. Using qualitative methods, this study explored the experiences of Ghanaian-American Millennials who are first, 1.5, and second-generations with the purpose of understanding how they create, negotiate, and re-create identities. Twenty-one individuals were interviewed using a phenomenological approach. The main findings suggest that even though the sample populations were of different immigrant generations, they have some similar experiences, which demonstrates the value in exploring age instead of solely immigrant generation. The findings also suggest that there are a number of complex layers that are involved in identity development and negotiation …
Laser Spectroscopy Investigations Of Jet-Cooled Metal-Containing Free Radicals., Anam Chandra Paul
Laser Spectroscopy Investigations Of Jet-Cooled Metal-Containing Free Radicals., Anam Chandra Paul
Electronic Theses and Dissertations
Metal-containing free radicals are important intermediates in metal-surface reactions and the interactions between metals and organic molecules. Among metal-containing free radicals, monovalent derivatives of alkaline earth metals have been extensively investigated by using spectroscopic techniques in a gas phase, mainly in Broida ovens or under supersonic-jet-cooled conditions. In the present study, the results of performed spectroscopic investigations of both metal-containing monoalkoxides (CaOR) and metal oxides (MO) radicals have been reported. Laser-induced fluorescence (LIF) and dispersed fluorescence (DF) spectra of the electronic transition of the calcium CaOR radicals have been obtained under jet-cooled conditions. Complete active space self-consistent field (CASSCF) and …
A Recombinant Cholera Toxin B Subunit Variant (Ctb-Kdel) Exhibits Unique Colon Mucosal Healing Effects That Have Therapeutic Implications For Inflammatory Bowel Disease., Joshua Mark Royal
A Recombinant Cholera Toxin B Subunit Variant (Ctb-Kdel) Exhibits Unique Colon Mucosal Healing Effects That Have Therapeutic Implications For Inflammatory Bowel Disease., Joshua Mark Royal
Electronic Theses and Dissertations
This dissertation uncovers the mechanism and explores the utility of a recombinant cholera toxin B subunit (CTB) variant containing a KDEL endoplasmic reticulum (ER) retention motif (CTB-KDEL) as a drug candidate for the treatment of inflammatory bowel disease (IBD). CTB is a mucosal immunomodulatory protein that induces robust mucosal and systemic antibody responses. This well-known biological activity has been exploited in cholera prevention (as a component of Dukoral® vaccine) and vaccine development for decades. On the other hand, several studies have investigated CTB’s immunotherapeutic potential in the treatment of inflammatory diseases such as Crohn’s disease and asthma. Here, we reveal …
The Identification Of Long Non-Coding Rna Zfas1 Through An Exploratory Rna-Sequencing Analysis And Its Association With Epithelial-To-Mesenchymal Transition In Colon Cancer Adenocarcinoma., Stephen J. O'Brien
Electronic Theses and Dissertations
Colorectal adenocarcinoma is the fourth most common cancer diagnosed worldwide and is a significant cause of morbidity and mortality. This dissertation performed an exploratory RNA-sequencing analysis comparing gene expression between colon adenocarcinoma tissue and paired normal colon epithelium. After identification of a number of lncRNAs that were increased in expression in colon adenocarcinoma compared to normal colon epithelium, we aimed to validate the expression and investigate their function in vitro. Specifically, we focused on the lncRNA ZFAS1 and its association with epithelial-to-mesenchymal transition. These studies found the following: 1. Seven candidate lncRNAs were identified from the exploratory RNA-sequencing analysis to …
The Effects Of Nicotine And Cigarette Smoking On Cardiac Electrophysiology., Affan B. Irfan
The Effects Of Nicotine And Cigarette Smoking On Cardiac Electrophysiology., Affan B. Irfan
Electronic Theses and Dissertations
Cigarette smoking is a leading cause of preventable disease and premature death worldwide. The adverse effects of cigarette smoking, including proarrhythmia, are related to the mixture of chemicals, including nicotine (which sustains tobacco addiction). However, it remains unclear which individual tobacco smoke constituents and biological pathways mediate this increased risk. The purpose of this research was to explore the chronic effects of cigarette smoking, as well as compare the acute effects of nicotine and cigarette smoking, and the possible role of β-adrenoreceptors, on human cardiac electrophysiology. Chapter 1 is a comprehensive literature review of (a) the ex vivo and in …
Middle School Outreach Efforts To Involve Immigrant Parents: What Are The Perceptions Of School Personnel And Immigrant Parents?, Marcella Denise Franklin-Williams
Middle School Outreach Efforts To Involve Immigrant Parents: What Are The Perceptions Of School Personnel And Immigrant Parents?, Marcella Denise Franklin-Williams
Electronic Theses and Dissertations
Throughout the years, a concern plaguing the education world is parent involvement. Ongoing research indicates students whose parents and family members are involved tend to experience greater academic achievement and decreased behavior issues (McNeal, 2015). With regard to parent involvement, immigrant parent involvement takes this concern to a new level with regard to the growing racial and ethnic diversity in education (Outley & Skuza, 2019). Guided by Epstein’s six types of involvement and Yosso’s community cultural wealth, this study explores one urban middle school’s outreach efforts to involve immigrant parents. In this qualitative case study, one middle schools’ stakeholders-the principal, …
Exploratory Learning Activities In The Physics Classroom: Contrasting Cases Versus A Rich Dataset., Campbell Rightmyer Bego
Exploratory Learning Activities In The Physics Classroom: Contrasting Cases Versus A Rich Dataset., Campbell Rightmyer Bego
Electronic Theses and Dissertations
In exploratory learning, students engage in an exploration activity on a new topic prior to instruction. This inversion of the traditional tell-then-practice order has been shown to benefit learning outcomes, especially conceptual knowledge and preparation for future learning, but not always. In three studies, the current work examines whether the type of exploration activity impacts learning mechanisms and outcomes, on the topic of gravitational field in undergraduate physics classrooms. Activities using either contrasting cases (CC) or a rich dataset (RD) are compared in two instructional orders, explore-first (EF) and instruct-first (IF). Learning outcomes measured procedural knowledge, conceptual knowledge, and performance …
Laser Spectroscopy Investigations On Molecular And Free Radicals Dynamics., Hamzeh Telfah
Laser Spectroscopy Investigations On Molecular And Free Radicals Dynamics., Hamzeh Telfah
Electronic Theses and Dissertations
Studying molecular dynamics and chemical kinetics is important to understand the chemical behavior of renewable energy sources. Laser spectroscopy techniques are powerful tools for the identification and diagnosis of such processes. In this dissertation, using our laser spectroscopy techniques, biofuels and solar energy were targeted as renewable energy sources study. We have studied the ultrafast exciton dynamics for a series of methylammonium lead bromide (CH3NH3PbBr3) nanostructures, nanocrystals (NCs, 0D), nanowires (NWs, 1D), and nanoplatelets (NPs, 2D) as a promising solar energy materials.1-2 Aided by analysis of UV−visible absorption and photoluminescence spectra, features in the transient absorption (TA) spectra are assigned …
Understanding Object Motion Encoding In The Mammalian Retina., Victor Julian Depiero
Understanding Object Motion Encoding In The Mammalian Retina., Victor Julian Depiero
Electronic Theses and Dissertations
Phototransduction, transmission of visual information down the optic nerve incurs delays on the order of 50 – 100ms. This implies that the neuronal representation of a moving object should lag behind the object’s actual position. However, studies have demonstrated that the visual system compensates for neuronal delays using a predictive mechanism called phase advancing, which shifts the population response toward the leading edge of a moving object’s retinal image. To understand how this compensation is achieved in the retina, I investigated cellular and synaptic mechanisms that drive phase advancing. I used three approaches, each testing phase advancing at a …
Police Stress, Depression, And Substance Use Among Police Officers: A General Strain Perspective., Kyra Nicole Fritz
Police Stress, Depression, And Substance Use Among Police Officers: A General Strain Perspective., Kyra Nicole Fritz
Electronic Theses and Dissertations
This dissertation examines the utility of general strain theory in explaining substance use as a form of coping among a sample of police officers in a Midwestern, metropolitan city. The dissertation is comprised of five chapters, including the introduction, literature review, method, results, and discussion. Chapter one describes the stressful nature of a career in law enforcement, concentrating on the adverse consequences of prolonged stress, including depression and substance use. Chapter one also examines strain, depression, and substance use among police officers using a general strain perspective, highlighting the limitations of existing empirical studies. Chapter two details the theoretical premise …
Simulation And Optimization Of A Multi-Agent System On Physical Internet Enabled Interconnected Urban Logistics., Long Zheng
Electronic Theses and Dissertations
An urban logistics system is composed of multiple agents, e.g., shippers, carriers, and distribution centers, etc., and multi-modal networks. The structure of Physical Internet (PI) transportation network is different from current logistics practices, and simulation can effectively model a series of PI-approach scenarios. In addition to the baseline model, three more scenarios are enacted based on different characteristics: shared trucks, shared hubs, and shared flows with other less-than-truckload shipments passing through the urban area. Five performance measures, i.e., truck distance per container, mean truck time per container, lead time, CO2 emissions, and transport mean fill rate, are included in …